Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium

Adamus, Milan; Gabrhelík, Tomáš; Marek, O.

doi:10.1017/s026502150800402x

Cited by 44 publications

(43 citation statements)

References 28 publications

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“…Women appear to be more susceptible of nausea and vomiting following opioids analgesics [17]. Women are more sensitive to neuromuscular blocking drugs [18]. Contrary to this men are more sensitive to propofol [19].…”

Section: Resultsmentioning

confidence: 99%

Influences of Gender on Postoperative Morphine Consumption

Periasamy

Poovathai

Pondiyadanar

2014

JCDR

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Section: Resultsmentioning

confidence: 99%

Influences of Gender on Postoperative Morphine Consumption

Periasamy

Poovathai

Pondiyadanar

2014

JCDR

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“…We used standardized anesthetic techniques in all patients 5 . The patients were premedicated orally with diazepam 5-10 mg 1 h before the beginning of surgery.…”

Section: Anesthesiamentioning

confidence: 99%

“…The drug dose is usually calculated according to patient body weight. However, the effect of a number of anesthetic agents, including aminosteroidal NMBAs, can be influenced by a large number of other factors including gender 4,5 and age [6][7][8] . The aim of this study was to compare the pharmacodynamics (PD) of the rocuronium, following a single dose (0.6 mg kg -1 ) in young and older males and females during total intravenous anesthesia (TIVA).…”

Section: Introductionmentioning

confidence: 99%

Influence of Age and Gender on the Pharmacodynamic Parameters of Rocuronium During Total Intravenous Anesthesia

Adamus

Hrabálek²,

Wanek³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims.To compare the pharmacodynamics of 0.6 mg kg -1 rocuronium in young and older patients of both genders during total intravenous anesthesia.Methods. Following local ethics committee approval and informed consent, patients scheduled for surgery under total intravenous anesthesia (propofol/sufentanil) were divided into 4 study groups: 37 males aged 20-40, 40 males aged 60-75 yrs, 43 females aged 20-40 and 38 females aged 60-75 yrs. Neuromuscular block following rocuronium (0.6 mg kg -1 ) was monitored: train-of-four [TOF] stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis muscle. The onset time (from application of rocuronium to maximum depression of T 1 ), clinical duration (from application to 25% recovery of T 1 ), and time to full spontaneous recovery (from application to TOF-ratio ≥ 0.9) were determined for each patient. The Kruskal-Wallis test was used to compare differences between groups; P<0.05 was considered statistically significant.Results.

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“…9 The onset time, duration of action and recovery profile of cisatracurium is not affected by gender. 10 The use of inhaled anaesthetics (like desflurane, sevoflurane) during anaesthesia induction and maintenance found to augment the neuromascular blocking effects of cisatracurium as compared with total i.v. anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

A clinical comparative study of two intubating doses of cis-atracurium during general anaesthesia for gynaecological surgery

Jammar

Pathak

Begum

et al. 2017

Int J Basic Clin Pharmacol

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INTRODUCTIONCisatracurium besilate is a cis-cis isomer (51W89:1R-cis 1'R-cis atracurium), one of the 10 stereoisomers of atracurium that constitutes 15% of the atracurium mixture, an intermediate duration non-depolarising neuromuscular blocking drug. It is about three to four times more potent than atracurium and devoid of cardiovascular side effects in doses of upto 8 times of ED95. The ED95 of cisatracurium is 0.05mg/kg. 1-5The rate limiting step in the degradation of cisatracurium is Hoffmann degradation.(organ independent elimination) to form laudanosine and monoquaternary alcohol. 77% of drug is cleared via Hoffmann degradation which is a ph and temperature dependent process, rest 23% of drug get cleared through organ dependent means, and renal elimination accounts for 16% of this. Hydrolysis by non-specific esterases is not an important pathway for cisatracurium degradation. It is not associated with histamine release in humans. Although the liver and kidneys play only a small role in the excretion of cisatracurium besilate, urinary and hepatic elimination pathways are important for the metabolites of laudanosine. 5-8The total body clearance (CL), steady-state Vd and elimination half-life of cisatracurium besilate in patients with normal organ function are approximately 0.27 to 0.34 L/h/kg (4.7 ml/min/kg), 0.11 to 0.16 L/kg and 22 to 35 minutes, respectively. The volume of distribution (Vd) ABSTRACT Background: Cisatracurium is one of the cis-cis isomer of atracurium (51W89:1R-cis 1'R-cis atracurium) an intermediate duration non-depolarising neuromuscular blocking drug and is devoid of histamine release. However, 2× ED95 dose of cisatracurium does not provide satisfactory intubating condition. The recommended intubating dose of cisatracurium is 3 ×ED95. The objective of this study was to evaluate and compare duration of action, hemodynamic effects and any adverse effects for different doses of cisatracurium. Methods: After Institutional Ethical Committee approval and informed patient consent, 80 patients of ASA I and II in the age group of 20-60 years were selected and included in the study. Patients were divided in two groups of 40 each, group A received intravenously 3×ED95 (0.15 mg/kg) loading dose of cisatracurium and group B received intravenously 4×ED95 (0.2 mg/kg) loading dose of cisatracurium. Results: After induction, MAP and HR shows decrease in both groups but neither statistically nor clinically significant. Better hemodynamic stability and longer duration of action was found in group B compared to group A. No adverse effects noted in both groups. Conclusions: 4×ED95 dose of cisatracurium provides longer duration of action and more stable hemodynamic status than 3×ED95. No associated signs of histamine release were detected clinically.

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Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium

Cited by 44 publications

References 28 publications

Influences of Gender on Postoperative Morphine Consumption

Influences of Gender on Postoperative Morphine Consumption

Influence of Age and Gender on the Pharmacodynamic Parameters of Rocuronium During Total Intravenous Anesthesia

A clinical comparative study of two intubating doses of cis-atracurium during general anaesthesia for gynaecological surgery

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