Influence of Food Intake Frequency on 26-14C-Cholesterol Turnover in Pullets Fed a Basal and Cholesterol-enriched Diet

Influence of meal pattern and dietary fat on cholesterol metabolism in adult rats recovering from undernutrition

“…Thus the assumption was made that bile acid synthesized from cholesterol in the liver and excreted in feces was also of reduced S.A., and therefore, that *^C-label recovered underestimated bile acid excretion in meal fed rats. In Experiment 3, hepatic cholesterol S.A. was not in fluenced by feeding frequency and neither was excretion of total acid steroid label in agreement with Bobek et al (1972Bobek et al ( , 1973a.…”

“…In another study, meal feeding shortened plasma cholesterol half life and raised fractional cholesterol turnover rate following injection of 26-^C -cholesterol (Bobek et al, 1973a). …”

“…The experimental model used by Bobek and coworkers to study cholester ol metabolism with decreased feeding frequency may be criticized since serum and liver cholesterol concentrations are not altered by meal pattern (Bobek et al, 1972;Bobek et al, 1973a). Pre-experlmental Male adult Wistar rats from the stock colony of this department were used in all three studies.…”