Influence of glucocorticoid hormones on the thyroid gland function

Abstract

The injection of exogenous analogues of glucocorticoid hormones (cortisone, hydrocortisone, corticosterone, dexamethasone, betamethasone, etc.) leads to a change in thyroid function at all levels (biosynthesis and secretion of hormones by the thyroid gland, the transport, interaction with receptors in target organs, biological action, their metabolism and excretion). Glucocorticoid hormones change regulationof the thyroid function: transhypophysially (glucocorticoids block the secretion of thyroliberin, thyroid stimulating hormone, corticotropin releasing hormone, somatoliberin and the production of somatotropin under the influence of the last one) and parahypophysially (glucocorticoids stimulate formation of insulin in β-cells of the pancreas).