Influence of genetic dissimilarity in the reproductive success and mate choice of brown trout – females fishing for optimal MHC dissimilarity

Forsberg, Lars A.; Dannewitz, Johan; Petersson, Erik; Grahn, Mats

doi:10.1111/j.1420-9101.2007.01380.x

Cited by 112 publications

(160 citation statements)

References 67 publications

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“…However, one inevitable shortcoming of natural studies is that mating preferences and indirect genetic benefits must necessarily be inferred from posterior analysis of offspring genotypes (e.g. Forsberg et al 2007). Here, we inferred MHC-mediated mate choice from the analysis of F1 genotypes among returning adults, which could have also reflected MHC-related mortality at any stage of development.…”

Section: Discussionmentioning

confidence: 99%

MHC-mediated mate choice increases parasite resistance in salmon

2008

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Natural (parasite-driven) and sexual selection are thought to maintain high polymorphism in the genes of the major histocompatibility complex (MHC), but support for a link between mate choice, MHC variation and increased parasite resistance is circumstantial. We compared MHC diversity and Anisakis loads among anadromous Atlantic salmon (Salmo salar L.) returning to four rivers to spawn, which had originated from natural spawning (parents allowed to mate freely) or artificial crosses (parents deprived from the potential benefits of mate choice). We found that the offspring of artificially bred salmon had higher parasite loads and were almost four times more likely to be infected than free-mating salmon, despite having similar levels of MHC diversity. Moreover, the offspring of wild salmon were more MHC dissimilar than the offspring of artificially crossed salmon, and uninfected fish were more dissimilar for MHC than infected fish. Thus, our results suggest a link between disassortative mating and offspring benefits and indicate that MHC-mediated mate choice and natural (parasite-driven) selection act in combination to maintain MHC diversity, and hence fitness. Therefore, artificial breeding programmes that negate the potential genetic benefits of mate choice may result in inherently inferior offspring, regardless of population size, rearing conditions or genetic diversity.

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Section: Discussionmentioning

confidence: 99%

MHC-mediated mate choice increases parasite resistance in salmon

2008

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“…The predictions of model (R+M+G 1 +G 1 2 ) are consistent with the hypothesis that mate choice acts either to avoid the costs of both inbreeding and outbreeding at a genome-wide level, or to pass on a combination of MHC genes to offspring that represents an optimal trade-off between the ability to recognise a breadth of antigens via increased MHC-diversity and disadvantages associated with high MHC-diversity (Nowak et al 1992;Milinski et al 2005;Woelfing et al 2009). Choice for intermediate dissimilarity has also been reported for some female fish (Reusch et al 2001;Milinski et al 2005;Forsberg et al 2007), and birds Baratti et al 2012). The predictions according to the alternative parsimonious model (R+M+G 1 ) are similar to those of our earlier study comparing sires with all potential sires, in which we found selection for maximally, rather than optimally, MHC-dissimilar mates ).…”

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confidence: 98%

Mate-guarding by male mandrills (Mandrillus sphinx) is associated with female MHC genotype

Setchell

Richards

Abbott

et al. 2016

BEHECO

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This is a pre-copyedited, author-produced PDF of an article accepted for publication in Behavioral Ecology following peer review. The version of record Setchell, J. M., Richards, S., Abbott, K. M. Knapp, L. A. (2016) Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. LAY SUMMARYWe examined whether male mate-guarding in mandrills varies with female genotype. Males were less likely to mate-guard females with specific genotypes which may be disadvantageous to offspring, and more likely to mate-guard females with genes that were different to their own, which would result in genetically diverse offspring. ABSTRACTFemale choice for male major histocompatibility complex (MHC) genotype has been widely tested, but the relationship between male mating strategies and female MHC genotype has received far less attention. Moreover, few studies of MHC-associated mate choice test for the fitness effects underlying such choice. We examined mate-guarding by male mandrills, a species with intense male-male competition and female offspring care. We developed a statistical model based on 10 years of observations to describe how the probability a female is mate-guarded varies across her sexual cycle, among cycles and among females. We accounted for female rank, parity and maternal relatedness. We then tested whether the occurrence of mate-guarding is influenced by (i) MHC-dissimilarity, (ii) female MHCdiversity, and (iii) specific female MHC genotypes. Finally, we tested for associations between MHC variables and the ratio of neutrophils to lymphocytes in blood samples taken during routine captures. The best-fit models included either MHC-dissimilarity (males were more likely to mate-guard more dissimilar females, and there was some evidence of preference for intermediate MHC-dissimilarity), or a specific MHC supertype. Four of 11 supertypes investigated were influential and one had a strong negative influence on mateguarding. We found some evidence that the MHC genotype that attracted the least mateguarding was disadvantageous in terms of immune function. However, we did not find evidence that MHC-diversity was related to immune function. These results suggest that highly competitive males modify their mating behaviour based on female MHC genotype, and a possible fitness benefit to mate choice for specific genotypes.

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“…To analyse the magnitude of differences between alleles, we summed the number of amino acid differences from pairwise combinations of alleles in mated birds [25,40]. The average of this score for the 46 known pairs was then compared with the distribution of scores generated from 10 000 simulations of 46 random pairings selected from the same 92 individuals, just as with the allele-sharing analysis [25,40].…”

Section: (D) Microsatellitesmentioning

confidence: 99%

Sequence-based evidence for major histocompatibility complex-disassortative mating in a colonial seabird

Juola

Dearborn

2011

Proc. R. Soc. B.

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The major histocompatibility complex (MHC) is a polymorphic gene family associated with immune defence, and it can play a role in mate choice. Under the genetic compatibility hypothesis, females choose mates that differ genetically from their own MHC genotypes, avoiding inbreeding and/or enhancing the immunocompetence of their offspring. We tested this hypothesis of disassortative mating based on MHC genotypes in a population of great frigatebirds (Fregata minor) by sequencing the second exon of MHC class II B. Extensive haploid cloning yielded two to four alleles per individual, suggesting the amplification of two genes. MHC similarity between mates was not significantly different between pairs that did (n ¼ 4) or did not (n ¼ 42) exhibit extra-pair paternity. Comparing all 46 mated pairs to a distribution based on randomized re-pairings, we observed the following (i): no evidence for mate choice based on maximal or intermediate levels of MHC allele sharing (ii), significantly disassortative mating based on similarity of MHC amino acid sequences, and (iii) no evidence for mate choice based on microsatellite alleles, as measured by either allele sharing or similarity in allele size. This suggests that females choose mates that differ genetically from themselves at MHC loci, but not as an inbreeding-avoidance mechanism.

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Influence of genetic dissimilarity in the reproductive success and mate choice of brown trout – females fishing for optimal MHC dissimilarity

Cited by 112 publications

References 67 publications

MHC-mediated mate choice increases parasite resistance in salmon

MHC-mediated mate choice increases parasite resistance in salmon

Mate-guarding by male mandrills (Mandrillus sphinx) is associated with female MHC genotype

Sequence-based evidence for major histocompatibility complex-disassortative mating in a colonial seabird

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