Influence of Fractionation on Acute and Late Reactions in Vocal Cord Carcinoma

Rk, Loeffler

doi:10.2214/ajr.121.4.748

Cited by 13 publications

(2 citation statements)

References 11 publications

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“…In vergleichenden Untersuchungen konnte gezeigt werden, daß bei erhöhten täglichen Strahlendosen und dadurch verkürzter Protokolldauer die Häufigkeit der chronischen Ödeme im Larynx und Pharynx ansteigt [5,12,14,22].…”

Section: Diskussionunclassified

Das chronische Larynxödem als Spätreaktion nach Radiochemotherapie

Dietz

Rudat

Nollert

et al. 1998

HNO

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In addition to mucositis and myelotoxicity as well known early reactions after radiotherapy or radiochemotherapy in advanced head and neck tumors, late toxicity following treatment is an often underestimated problem. Between 1992 and 1995, 68 patients with advanced oro- and hypopharyngeal tumors were treated primarily with accelerated concomitant boost radiochemotherapy (total dose irradiations of 66 Gy and carboplatin as chemotherapy). Ninety-three per cent of the patients had stage IV disease according to the UICC-TNM classification. Monitoring of follow-up included late toxicity with special attention given to laryngeal edema. In 37 patients (54%) edema of the larynx as a late complication of radiochemotherapy was observed by clinical investigation and CT scan. The median onset of laryngeal edema was found 121 days after completion of therapy, with a median time of observation of 250 days. Observations in these patients demonstrated the chronic character of this edema. An increase in the laryngeal edema in 5 cases resulted in tracheostomy. Laryngeal edema in 10 patients was associated with recurrence of tumor. These results show that after xerostomia laryngeal edema is the main late toxicity in the head and neck after radiochemotherapy and should lead to further investigations to exclude possible recurrent tumor.

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Section: Diskussionunclassified

Das chronische Larynxödem als Spätreaktion nach Radiochemotherapie

Dietz

Rudat

Nollert

et al. 1998

HNO

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“…18-'0 Most authors suggest that the dose-response curve for local control of T1 VCC is nearly flat between 5,500 and 6,600 rad. 23 We found that TDF of 101 to 106 yielded good local control and that exceeding a TDF of 106 led to an increase in chronic laryngeal edema and radionecrosis. The literature suggests that exceeding 2,000 rets, which corresponds to a TDF of approximately 120, leads to more than 5% r a d i o n e~r o s i s .~~,~~,~~ Our study does not substantiate a recent report that a field size greater than 5 x 5 cm2 (equivalent square) results in improved local contr01.l~ Field sizes beyond 6 to 7 cm (side of equivalent square field) are associated with increased chronic laryngeal edema if the TDF exceeds Treatment factors in our series appear statistically more pertinent than knowledge of tumor factors in predicting local control outcome.…”

Section: Discussionmentioning

confidence: 69%

Local control of T₁ vocal cord cancer with radiation therapy: The importance of tumor character VS. Treatment parameters

et al. 1983

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Ninety-one patients with T1 vocal cord carcinoma received primary irradiation treatment. The 5- and 10-year determinate disease-free survival was 80%; the 5- and 10-year determinate survival including surgical salvage was 92%. Tumors involving more than one-half of a vocal cord or involving the anterior commissure or exhibiting an exophytic growth pattern had numerically, but not statistically, higher local failure rates than tumors without these characteristics. Precise radiation treatment technique appears more important for local control (LC) than tumor character. The crucial treatment factors for high LC with few radiation complications are reproducible daily patient positioning, use of contour-compensating devices (wedges), field size of 5 X 5 cm, and a radiation prescription with a time-dose fractionation value of 101 to 106.

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Effect of Radiation Fraction Size on Local Control Rates for Early Glottic Carcinoma: A Model Analysis for In Vivo Tumor Growth and Radioresponse Parameters

Ricciardelli

Weymuller²,

Koh³

et al. 1994

Archives of Otolaryngology - Head and Neck Surgery

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Influence of Fractionation on Acute and Late Reactions in Vocal Cord Carcinoma

Cited by 13 publications

References 11 publications

Das chronische Larynxödem als Spätreaktion nach Radiochemotherapie

Das chronische Larynxödem als Spätreaktion nach Radiochemotherapie

Local control of T₁ vocal cord cancer with radiation therapy: The importance of tumor character VS. Treatment parameters

Effect of Radiation Fraction Size on Local Control Rates for Early Glottic Carcinoma: A Model Analysis for In Vivo Tumor Growth and Radioresponse Parameters

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Influence of Fractionation on Acute and Late Reactions in Vocal Cord Carcinoma

Cited by 13 publications

References 11 publications

Das chronische Larynxödem als Spätreaktion nach Radiochemotherapie

Das chronische Larynxödem als Spätreaktion nach Radiochemotherapie

Local control of T1 vocal cord cancer with radiation therapy: The importance of tumor character VS. Treatment parameters

Effect of Radiation Fraction Size on Local Control Rates for Early Glottic Carcinoma: A Model Analysis for In Vivo Tumor Growth and Radioresponse Parameters

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Product

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Local control of T₁ vocal cord cancer with radiation therapy: The importance of tumor character VS. Treatment parameters