Influence of gender on continuous positive airway pressure requirements in patients with obstructive sleep apnea syndrome

Jayaraman, Gnananandh; Majid, Hafsa; Surani, Salim; Kao, Christina C.; Subramanian, Shyam

doi:10.1007/s11325-010-0436-2

Cited by 41 publications

(22 citation statements)

References 21 publications

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“…A cross-sectional Japanese case-control study, however, observed that female patients require significantly lower levels of CPAP than male patients matched for BMI [44]. A more recent US study confirmed these findings and the effect of gender persisted after correction for the severity of OSA [45]. This observation is in line with evidence of a lower pharyngeal critical closing pressure in women.…”

Section: Symptoms Of Osas In Men and Women !mentioning

confidence: 66%

Gender-related Differences in the Obstructive Sleep Apnea Syndrome

Valipour

2012

Pneumologie

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The obstructive sleep apnea syndrome (OSAS) is associated with increased morbidity and mortality. Epidemiological studies suggest a two-fold higher prevalence of OSAS in men than in women. Differences in pharyngeal collapsibility and central respiratory drive may play a significant role in the gender-specific pathogenesis. Compared with their male counterparts, female patients experience OSAS at an older age (postmenopausal) and with higher body-mass-index. Female OSAS patients furthermore more frequently report atypical symptoms, such as insomnia, depression, and/or restless legs, and thus are less likely to be referred for the evaluation of sleep disordered breathing. Knowledge about these distinct gender-related differences in clinical features of OSAS may contribute to an increased awareness, improved diagnosis and its therapeutic consequences.

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Section: Symptoms Of Osas In Men and Women !mentioning

confidence: 66%

Gender-related Differences in the Obstructive Sleep Apnea Syndrome

Valipour

2012

Pneumologie

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“…77,78 The positive airway pressure (PAP) requirements however seem to be higher for males than females, after adjusting for baseline OSA severity and BMI. 79,80 No significant difference has been observed in terms of types of interface used or satisfaction with mask treatment in males and females. 81 Studies are ongoing to determine the efficacy of PAP devices that have algorithms targeting femalespecific characteristics.…”

Section: Treatmentmentioning

confidence: 95%

Obstructive Sleep Apnea in Women

Ayub

Won

2019

J Sleep Med

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Obstructive sleep apnea is known to be more prevalent in men. In women the prevalence varies throughout her life span as she goes through different stages; puberty, reproductive years, pregnancy and postmenopausal state. The disparity of prevalence within the lifespan of women and in comparison, to men is not only due to different pathophysiologic factors like upper airway anatomy, chemoreflexes, sex hormones but also due to under recognition of sleep disordered breathing in women due to atypical presentation and difference in polysomnographic phenotypes. This review summarizes the literature regarding sleep-disordered breathing in women, its pathophysiology, sex differences in phenotypes and implications of sex differences on management.

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“…Regardless of the patient’s gender, there is also significant night-to-night variation in OSA, based on factors such as body posture, sleep stages, and previous drug or alcohol intake [ 28 ]. Besides OSA pathophysiology, gender influences also patients’ PAP requirements [ 29 ], as generally female patients require lower pressures. Such considerable variability between phenotypes highlights the relevance of the simulation approach taken in this study.…”

Section: Discussionmentioning

confidence: 99%

Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices

et al. 2016

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Bench testing is a useful method to characterize the response of different automatic positive airway pressure (APAP) devices under well-controlled conditions. However, previous models did not consider the diversity of obstructive sleep apnea (OSA) patients’ characteristics and phenotypes. The objective of this proof-of-concept study was to design a new bench test for realistically simulating an OSA patient’s night, and to implement a one-night example of a typical female phenotype for comparing responses to several currently-available APAP devices. We developed a novel approach aimed at replicating a typical night of sleep which includes different disturbed breathing events, disease severities, sleep/wake phases, body postures and respiratory artefacts. The simulated female OSA patient example that we implemented included periods of wake, light sleep and deep sleep with positional changes and was connected to ten different APAP devices. Flow and pressure readings were recorded; each device was tested twice. The new approach for simulating female OSA patients effectively combined a wide variety of disturbed breathing patterns to mimic the response of a predefined patient type. There were marked differences in response between devices; only three were able to overcome flow limitation to normalize breathing, and only five devices were associated with a residual apnea-hypopnea index of <5/h. In conclusion, bench tests can be designed to simulate specific patient characteristics, and typical stages of sleep, body position, and wake. Each APAP device behaved differently when exposed to this controlled model of a female OSA patient, and should lead to further understanding of OSA treatment.

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Influence of gender on continuous positive airway pressure requirements in patients with obstructive sleep apnea syndrome

Abstract: Men with OSA are more likely to require higher levels of CPAP support than women. The effect of gender on CPAP requirement persisted even after correcting for the severity of OSA.

Cited by 41 publications

References 21 publications

Gender-related Differences in the Obstructive Sleep Apnea Syndrome

Gender-related Differences in the Obstructive Sleep Apnea Syndrome

Obstructive Sleep Apnea in Women

Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices

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