Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT1A agents in mice

Briones-Aranda, Alfredo; López‐Rubalcava, Carolina; Picazo, Ofir Picazo

doi:10.1007/s00213-002-1046-x

Cited by 19 publications

(4 citation statements)

References 71 publications

(89 reference statements)

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“…The low dose of E-6837 reversed the increase in climbing behavior found with ketamine, a result not observed with the high dose. These findings coincide with a previous report of bidirectional effects on the level of anxiety recorded in mice that had been stressed and treated with distinct doses of buspirone, a partial 5-HT1A agonist (Briones-Aranda et al, 2002). This evidence indicates the importance of external factors in the regulation of specific behaviors as ketamine treatment (Ikeda et al, 2011) and stress (Briones et al, 2015) increase the concentration of brain DA and 5-HT, which in turn could influence the actions of nonselective serotonergic agents.…”

Section: Discussionsupporting

confidence: 89%

Effect of ketamine administration, alone and in combination with E-6837, on climbing behavior

Briones-Aranda

Suárez-Santiago

Picazo

et al. 2016

Behavioural Pharmacology

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Some types of schizophrenia have been associated with repetitive movements lacking specific purpose, also known as stereotyped behavior. Dopamine agonists (D2) and noncompetitive N-methyl-D-aspartate receptor antagonists (e.g. ketamine) have been administered in rodent models to induce stereotyped behavior that resembles some motor symptoms of schizophrenia. Recently, a relationship has been found between 5-HT6 receptors (5-HT6Rs) and dopaminergic activity. The present study evaluates the effect of ketamine (5 and 10 mg/kg), alone and in combination with the 5-HT6R agonist E-6837, on the climbing behavior of male mice. Ketamine was administered with an acute (1 day) and subchronic (5 day) scheme. Later, these doses and schemes were combined with an acute scheme of E-6837 (5 and 10 mg/kg). With both the acute and the subchronic schemes, ketamine increased climbing behavior at a dose of 10 mg/kg, and this effect was reversed by E-6837 (at 5 and 10 mg/kg). The present results suggest that there is an interaction between N-methyl-D-aspartate and 5-HT6 receptors in the regulation of climbing behavior. Further research is necessary to provide more evidence on this interaction.

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Section: Discussionsupporting

confidence: 89%

Effect of ketamine administration, alone and in combination with E-6837, on climbing behavior

Briones-Aranda

Suárez-Santiago

Picazo

et al. 2016

Behavioural Pharmacology

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“…BDNF regulates synaptic transmission and activitydependent plasticity (Bramham & Messaoudi, 2005 ;Gottmann et al 2009), promotes neurogenesis (Scharfman et al 2005) and exerts an antidepressant activity in a time-dependent manner, as it has been shown that a single bilateral infusion of BDNF into the dentate gyrus of the hippocampus produces an antidepressant-like effect in both the learned helplessness paradigm and FST, within 3 d after infusion (Shirayama et al 2002). Importantly, pre-training stressors that affect behavioural response induce neuronal plasticity changes (Briones-Aranda et al 2002 ;Chaki et al 2004 ;Consoli et al 2005 ;Drago et al 2001 ;Micale et al 2008b ;Pittenger & Duman, 2008 ;Tamburella et al 2010 ;Teixeira & de Lima, 2003).…”

Section: Discussionmentioning

confidence: 94%

“…Because stressful life events are major predisposing risk factors for developing depression, preclinical studies should take into account both the effects of pre-training stressors, such as drug injection procedure, inescapable foot-shocks, restraint and forced swim on the behavioural and neuroendocrine responses of animals, and the influence of these stressful stimuli on anxiolytic and/or antidepressant drug action (Briones-Aranda et al 2002 ;Consoli et al 2005 ;de Kloet et al 2005 ;Drago et al 2001 ;McEwen, 2005 ;Micale et al 2008a ;Tamburella et al 2010 ;Teixeira & de Lima, 2003).…”

Section: Introductionmentioning

confidence: 99%

Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant

Tamburella

Leggio

Micale

et al. 2013

International Journal of Neuropsychopharmacology

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These experiments were undertaken to assess the mechanisms underlying the antidepressant-like effects of the neurokinin-2 (NK(2)) receptor antagonist saredutant (SR48968) in rats tested in the forced swim test (FST), by analysing hippocampal brain-derived neurotrophic factor (BDNF) and plasma corticosterone [as index of hypothalamic-pituitary-adrenal (HPA) axis activity]. Male Wistar rats received three intraperitoneal injections over 24 h of vehicle, saredutant (5 mg/kg), citalopram (15 mg/kg), clomipramine (50 mg/kg). Rats were subjected to restraint stress (4 h) 24 h prior to the FST procedure. This stress procedure increased immobility and decreased swimming behaviour in the FST; furthermore, it lowered hippocampal BDNF protein expression and increased plasma corticosterone levels. Saredutant and clomipramine or citalopram, used here as positive controls, reduced the immobility time in the FST both under basal conditions and after stress exposure. This effect was not attributable to changes in locomotion, because locomotor activity was unchanged when assessed in the open field test. Pretreatment with para-cholorophenylalanine (150 mg/kg, 72 h and 48 h prior to FST) abolished the effect of citalopram and saredutant on immobility time. At neurochemical level, saredutant attenuated activation of HPA axis in stressed animals more than clomipramine or citalopram. The behavioural effects of saredutant support the hypothesis that NK(2) receptor activity is involved in stress-related disorders. These effects of saredutant may be related to normalization of the HPA axis. Moreover, saredutant increases BDNF expression in the hippocampus, confirming the role of NK(2) receptor blockade in BDNF activation following stressor application.

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“…Present animal models and tests most likely provide partial data about the behavior under study. For example, different tests of anxiety-like behaviors in rodents and different methodological approaches show distinct predictive validity and non-similar effects of anxiogenic or anxiolytic pharmacological compounds [130][131][132]. Moreover, our first experimental approach has been applied to test the behavior of adult males to avoid confounding variations due to cyclical changes in circulating sex hormones [40,65,133].…”

Section: Functional Features Of the Medial Amy-gdalamentioning

confidence: 99%

Morphological and Functional Features of the Sex Steroid-Responsive Posterodorsal Medial Amygdala of Adult Rats

Rasia‐Filho

Haas²,

Oliveira³

et al. 2012

MRMC

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The rat posterodorsal medial amygdala (MePD) expresses receptors for gonadal hormones and integrates sex steroid-sensitive subcortical networks. Male-female differences are found in the morphology, connectivity, and local neuropil structure of MePD. For example, dendritic spine density is sexually-dimorphic and changes with the estrous cycle and following gonadal hormones manipulations. Due to its connectivity, the MePD may affect emotionally-loaded social behaviors, according to a former Newman's seminal proposition. Unilateral fiber-sparing ibotenic acid damage of the MePD does not impair male sexual behavior. However, microinjecting glutamate and histamine into the right MePD facilitates ejaculation. Further, MePD-lesioned rats are not different from normal rats in anxiety-like behavior as evaluated by the elevated plus maze test or innate fear test induced by a live cat. In another study, an adapted model for inducing aggressive behavior in rats by a brief period of restraint prior to the resident-intruder paradigm was used to study Fos-immunoreactivity in the MePD. Following stressful stimulation (restraint) or the restraint and fight condition, but not after aggression alone, Fos-immunoreactivity was detected in the MePD. Microinjecting the inhibitory neuropeptide somatostatin into the right MePD notably reduces fighting behavior without affecting locomotion. Overall, these data indicate that sex steroids and local neurochemical stimulatory/inhibitory transmitters modulate the MePD and reinforce the idea that this area is a node for modulating social behavior neural networks.

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Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT1A agents in mice

Abstract: The present data provide evidence that FS induces changes in the effect of 5-HT(1A) agents. The participation of the 5-HT and/or GABA systems in these stress-induced effects is discussed.

Cited by 19 publications

References 71 publications

Effect of ketamine administration, alone and in combination with E-6837, on climbing behavior

Effect of ketamine administration, alone and in combination with E-6837, on climbing behavior

Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant

Morphological and Functional Features of the Sex Steroid-Responsive Posterodorsal Medial Amygdala of Adult Rats

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