When a high-power laser beam is incident on water clouds, often along with the optical breakdown phenomenon that occurs. Simultaneously, the droplet becomes highly opaque and strongly absorbs incident laser light. In this study, we construct a transient coupling model to elucidate the evolution of the light field and the distribution of plasma in the interaction between laser and cloud droplet in detail, and further quantify the nonlinear absorption of droplet under the action of high-power laser. By combining existing scattering theory, we evaluate the propagation distance of the laser in water cloud systems and the specific light attenuation under different parameters. The results shed light on the optical breakdown process that occurs in water clouds, which has a considerable influence on laser propagation loss. Therefore, it is recommended to use a laser intensity lower than the optical breakdown threshold of droplets in practical applications.