Influence of glucocorticoids on some morphological and biochemical aspects of rat small intestinal mucosa

Lafont, J.; Pillon, R.

doi:10.1016/0304-4165(75)90010-0

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…In the intestine cortisol may be one of the natural triggers for the accumulation of uridine kinase, since both the high concentrations ofcortisone during late gestation and the resumption of the functioning of the pituitary-adrenal axis in the late suckling period (Levine & Mullins, 1966) were accompanied by high enzyme activities; high activities were evoked by a single injection of cortisol during the ebb period of the pituitary-adrenal interaction. The response of intestinal uridine kinase to a single injection of cortisol was more rapid than that usually seen for other cortisol-induced intestinal enzymes (Koldovsky & Palmieri, 1971;Koldovsky & Herbst, 1973;Moog et al, 1971Moog et al, , 1973Lafont & Pilon, 1975;Yeh & Moog, 1975). Severalfold increases in intestinal uridine kinase followed 18h of starvation; this trigger for increased enzyme accumulation extended to ages when cortisol was no longer a productive stimulus for raising the enzyme activity.…”

Section: Discussionmentioning

confidence: 85%

Uridine kinase activities in developing, adult and neoplastic rat tissues

Herzfeld¹,

Raper²

1979

Biochemical Journal

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Uridine kinase activities were found chiefly in the soluble fractions of rat tissues. In normal adults the activities ranged from 13 munits/g in skeletal muscle to 178 munits/g in colon. Enzyme activities in several rat neoplasms were significantly higher (e.g. in a fibrosarcoma, mammary carcinoma, renal carcinoma, pancreatic carcinoma and lymphocytic lymphoma, but not in a fast-growing Morris hepatoma). The activities were not related to tumour growth rates or sizes. In normal foetal liver, lung, brain, heart and kidney, uridine kinase concentrations equalled or exceeded those in the adult homologous tissue, but maximal activities in liver were reached 3--5 days post partum. In suckling rats the intestinal activity decreased substantially immediately after birth and normally did not rise again until late in the third postnatal week. Premature upsurges could be evoked by an injection of cortisol or by starvation of the pups overnight. Pancreatic activity was absent from 1-day-old rats, and only about 5% of the adult activity was reached by day 20; adult activities were attained rapidly after weaning. In pancreas, precocious formation or uridine kinase was elicited by overnight starvation of 2-week-old rats.

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Section: Discussionmentioning

confidence: 85%

Uridine kinase activities in developing, adult and neoplastic rat tissues

Herzfeld¹,

Raper²

1979

Biochemical Journal

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“…The eects of corticosteroid include the alteration of the metabolism of carbohydrate, lipid and mineral in various tissues and the anti-in¯ammatory action (Johnson 1986;Oda and Takahisa 1996). Lafont and Pilon (1975) reported that intraperitoneal and subcutaneous injection of high doses of cortisol (5 mg/100 g body weight) to adult rats elicited a reduction both in total protein content of the small intestinal mucosa and in the maltase and alkaline phosphatase of the small intestine. Administration of corticoid inhibits the active transport of calcium in the small intestine of rat (Kimgerg et al 1971).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, low doses of the drug cause alterations in the morphology of the small intestine, including a reduction of villous height and crypt depth, and a decrease in cell production rates and the crypt population (Wall and Peters 1971;Wright et al 1978). These eects of corticoids are known to be dose-dependent (Lafont and Pilon 1975), and the dose-dependent changes in the small intestine may in¯uence the attachment and development of the worm.…”

Section: Resultsmentioning

confidence: 99%

“…The increase of body weight and obesity have been known as side eects in humans treated with clinical doses of corticosteroid (Dollery 1993). Lafont and Pilon (1975) reported that rats injected with 0.5 mg hydrocortisone/100 g body weight grew normally, whereas the growth of the rats injected with strong doses (5 mg/ 100 g) stopped. The clinical dose of PTBA for human is 4±20 mg/day and the present study a used much higher dose, 0.5±10 mg/head of Mongolian gerbil.…”

Section: Resultsmentioning

confidence: 99%

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Dose dependency of prednisolone tertiary-butylacetate (PTBA) treatment on the establishment and site predilection of Echinococcus multilocularis in an alternative definitive host model using Mongolian gerbil ( Meriones unguiculatus )

Matsuo

Nonaka

Oku

et al. 2000

Parasitology Research

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Mongolian gerbils (Meriones unguiculatus) were orally inoculated with 10,000 protoscoleces of Echinococcus multilocularis per head after being divided into five groups (A E). Each group was dosed with prednisolone tertiary-butylacetate (PTBA) as follows: A, 0 mg; B, 0.5 mg; C, 2 mg; D, 5 mg; and E, 10 mg/head. All animals were injected subcutaneously with control solvent or PTBA every other day from 6 days pre- to 6 days post-infection. Autopsy was performed at 7 days post-infection. Doses of PTBA and the number of worms recovered showed a positive correlation (r = 0.929, P < 0.0001). In groups A, B and C, the predilection site of the worms in the small intestine could not be determined, while in group D the worms were found more in the anterior part. In group E, the predilection site was the anterior part, followed by the middle and the posterior parts of the small intestine (Fisher's test: P < 0.01). The number of worms recovered from the anterior and the middle part of the small intestine also correlated positively with PTBA dose (anterior part: r = 0.930, P < 0.0001, middle part: r = 0.917, P < 0.0001). All groups of the PTBA-treated animals showed significant loss of weight compared to the nontreated animals (P < 0.01).

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Intestinal adaptation in short-bowel syndrome

Lentze

1989

Eur J Pediatr

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After massive resection of the small intestine the remnant mucosa has an important capacity to enlarge the absorptive surface for the digestion, hydrolysis and absorption of nutrients. This intestinal adaptation is achieved by the interaction of various factors. Oral nutrients together with pancreatic biliary secretions stimulate the mucosa to become hyperplastic. Secondary to these luminal factors hormones play an important role in the adaptive process. Among the hormones, enteroglucagon is the most important growth promoting agent together with other growth factors such as epidermal growth factor, prostaglandin E2 and human growth hormone analogues, e.g. plerocercoid growth factor from the plerocercoid larvae of the tapeworm Spirometra mansonoides. The intestinal enterocyte is the target of these factors and within the cell the synthesis of polyamines, which are responsible for rapid growth, is the most essential step for the development of hyperplasia after resection. The rate limiting enzyme for polyamine synthesis ornithine decarboxylase (ODC) reacts to trophic stimuli with an increased activity. Thereafter rapid accumulation of tissue polyamines occurs. Blockade of ODC by specific inhibitors is accompanied by absence of intestinal hyperplasia after resection. Therefore it is concluded that ODC plays a key role in the intestinal adaptation of the remnant small bowel. To start and enhance intestinal hyperplasia after resection in patients with short bowel syndrome introduction of oral nutrition as soon as possible after operation is very important. On account of gastric acid hypersecretion the use of H2 receptor blocking agents is recommended. A decreased intestinal transit time is treated with loperamide.(ABSTRACT TRUNCATED AT 250 WORDS)

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Influence of glucocorticoids on some morphological and biochemical aspects of rat small intestinal mucosa

Cited by 11 publications

References 19 publications

Uridine kinase activities in developing, adult and neoplastic rat tissues

Uridine kinase activities in developing, adult and neoplastic rat tissues

Dose dependency of prednisolone tertiary-butylacetate (PTBA) treatment on the establishment and site predilection of Echinococcus multilocularis in an alternative definitive host model using Mongolian gerbil ( Meriones unguiculatus )

Intestinal adaptation in short-bowel syndrome

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