Influence of gelatin coatings on compressive strength of porous hydroxyapatite ceramics

Processing of highly porous TiO2 bone scaffolds with improved compressive strength

“…32 However, even after 2 h of sintering at 1500 • C, the three walls of the struts of the prepared TiO 2 foams formed a uniform structure and the typical longitudinal cracks at the edges were a relatively rare finding. This was due to the high sintering rate of the TiO 2 particles, manifested by the large overall grain size of the strut walls observed even after the shorter holding times (2-5 h), at the applied sintering temperature of 1500 • C. The densification induced by the high sinterability of TiO 2 led to reduction in the initial volume of the hollow strut interior as the corners of the strut walls sintered together, causing one of the three walls to bend inwards.…”

“…29,30 In addition, the replication process typically results in several lateral cracks alongside the highly curved edges of the foams struts due to the poor slurry coverage at such location and the low resistance of these narrow strut edges to stresses induced by the thermal expansion mismatch of the polymer template and the ceramic coating. 31,32 Therefore, reducing the flaw size and distribution in the foams struts has been shown theoretically and experimentally to be a key approach in developing highly porous ceramic foams with improved mechanical properties. 20,[33][34][35] Long sintering times have previously been shown to result in partial elimination of the triangular pores within the struts of highly porous ceramic TiO 2 scaffold structures.…”

Recent advances in the use of gelatin in biomedical research

“…As an example of a simple two-phase composite, porous HA can be coated with gelatin in order to increase construct mechanical properties. This increase was shown to be proportional to the concentration of gelatin, leading to the hypothesis that gelatin increases HA toughness by bridging material cracks (Dressler et al 2011).…”

On the importance of Bloom number of gelatin to the development of biodegradable in situ gelling copolymers for intracameral drug delivery

“…Others have correlated the Bloom index of gelatin with gel strength as determined by ballistic penetration depth (Maiden et al, 2015). Gelatins having high Bloom numbers were also used as coatings for porous hydroxyapatite ceramics to increase the compressive strength (6-fold) (Dressler et al, 2011). Overall, Bloom index is considered as one of the important parameters in studying and designing gelatin-based biomaterials.…”