Influence of Glucose on Corrosion Fatigue and Cytocompatibility of Mg–Zn–Zr–Y Alloy

Abstract

This article mainly focuses on the effects of glucose on the mechanical safety and cytotoxicity of Mg alloys used as implant materials. Under the corrosive human body fluid and dynamic loading, especially in a high-glucose environment, Mg alloys are inevitably subjected to the decrease of mechanical properties in the process of long-time service and eventually faced with corrosion fatigue (CF) failure. Herein, a comparative study on the dynamic mechanical properties of the Mg-Zn-Zr-Y alloy is evaluated by carrying out fatigue tests in air and in Hank's solution. CF and cytocompatibility of Mg-Zn-Zr-Y alloys response to different glucose contents (1 and 3 g L À1 ) are also detected. The Mg-Zn-Zr-Y alloy exhibits an excellent fatigue limit of 119.43 MPa in air compared with 47.77 MPa in Hank's solution at 37 C. The fatigue cracks initiate at the microstructural defects in air and nucleate at corrosion pits in Hank's solution. Better corrosion resistance and enhanced CF are obtained with the increasing glucose content in Hank's solution. The in vitro tests with MC3T3-E1 cells demonstrate that the Mg-Zn-Zr-Y alloy shows excellent cytocompatibility under high-glucose condition.

Corrosion behaviour of AZ31 magnesium alloy in saline containing glucose at different concentrations

“…The increase in the anodic current density with increasing polarization potential can be explained by the oxidation of glucose to gluconic acid, which disrupts the Mg(OH)2 layer on the surface of AZ31 alloy together with chlorides. This explanation is consistent with the literature [5,6,[8][9][10]. The decrease in the corrosion rate for higher glucose concentrations (1-5 g/L) can be related to the increase in the viscosity of the solution and consequently the limitation of the mobility of ions and molecules at the surface of the magnesium material.…”

Challenges in synthesis of heterostructures

“…The ability to prepare 2D layers not found in equilibrium phase diagrams, however, make MBE potentially a key growth technique to supply micromechanical assembly platforms with 2D layers that cannot be obtained via other approaches. [120][121][122][123][124]…”

The influence of alternating cyclic dynamic loads with different low frequencies on the bio-corrosion behaviors of AZ31B magnesium alloy in vitro

“…However, in the real physiological environment of the human body, different degrees and forms of dynamic loads would applied to implanted medical devices in vivo due to the daily activities of the patients [ [19] , [20] , [21] ]. Recently, many scholars have studied the degradation behavior of magnesium alloys under dynamic loading environments through corrosion fatigue experiments [ 22 , 23 ]. Liu et al [ 24 ] studied the corrosion fatigue of Mg-Zn-Y-Nd alloy in SBF solution and found that the fatigue corrosion behavior of magnesium alloy in SBF solution was different from that in air, which shows that the degradation behavior of magnesium alloy in the simulated physiological environment is closely related to the fatigue performance of the alloy and the external corrosive environment.…”