Influence of gestational age and birth weight in neonatal cholesterol response to total parenteral nutrition

Nghiem-Rao, T. Hang; Dahlgren, Allison F.; Kalluri, Deepti; Cao, Yumei; Simpson, Pippa; Patel, Shailendra B.

doi:10.1016/j.jacl.2016.03.005

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Administration of PN is associated with increases in plasma cholesterol and triglyceride levels [ 67 ]. In the short-term, this transient increase in serum lipid parameters is of less concern than for patients receiving long-term PN.…”

Section: Metabolic Effectsmentioning

confidence: 99%

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Cai¹,

Calder

Cury-Boaventura

et al. 2018

Nutrients

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Intravenous lipid emulsions (ILEs) have been an integral component of parenteral nutrition for more than 50 years. Numerous formulations are available and are based on vegetable (soybean, olive, coconut) and animal (fish) oils. Therefore, each of these formulations has a unique fatty acid composition that offers both benefits and limitations. As clinical experience and our understanding of the effects of fatty acids on various physiological processes has grown, there is evidence to suggest that some ILEs may have benefits compared with others. Current evidence suggests that olive oil-based ILE may preserve immune, hepatobiliary, and endothelial cell function, and may reduce lipid peroxidation and plasma lipid levels. There is good evidence from a large randomized controlled study to support a benefit of olive oil-based ILE over soybean oil-based ILE on reducing infections in critically ill patients. At present there is limited evidence to demonstrate a benefit of olive oil-based ILE over other ILEs on glucose metabolism, and few data exist to demonstrate a benefit on clinical outcomes such as hospital or intensive care unit stay, duration of mechanical ventilation, or mortality. We review the current research and clinical evidence supporting the potential positive biological and clinical aspects of olive oil-based ILE and conclude that olive oil-based ILE is well tolerated and provides effective nutritional support to various PN-requiring patient populations. Olive oil-based ILE appears to support the innate immune system, is associated with fewer infections, induces less lipid peroxidation, and is not associated with increased hepatobiliary or lipid disturbances. These data would suggest that olive oil-based ILE is a valuable option in various PN-requiring patient populations.

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Section: Metabolic Effectsmentioning

confidence: 99%

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Cai¹,

Calder

Cury-Boaventura

et al. 2018

Nutrients

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“…During a short period of TPN with soy lipid, we found greater cumulative exposure to plant sterols in very preterm infants compared to more mature infants 17 . Furthermore, cholesterol response to soy lipid is inversely related to gestational age and birth weight 28 . Therefore, differences in the expression of critical sterol-regulating genes between early life and adulthood may be of particular significance Despite recapitulating many human hepatocyte functions, iHLC have been reported to have a more immature phenotype resembling the fetal or neonatal liver 19,33 and suggest that iHLC may be relevant for modeling the immature liver.…”

Section: Discussionmentioning

confidence: 99%

Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells Provide Insights on Parenteral Nutrition Associated Cholestasis in the Immature Liver

Nghiem-Rao

Pfeifer

Asuncion

et al. 2021

Preprint

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Parenteral nutrition-associated cholestasis (PNAC) significantly limits the safety of intravenous parenteral nutrition (PN). Critically ill infants are highly vulnerable to PNAC-related morbidity and mortality, however the impact of hepatic immaturity on PNAC is poorly understood. We examined developmental differences between fetal/infant and adult livers, and used human induced pluripotent stem cell-derived hepatocyte-like cells (iHLC) to gain insights into the contribution of development to altered sterol metabolism and PNAC. We used RNA-sequencing and computational techniques to compare gene expression patterns in human fetal/infant livers, adult liver, and iHLC. We identified distinct gene expression profiles between the human feta/infant livers compared to adult liver, and close resemblance of iHLC to human developing livers. Compared to adult, both developing livers and iHLC had significant downregulation of xenobiotic, bile acid, and fatty acid metabolism; and lower expression of the sterol metabolizing gene ABCG8. When challenged with stigmasterol, a plant sterol found in intravenous soy lipids, lipid accumulation was significantly higher in iHLC compared to adult-derived HepG2 cells. Our findings provide insights into altered bile acid and lipid metabolizing processes in the immature human liver, and support the use of iHLC as a relevant model system of developing liver to study lipid metabolism and PNAC.

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“…weight as associated with higher concentrations of total cholesterol (L. H. Chen et al, 2017;Nghiem-Rao et al, 2016). The intervention group had better cholesterol control, which may have contributed to this group having a more normal neonatal birth weight.…”

Section: Effects Of the Intervention On The Participants And Their Ne...mentioning

confidence: 99%

Effectiveness of a Nurse-Led Web-Based Health Management in Preventing Women With Gestational Diabetes From Developing Metabolic Syndrome

Chao²,

Chang³

et al. 2021

Journal of Nursing Research

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Background Women with gestational diabetes mellitus (GDM) are more likely to develop metabolic syndrome (MS). However, the effectiveness of web-based health management in preventing women at high risk of GDM from developing MS has rarely been studied. Purpose The aim of this study was to evaluate the longitudinal effects of nurse-led web-based health management on maternal anthropometric, metabolic measures, and neonatal outcomes. Methods A randomized controlled trial was conducted from February 2017 to February 2018, in accordance with the Consolidated Standards of Reporting Trials guidelines. Data were collected from 112 pregnant women at high risk of GDM who had been screened from 984 potential participants in northern Taiwan. Participants were randomly assigned to the intervention group (n = 56) or the control group (n = 56). The intervention group received a 6-month nurse-led, web-based health management program as well as consultations conducted via the LINE mobile app. Anthropometric and metabolic measures were assessed at baseline (Time 0, prior to 28 weeks of gestation), Time 1 (36–40 weeks of gestation), and Time 2 (6–12 weeks of postpartum). Maternal and neonatal outcomes were assessed at delivery. Clinical trial was registered. Results Analysis using the general estimating equation models found that anthropometric and metabolic measures were significantly better in the intervention group than the control group and varied with time. At Time 1, the levels of diastolic pressure (β = −4.981, p = .025) and triglyceride (TG; β = −33.69, p = .020) were significantly lower in the intervention group than the control group, and at Time 2, the incidence of MS in the intervention group was lower than that in the control group (χ2 = 6.022, p = .014). The number of newborns with low birth weight in the intervention group was lower than that in the control group (χ2 = 6.729, p = .012). Conclusion/Implications for Practice This nurse-led, web-based health management was shown to be effective in improving MS outcomes and may play an important role and show feasible clinical value in changing the current pregnancy care model.

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Influence of gestational age and birth weight in neonatal cholesterol response to total parenteral nutrition

Cited by 4 publications

References 38 publications

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells Provide Insights on Parenteral Nutrition Associated Cholestasis in the Immature Liver

Effectiveness of a Nurse-Led Web-Based Health Management in Preventing Women With Gestational Diabetes From Developing Metabolic Syndrome

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