Influence of glottal closure on the phonatory process in <i>ex vivo</i> porcine larynges

Birk, Veronika; Kniesburges, Stefan; Semmler, Marion; Berry, David A.; Bohr, Christopher; Döllinger, Michael; Schützenberger, Anne

doi:10.1121/1.5007952

Cited by 23 publications

(25 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to the data of Döllinger et al [39] the value of R B for GGI 3 in this study was 42% higher; see Table 7. For GGI 1-2 our findings support other studies that higher energy transfer R B from the glottal flow to vocal folds yields an improved acoustic quality (i.e., higher CPP values) [39,60,65]. Surprisingly, we found contrary results for GGI 2-3 , that R B was increasing/improving while CPP decreased/deteriorated even further; see Table 5.…”

Section: Aerodynamic Parameterssupporting

confidence: 85%

“…Also, similar findings were reported by Wolfe et al [59] who found a correlation between jitter and the degree of dysphonia by considering the mean fundamental frequency. Hence, an increased fundamental frequency may be seen as an indicator of a pathological or disordered voice [60]. Air flow strength here (120 mL/s) is close to the value of Döllinger et al [39] of 117 mL/s, which was to be expected since the data were collected during the same series of experiments.…”

Section: Fundamental Phonatory Parameterssupporting

confidence: 83%

See 1 more Smart Citation

Impact of Subharmonic and Aperiodic Laryngeal Dynamics on the Phonatory Process Analyzed in Ex Vivo Rabbit Models

et al. 2019

Self Cite

View full text Add to dashboard Cite

Normal voice is characterized by periodic oscillations of the vocal folds. On the other hand, disordered voice dynamics (e.g., subharmonic and aperiodic oscillations) are often associated with voice pathologies and dysphonia. Unfortunately, not all investigations may be conducted on human subjects; hence animal laryngeal studies have been performed for many years to better understand human phonation. The rabbit larynx has been shown to be a potential model of the human larynx. Despite this fact, only a few studies regarding the phonatory parameters of rabbit larynges have been performed. Further, to the best of our knowledge, no ex vivo study has systematically investigated phonatory parameters from high-speed, audio and subglottal pressure data with irregular oscillations. To remedy this, the present study analyzes experiments with sustained phonation in 11 ex vivo rabbit larynges for 51 conditions of disordered vocal fold dynamics. (1) The results of this study support previous findings on non-disordered data, that the stronger the glottal closure insufficiency is during phonation, the worse the phonatory characteristics are; (2) aperiodic oscillations showed worse phonatory results than subharmonic oscillations; (3) in the presence of both types of irregular vibrations, the voice quality (i.e., cepstral peak prominence) of the audio and subglottal signal greatly deteriorated compared to normal/periodic vibrations. In summary, our results suggest that the presence of both types of irregular vibration have a major impact on voice quality and should be considered along with glottal closure measures in medical diagnosis and treatment.

show abstract

Section: Aerodynamic Parameterssupporting

confidence: 85%

Section: Fundamental Phonatory Parameterssupporting

confidence: 83%

Impact of Subharmonic and Aperiodic Laryngeal Dynamics on the Phonatory Process Analyzed in Ex Vivo Rabbit Models

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…(3) Two rods were symmetrically tightened posteriorly, simulating the adduction process, to bring the larynx in phonatory position, i.e., until the glottis was entirely closed. Then the phonatory threshold pressure (PTP) level was determined by manually and continuously increasing the air flow through the larynx until sustained phonation occurred (Birk et al, 2017b), i.e., PTP was determined as the subglottal pressure level at which the vocal folds initiated sustained vibration. From the PTP, the airflow was increased 14 times successively in steps of 0.5 lm À1 (8.33 mls À1 ).…”

Section: Experimental Procedures For Phonationmentioning

confidence: 99%

Investigation of phonatory characteristics using ex vivo rabbit larynges

Döllinger

Kniesburges

Berry

et al. 2018

The Journal of the Acoustical Society of America

Self Cite

View full text Add to dashboard Cite

Quantitative analysis of phonatory characteristics of rabbits has been widely neglected. However, preliminary studies established the rabbit larynx as a potential model of human phonation. This study reports quantitative data on phonation using ex vivo rabbit larynx models to achieve more insight into dependencies of three main components of the phonation process, including airflow, vocal fold dynamics, and the acoustic output. Sustained phonation was induced in 11 ex vivo rabbit larynges. For 414 phonatory conditions, vocal fold vibrations, acoustic, and aerodynamic parameters were analyzed as functions of longitudinal vocal fold pre-stress, applied air flow, and glottal closure insufficiency. Dimensions of the vocal folds were measured and histological data were analyzed. Glottal closure characteristics improved for increasing longitudinal pre-stress and applied airflow. For the subglottal pressure signal only the cepstral peak prominence showed dependency on glottal closure. In contrast, vibrational, acoustic, and aerodynamic parameters were found to be highly dependent on the degree of glottal closure: The more complete the glottal closure during phonation, the better the aerodynamic and acoustic characteristics. Hence, complete or at least partial glottal closure appears to enhance acoustic signal quality. Finally, results validate the ex vivo rabbit larynx as an effective model for analyzing the phonatory process.

show abstract

“…In the 2D view from above, the vocal folds move medially toward each other, giving the impression of a complete closure of the glottis . Because they are on a different level, they allow too much air to pass through the glottis, causing alterations of the normal vocal fold vibration cycle and dysphonia . In this case, the evaluation of the closing and closure process, as well as the determination of symmetry between the left and right vocal fold, would be important.…”

Section: Discussionmentioning

confidence: 99%

“…38 Because they are on a different level, they allow too much air to pass through the glottis, causing alterations of the normal vocal fold vibration cycle and dysphonia. 39,40 In this case, the evaluation of the closing and closure process, as well as the determination of symmetry between the left and right vocal fold, would be important. As assumed, the newly invented 3D imaging system can visualize such information.…”

Section: Discussionmentioning

confidence: 99%

Development of three‐dimensional laryngostroboscopy for office‐based laryngeal diagnostics and phonosurgical therapy

et al. 2018

View full text Add to dashboard Cite

Objective To develop a three‐dimensional (3D) laryngostroboscopic examination unit, compare the optic playback quality in relation to established 2D procedures, and report the first case series using 3D rigid laryngostroboscopy for diagnosis and management of laryngotracheal diseases. Study Design Laboratory study, prospective case series. Methods The optical efficacy of newly developed rigid 3D endoscopes was examined in a laboratory setting. Diagnostic suitability was investigated in 100 subjects (50 male, 50 female) receiving 2D high‐definition (HD) and 3D laryngostroboscopy. Two of the subjects subsequently underwent 3D‐assisted office‐based transoral phonosurgery under local anesthesia. Main outcome measures were comparative visualization of laryngotracheal pathologies, influence on preoperative planning, and evaluation of prognostic factors for the outcome of phonosurgical interventions. Results Three‐dimensional endostroboscopic procedures were effectively optimized to establish an examination protocol for all‐day clinical use. Office‐based 3D laryngostroboscopy was successfully applied in subjects with normal anatomy (n = 10) and various laryngotracheal findings (n = 90). In comparison to 2D HD videolaryngostroboscopy, the 3D view offered enhanced visualization of laryngotracheal anatomy, with qualitatively improved depth perception and spatial representation. In organic pathologies, this resulted in a more precise indication of phonosurgical procedures, increased accuracy in surgical planning, facilitated office‐based endoscopic surgery, and better evaluation of prognostic factors for the outcome of phonosurgical interventions. Conclusion Three‐dimensional laryngostroboscopy proved to increase the understanding of functional and surgical anatomy. Its application has enormous potential for improving the diagnostic value of laryngoscopy, surgical precision in laryngotracheal interventions, tissue preservation, and methods of teaching. Level of Evidence NA Laryngoscope, 128:2823–2831, 2018

show abstract

Influence of glottal closure on the phonatory process in ex vivo porcine larynges

Cited by 23 publications

References 54 publications

Impact of Subharmonic and Aperiodic Laryngeal Dynamics on the Phonatory Process Analyzed in Ex Vivo Rabbit Models

Impact of Subharmonic and Aperiodic Laryngeal Dynamics on the Phonatory Process Analyzed in Ex Vivo Rabbit Models

Investigation of phonatory characteristics using ex vivo rabbit larynges

Development of three‐dimensional laryngostroboscopy for office‐based laryngeal diagnostics and phonosurgical therapy

Contact Info

Product

Resources

About