Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model

Blasco, Víctor; Prados, Nicolás; Carranza, F.; González-Ravina, Cristina; Pellicer, António; Sánchez, Manuel Fernández

doi:10.1016/j.fertnstert.2014.06.031

Cited by 12 publications

(11 citation statements)

References 35 publications

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“…A group of researchers found that clinical pregnancy was significantly higher when follicle rupture was detected just after the IUI procedure, in comparison to those cases in which follicle rupture was not detected [77]. Subsequent studies confirmed this finding [76,78]. In one of these studies, the authors only found a higher pregnancy rate in association with follicle rupture when analyzing cases of non-male factor etiology, but not when comparing cases with a male factor etiology.…”

Section: Follicle Rupture and Intrauterine Inseminationmentioning

confidence: 99%

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How to Perform the Best Intrauterine Insemination? A Review

Carranza¹,

Santamaría²

2015

Andrology (Los Angel)

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Intrauterine insemination is a treatment used in couples with mild/moderate male factor, when female partner has at least one tube patent. Numerous studies have attempted to determine for many years which parameters are limiting to ensure pregnancy with this technique of assisted reproduction. This review focuses on prognostic factors for a successful outcome, as semen quality, female etiology, synchronization with ovulation, assessment of follicle rupture, number of inseminations per cycle and influence of uterine contractions. We conclude with this review that intrauterine insemination is a less invasive and expensive option than others [IVF], with acceptable results when adequately indicated. We conclude with this review that intrauterine insemination can be performed when patient is less than 40 years old and there are at least 5 million of motile sperm to be inseminated. The abstinence interval of 3 days prior to produce the sperm sample is the optimal period and either one or two inseminations are valid, ideally performed in the frame time between 12 and 38 hours after ovulation induction. Also, follicle rupture and uterine contractions observed by ultrasound scan following intrauterine inseminations are favorable prognostic factors.

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Section: Follicle Rupture and Intrauterine Inseminationmentioning

confidence: 99%

“…Therefore, physicians may use the ultrasound detection of follicle rupture after performing IUI as an additional tool to predict the success of the cycle [78].…”

Section: Follicle Rupture and Intrauterine Inseminationmentioning

confidence: 99%

How to Perform the Best Intrauterine Insemination? A Review

Carranza¹,

Santamaría²

2015

Andrology (Los Angel)

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“…CRISP1, a sperm protein expressed by the cumulus cells surrounding the oocyte, stimulates sperm orientation through the modulation of sperm hyperactivation and it seems to regulate CatSper ( 53 ). Recent studies have revealed an oocyte-derived chemotactic activity associated with a hydrophobic non-peptide molecule in human sperm ( 54 ) and an association between follicle rupture and uterine contractions with the success of human in vivo insemination, suggesting the existence of possible chemoattractive substances in the female tract ( 55 ). It is not clear if there is a binding partner on the oocyte membrane for sperm-associated CRISP protein, along with the exact mechanisms through which gamete binding is achieved.…”

Section: The Three Stages Of Fertilizationmentioning

confidence: 99%

The molecular basis of fertilization (Review)

Georgadaki

Khoury

Spandidos

et al. 2016

International Journal of Molecular Medicine

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Fertilization is the fusion of the male and female gamete. The process involves the fusion of an oocyte with a sperm, creating a single diploid cell, the zygote, from which a new individual organism will develop. The elucidation of the molecular mechanisms of fertilization has fascinated researchers for many years. In this review, we focus on this intriguing process at the molecular level. Several molecules have been identified to play a key role in each step of this intriguing process (the sperm attraction from the oocyte, the sperm maturation, the sperm and oocyte fusion and the two gamete pronuclei fusion leading to the zygote). Understanding the molecular mechanisms of the cell-cell interactions will provide a better understanding of the causes of fertility issues due to fertilization defects.

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“…Interestingly, an olfactory receptor whose function seems to be critical for chemotaxis was identified, cloned and shown to be functionally expressed in human testicular sperm ( Spehr et al ., 2003 ). Finally, two recent findings showed an oocyte-derived chemotactic activity associated with a hydrophobic nonpeptide molecule in human sperm ( Armon et al ., 2014 ) and an association between follicle rupture and uterine contractions with the success of human in vivo insemination suggests the existence of possible chemoattractive substances in the female tract ( Blasco et al ., 2014 ).…”

Section: Sperm Activationmentioning

confidence: 99%

Gamete activation: basic knowledge and clinical applications

Tosti

Ménézo²

2016

Hum. Reprod. Update

109

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BackgroundThe first clues to the process of gamete activation date back to nearly 60 years ago. The mutual activation of gametes is a crucial event during fertilization. In the testis and ovaries, spermatozoa and oocytes are in a state of meiotic and metabolic quiescence and require reciprocal signals in order to undergo functional changes that lead to competence for fertilization. First, the oocyte activates sperm by triggering motility, chemoattraction, binding and the acrosome reaction, culminating with the fusion of the two plasma membranes. At the end of this cascade of events, collectively known as sperm capacitation, sperm-induced oocyte activation occurs, generating electrical, morphological and metabolic modifications in the oocyte.Objective and rationaleThe aim of this review is to provide the current state of knowledge regarding the entire process of gamete activation in selected specific animal models that have contributed to our understanding of fertilization in mammals, including humans. Here we describe in detail the reciprocal induction of the two activation processes, the molecules involved and the mechanisms of cell interaction and signal transduction that ultimately result in successful embryo development and creation of a new individual.Search methodsWe carried out a literature survey with no restrictions on publication date (from the early 1950s to March 2016) using PubMed/Medline, Google Scholar and Web of Knowledge by utilizing common keywords applied in the field of fertilization and embryo development. We also screened the complete list of references published in the most recent research articles and relevant reviews published in English (both animal and human studies) on the topics investigated.OutcomesLiterature on the principal animal models demonstrates that gamete activation is a pre-requisite for successful fertilization, and is a process common to all species studied to date. We provide a detailed description of the dramatic changes in gamete morphology and behavior, the regulatory molecules triggering gamete activation and the intracellular ions and second messengers involved in active metabolic pathways in different species. Recent scientific advances suggest that artificial gamete activation may represent a novel technique to improve human IVF outcomes, but this approach requires caution.Wider implicationsAlthough controversial, manipulation of gamete activation represents a promising tool for ameliorating the fertilization rate in assisted reproductive technologies. A better knowledge of mechanisms that transform the quiescent oocyte into a pluripotent cell may also provide new insights for the clinical use of stem cells.

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Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model

Cited by 12 publications

References 35 publications

How to Perform the Best Intrauterine Insemination? A Review

How to Perform the Best Intrauterine Insemination? A Review

The molecular basis of fertilization (Review)

Gamete activation: basic knowledge and clinical applications

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