Influence of Gestation and Lactation on Radiostrontium-Induced Malignancies in Mice: II. Retention of Radiostrontium and Relation Between Tumour Incidence and Excretion Rate

Nilsson, A.; Nelson, Arne; Rönnbäck, C.; Sjödén, Ann-Marie; Walinder, G.; Hertzberg, O.

doi:10.3109/02841856709138572

Cited by 9 publications

(2 citation statements)

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“…An estimation of the radiation burden, based on calculated mean accumulated dose to the mouse skeleton given by Nilsson et al (1967) yielded in our experiment with 5 ~Ci 9°Sr-9°Y about 65 rd (0.65 Gy) after 2 days and about 1,000 rd (10 Gy) after 64 days. An estimation of the radiation burden, based on calculated mean accumulated dose to the mouse skeleton given by Nilsson et al (1967) yielded in our experiment with 5 ~Ci 9°Sr-9°Y about 65 rd (0.65 Gy) after 2 days and about 1,000 rd (10 Gy) after 64 days.…”

Section: Utility Of Peripheral Blood Fe-kineticsmentioning

confidence: 76%

“…The time-interval between the application of radiostrontium and radioiron injection essentially reflected the varying radiation burden in the bone marrow, which, however, was not linear with time (Nilsson et al, 1967;Steinbach and Weber, 1970;Stevenson, 1975). 1 (see Experimental Design) on the incorporation of radioiron into red blood cells (RBCs) of peripheral blood as a function of time after the injection of 59Fe and of 9°Sr-9°Y.…”

Section: Iron-59-incorporationmentioning

confidence: 99%

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Haematological studies on90Sr-90Y-toxicity

Mönig

Stevenson

Seiter

et al. 1980

Radiat Environ Biophys

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Erythropoietic changes were observed, measured by 59Fe-uptake into red blood cells, and on radioiron turnover from blood plasma, at different time intervals (2--64 days) after treating adult female mice with varying activities of 90Sr-90Y. Activities of 2.5 or 5.0 mu Ci radiostrontium per animal lead to a depression at time intervals of two and four days, at longer periods there was an overshoot. With activities of 0.5 or 1.0 mu Ci radiostrontium disturbances in the radioiron uptake are still observed, although these effects are not as pronounced as in experiments with higher burdens. In comparison with results obtained in experiments in which the plasma 59Fe-turnover was applied, even with an activity of 5 mu Ci radiostrontium per mouse, no deviation as against the untreated controls was detected.

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Section: Utility Of Peripheral Blood Fe-kineticsmentioning

confidence: 76%

Section: Iron-59-incorporationmentioning

confidence: 99%