Influence of Gender on the Onset and Duration of Rocuronium-Induced Neuromuscular Block

Adamus, Milan; Koutná, Jiřina; Gabrhelík, Tomáš; Hubackova, Mariana; Janaskova, Eva

doi:10.5507/bp.2007.051

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…The shorter time to reach maximum muscle relaxation (TOF 0 ) for women, and the longer time to reach TOF 25 indicating the beginning of the reduction of the neuromuscular block effect and to reach TOF 90 indicating the return of muscle power supports this idea [15,17].…”

Section: Discussionsupporting

confidence: 48%

“…In a study of 848 patients using total intravenous anesthesia (TIVA), Adamus et al [17] compared the TOF 0 , TOF 25 and TOF duration after induction with 0.6 mg kg-1 rocuronium. At the end of the study it was observed that the time to reach TOF 0 (91.7±14.3 s compared to 108.0±14.6 s) was shorter for women than for men, while the times to reach TOF 25 (43.3±7.8 min compared to 31.3±5.5 min) and TOF (15.2±5.1min compared to 14.7±4.0 min) were longer.…”

Section: Discussionmentioning

confidence: 99%

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The effect of gender on reversal of non-depolarizing block with Sugammadex

Öztürk¹,

Pişkin²,

Küçükosman³

et al. 2017

Med-Science

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Sugammadex is a rapid and selective aminosteroid agent that has entered use recently. We aimed to research the effect of gender on reversal of non-depolarizing block with sugammadex. We designed a prospective study. The research included a total of 100 cases who underwent rhinoplasty operation administered general anaesthesia. Cases were divided according to gender as male (Group M) and female (Group F). At the end of the operation for patients with TOF value 25%, patients were given 2 mg kg-1 iv sugammadex. Duration from the rocuronium administration until the TOF value was zero(TOF0), the time from sugammadex administration until TOF reached from 25% to 90% was recorded (TOF25-90). The time from TOF90 to extubation was named the extubation duration. From the time the patients entered the PCU until Aldrete score was ≥9 was named the recovery duration and recorded. The time for the groups to TOF25-90 was 123.84 ± 38.03 s in Group M and 122.06 ± 30.461 s in Group F (p > 0.05). The extubation duration was 189.68 ± 41.37 s in Group M and 206.50 ± 45.99 in Group F (p = 0.316). The recovery time was 8.26 ± 14 min in Group M and 8.48 ± 14.23 min in Group F (p = 0.328). After the administration of sugammadex, there was no difference observed between the groups in terms of the TOF25-90 duration, recovery and extubation duration. As a result, conclusion was reached that gender did not affect rocuronium reversal with sugammadex.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

The effect of gender on reversal of non-depolarizing block with Sugammadex

Öztürk¹,

Pişkin²,

Küçükosman³

et al. 2017

Med-Science

View full text Add to dashboard Cite

show abstract

“…We designed a study to compare the i-gel TM with the AuraOnce TM under conditions of controlled ventilation. Due to the fact that some of the procedures required muscle relaxation 7,8 , and to provide homogenous conditions for device insertion, we decided to administer a nondepolarizing muscle blocker to all patients. The primary outcome measure was seal pressure.…”

Section: Introductionmentioning

confidence: 99%

I-Gel(tm) vs. Auraonce(tm) Laryngeal Mask for General Anaesthesia With Controlled Ventilation in Paralyzed Patients

Donaldson¹,

Abraham²,

Deighan³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…This result seems to be caused by the higher number of female patients in this study [17,18]. There are differences in terms of the pharmacodynamics of the drug used for anesthesia depending on gender and it has been reported that females were 20-30% more sensitive to muscle relaxant than males [17,18]. …”

Section: Discussionmentioning

confidence: 86%

The effect of phenylephrine on the onset time of rocuronium

Won

Shin

Lee

et al. 2010

Korean J Anesthesiol

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BackgroundSeveral studies have demonstrated that ephedrine shortens the onset time of muscle relaxants, and it does so probably by increasing the cardiac output. However, elevation of the systemic blood pressure through α adrenergic stimulation via ephedrine may affect the onset of muscle relaxants during the induction of anesthesia. We investigated the effect of phenylephrine, which is a selective α-1 agonist, on the onset time of rocuronium and the intubating conditions in adults after the administration of propofol.MethodsSixty-four patients were randomly assigned to two groups. Phenylephrine (0.9 µg/kg) (P group) or the same volume of saline (S group) was injected before rocuronium (0.6 mg/kg) administration. Anesthesia was induced with fentanyl 2 µg/kg and propofol 2 mg/kg. The onset time was defined as the time from the end of rocuronium injection to the time when a single twitch height gets to 0% or the minimum level. A well-trained anesthesiologist who was 'blinded' to the treatment groups evaluated the intubating conditions. The mean arterial pressure and heart rate were recorded before induction, before intubation, immediately after intubation and 1 minute and 2 minutes after intubation.ResultsThe onset time was 84 ± 18 sec in the P-group and 72 ± 14 sec in the S-group. There was no difference of the intubating conditions, the mean arterial pressure and the heart rate between the two groups.ConclusionsA small dose of phenylephrine, which has a limited effect on blood pressure, delayed the onset time of rocuronium after the administration of propofol, and the vasoconstriction effect of phenylephrine may affect the prolongation of the rocuronium onset time at the induction of anesthesia with using propofol.

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Influence of Gender on the Onset and Duration of Rocuronium-Induced Neuromuscular Block

Cited by 11 publications

References 23 publications

The effect of gender on reversal of non-depolarizing block with Sugammadex

The effect of gender on reversal of non-depolarizing block with Sugammadex

I-Gel(tm) vs. Auraonce(tm) Laryngeal Mask for General Anaesthesia With Controlled Ventilation in Paralyzed Patients

The effect of phenylephrine on the onset time of rocuronium

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