Influence of fiber connectivity in simulations of cardiac biomechanics

Gil, Débora; Arís, Ruth; Borràs, Josep M.; Ramírez, Esmitt; Sebastián, Rafael; Vázquez, Mariano

doi:10.1007/s11548-018-1849-9

Cited by 12 publications

(11 citation statements)

References 26 publications

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“…Large differences can be expected when using literature-based fibre structures and dispersion parameters compared with case LDDMM. Those different results highlight the necessity of use realistic myofibre structure for personalized cardiac modelling as demonstrated in other studies [15,20,21,24]. In case LDDMM, the high active fibre stresses at both epicardial and endocardial surfaces (figure 7a) can potentially enhance the long-axis shortening and also apical twist (figure 6d).…”

Section: Discussionmentioning

confidence: 70%

“…Pluijmert et al [20] found that a change of 8°in myofibre orientation along transmural direction can cause a considerable increase in cardiac pump work (17%). In a recent study, Gil et al [21] compared three different myofibre architectures in an electromechanics bi-ventricular model, one is from a DT-MRI dataset [22], the other two are reconstructed using a rule-based approach [14] with histologically measured myofibre angles [23]. Their results showed that the model with realistic myofibre structure from DT-MRI produces functional scores much closer to healthy ranges than rule-based approaches.…”

Section: Introductionmentioning

confidence: 99%

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Effect of myofibre architecture on ventricular pump function by using a neonatal porcine heart model: from DT-MRI to rule-based methods

et al. 2020

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Myofibre architecture is one of the essential components when constructing personalized cardiac models. In this study, we develop a neonatal porcine bi-ventricle model with three different myofibre architectures for the left ventricle (LV). The most realistic one is derived from ex vivo diffusion tensor magnetic resonance imaging, and other two simplifications are based on rule-based methods (RBM): one is regionally dependent by dividing the LV into 17 segments, each with different myofibre angles, and the other is more simplified by assigning a set of myofibre angles across the whole ventricle. Results from different myofibre architectures are compared in terms of cardiac pump function. We show that the model with the most realistic myofibre architecture can produce larger cardiac output, higher ejection fraction and larger apical twist compared with those of the rule-based models under the same pre/after-loads. Our results also reveal that when the cross-fibre contraction is included, the active stress seems to play a dual role: its sheet-normal component enhances the ventricular contraction while its sheet component does the opposite. We further show that by including non-symmetric fibre dispersion using a general structural tensor, even the most simplified rule-based myofibre model can achieve similar pump function as the most realistic one, and cross-fibre contraction components can be determined from this non-symmetric dispersion approach. Thus, our study highlights the importance of including myofibre dispersion in cardiac modelling if RBM are used, especially in personalized models.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Effect of myofibre architecture on ventricular pump function by using a neonatal porcine heart model: from DT-MRI to rule-based methods

et al. 2020

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“…The myocardial fibers plays a key role in the electric signal propagation and in the myocardial contraction [47,48,49,50,51]. Due to the difficulty of reconstructing cardiac fibers from medical imaging, a widely used strategy for generating myofiber orientations in EM models relies on the so called Laplace-Dirichlet-Rule-Based-Methods (LDRBMs) [52,53,54,55], recently analysed under a communal mathematical setting [47].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the difficulty of reconstructing cardiac fibers from medical imaging, a widely used strategy for generating myofiber orientations in EM models relies on the so called Laplace-Dirichlet-Rule-Based-Methods (LDRBMs) [52,53,54,55], recently analysed under a communal mathematical setting [47]. While it is well recognized that myofibers orientation is crucial for the construction of a realistic EM model, their architecture has been explored only in a few works and it is not fully understood [20,31,50,56,57]. Another crucial issue for the reconstruction of a suitable cardiac fiber architecture consists in considering the myofibers dispersion around a predominant direction [31,58,59,60].…”

Section: Introductionmentioning

confidence: 99%

3D-0D closed-loop model for the simulation of cardiac biventricular electromechanics

Piersanti,

Regazzoni,

Salvador

et al. 2021

Preprint

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Two crucial factors for accurate numerical simulations of cardiac electromechanics, which are also essential to reproduce the synchronous activity of the heart, are: i) accounting for the interaction between the heart and the circulatory system that determines pressures and volumes loads in the heart chambers; ii) reconstructing the muscular fiber architecture that drives the electrophysiology signal and the myocardium contraction. In this work, we present a 3D biventricular electromechanical model coupled with a 0D closed-loop model of the whole cardiovascular system that addresses the two former crucial factors. With this aim, we introduce a boundary condition for the mechanical problem that accounts for the neglected part of the domain located on top of the biventricular basal plane and that is consistent with the principles of momentum and energy conservation. We also discuss in detail the coupling conditions that stand behind the 3D and the 0D models. We perform electromechanical simulations in physiological conditions using the 3D-0D model and we show that our results match the experimental data of relevant mechanical biomarkers available in literature. Furthermore, we investigate different arrangements in cross-fibers active contraction. We prove that an active tension along the sheet direction counteracts the myofiber contraction, while the one along the sheetnormal direction enhances the cardiac work. Finally, several myofiber architectures are analysed. We show that a different fiber field in the septal area and in the transmural wall effect the pumping functionality of the left ventricle.

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“…Aggregations of myofibers, namely the results of cardiomyocytes orientation, determine how the electric signal propagates within the muscle [1,2,3]. Moreover, also the muscle mechanical contraction, which is triggered by the propagation of the electric signal thorough the tissue, strongly depends on the fibers orientation [4,5,6,7,8]. This motivates the need to accurately include fiber orientations in order to obtain physically meaningful results [9,10].…”

Section: Introductionmentioning

confidence: 99%

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

Piersanti,

Africa,

Fedele

et al. 2021

Preprint

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Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used strategy to include cardiac fibers in computational models. A particular class of such methods is known as Laplace-Dirichlet-Rule-Based-Methods (LDRBMs) since they rely on the solution of Laplace problems. In this work we provide a unified framework, based on LDRBMs, for generating full heart muscle fibers. First, we review existing ventricular LDRBMs providing a communal mathematical description and introducing also some modeling improvements with respect to the existing literature. We then carry out a systematic comparison of LDRBMs based on meaningful biomarkers produced by numerical EP simulations. Next we propose, for the first time, a LDRBM to be used for generating atrial fibers. The new method, tested both on idealized and realistic atrial models, can be applied to any arbitrary geometries. Finally, we present numerical results obtained in a realistic whole heart where fibers are included for all the four chambers using the discussed LDRBMs.

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Influence of fiber connectivity in simulations of cardiac biomechanics

Abstract: Cardiac electromechanical simulations of the heart with fibers extracted from experimental data produce functional scores closer to healthy ranges than rule-based models disregarding architecture connectivity.

Cited by 12 publications

References 26 publications

Effect of myofibre architecture on ventricular pump function by using a neonatal porcine heart model: from DT-MRI to rule-based methods

Effect of myofibre architecture on ventricular pump function by using a neonatal porcine heart model: from DT-MRI to rule-based methods

3D-0D closed-loop model for the simulation of cardiac biventricular electromechanics

Modeling cardiac muscle fibers in ventricular and atrial electrophysiology simulations

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