Influence of Gender on Clinical Characteristics and Outcomes in Chinese Patients With Hypertrophic Cardiomyopathy

Huang, Fang‐Yang; Shah, Jageshwar Prasad; Pu, Xiaobo; Hagar, Abdullah; Chen, Shijian

doi:10.1016/j.amjms.2020.05.017

Cited by 8 publications

(11 citation statements)

References 30 publications

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“…Twenty-one studies were excluded due to reasons given in the PRISMA flow diagram in Figure 1. Therefore, 11 studies were included in this meta-analysis [11,12,[22][23][24][25][26][27][28][29][30].…”

Section: Literature Searchmentioning

confidence: 99%

“…Outcomes regarding all-cause mortality were available in 7 studies [11,12,24,25,27,28,30]. Female gender was associated with a higher risk of all-cause mortality (pooled OR = 1.63, 95% CI: 1.26-2.10, p ≤ 0.001, I 2 = 35%).…”

Section: All-cause Mortalitymentioning

confidence: 99%

“…Outcomes regarding HCM-related mortality were available in 10 studies [11,12,[22][23][24][26][27][28][29][30]. Female gender was significantly associated with an increased risk of HCM-related mortality (pooled OR = 1.47, 95% CI: 1.08-2.01, p = 0.015, I 2 = 43%).…”

Section: Hcm-related Mortalitymentioning

confidence: 99%

“…Worsening HF or HF Hospitalization Outcomes regarding worsening HF or HF hospitalization were available in 7 studies [11,12,22,25,[28][29][30]. Female gender was associated with worsening HF or HF hospitalization than male gender (pooled OR = 2.05, 95% CI: 1.76-2.39, p ≤ 0.001, I 2 = 0%).…”

Section: Hcm-related Mortalitymentioning

confidence: 99%

“…Some studies reported that women had a worse prognosis [8][9][10]. On the other hand, some studies reported no differences regarding the rates of mortality [11,12]. Thus, we conducted a systematic review and meta-analysis to assess the differences in clinical outcomes including allcause mortality, HCM-related mortality, and worsening HF or HF hospitalization between women and men with HCM.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Gender-Related Differences in Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis

Trongtorsak

Polpichai

Thangjui

et al. 2021

Pulse

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Background: Gender-related differences in phenotypic expression and outcomes have been established in many cardiac conditions; however, the impact of gender in hypertrophic cardiomyopathy (HCM) remains unclear. We conducted a systematic review and meta-analysis to assess the differences in clinical outcomes between female and male HCM patients. Methods: We searched MEDLINE and EMBASE from inception to October 2020. Included were cohort studies that compared outcomes of interest including all-cause mortality, HCM-related mortality, and worsening heart failure (HF) or HF hospitalization between male and female. Data from each study were combined using the random effects model to calculate pooled odds ratio (OR) with 95% confidence interval (CI). Results: Eleven retrospective cohort studies with a total of 9,427 patients (3,719 females) were included. Female gender was significantly associated with an increased risk of all-cause mortality (pooled OR = 1.63, 95% CI: 1.26–2.10, p ≤ 0.001), HCM-related mortality (pooled OR = 1.47, 95% CI: 1.08–2.01, p = 0.015), and worsening HF or HF hospitalization (pooled OR = 2.05, 95% CI: 1.76–2.39, p ≤ 0.001). Conclusions: Female gender was associated with a worse prognosis in HCM. These findings suggest the need for improved care in women including early identification of disease and more possible aggressive management. Moreover, gender-based strategy may benefit in HCM patients.

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