Influence of Gadoxetate Disodium on Oxygen Saturation and Heart Rate during Dynamic Contrast-enhanced MR Imaging

Abstract

Intravenous gadoxetate disodium (a weight-based dose) does not cause changes in SpO2 and HR that lead to image quality degradation.

Transient Severe Respiratory Motion Artifacts After Application of Gadoxetate Disodium: What We Currently Know

“…Also, no correlation between the dose of gadoxetate disodium and the frequency of TSM can be derived when indirectly comparing results from different studies and different sites (▶ Table 2). For example, Hayashi et al found the lowest frequency of TSM (5 %), while our group found one of the highest frequencies (21 %), despite the fact that both groups used the same weight-adjusted dose of 0.025 mmol/kg [11].…”

“…The highest frequency (22 %) was observed by Motosugi et al in the USA [13]. Hayashi et al from Japan observed the lowest frequency of TSM (5 %) [11]. As shown in ▶ Table 1, all other studies investigating TSM revealed frequencies over 10 %.…”

“…Both Hayashi et al and Motosugi et al applied the same amount of weight-adapted gadoxetate disodium at a slow rate of 1 ml/s but observed different frequencies of TSM (5 % vs. 13 %) [11,13]. Studies with faster injection rates of 2 ml/s also showed varying, but higher frequencies of TSM, ranging from 10 % to 22 % with either weight-adjusted dosing or fixed doses of 10 ml gadoxetate disodium (▶ Table 2) [6,8,13].…”

“…This assumption might explain the differences in observed frequencies of TSM. Indeed, the study sites addressing TSM used different doses of gadoxetate disodium: weight-adapted doses of 0.025 or 0.05 mmol/kg [11,13] fixed doses of 10 ml (package size) or 20 ml [6,8,10] (▶ Table 2). …”

“…Other institutions administer it with a slower injection rate of 1 ml/s to spread the contrast bolus, thereby reducing the risk of a poorly timed arterial phase [6,10,11,13,25]. Dilution of gadoxetate disodium with saline is an alternative approach to spread the contrast bolus [9].…”