Influence of ferulic acid on γ-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes

Srinivasan, M.; Sudheer, Adluri Ram; Pillai, Kamala; Kumar, Pankaj; Sudhakaran, P. R.; Menon, Venugopal P.

doi:10.1016/j.tox.2006.09.004

Cited by 112 publications

(66 citation statements)

References 31 publications

(30 reference statements)

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“…Ionizing radiation is known to induce oxidative stress through the generation of ROS resulting in imbalance of the prooxidant and antioxidant activities, ultimately resulting in cell death (Srinivasan et al, 2006). Numerous attempts have been made to investigate different means for controlling and protection from radiation hazards using chemical, physical and biological means.…”

Section: Resultsmentioning

confidence: 99%

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

Abdelhalim¹,

Moussa²

2013

Afr. J. Pharm. Pharmacol.

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This study aimed to address the different gamma radiations doses effect on the liver and kidney function of rats: in vivo. A total of 60 healthy male Wistar-Kyoto rats were whole body gamma irradiated with Co 60 source with 0.883 cG/sec dose rate at the beginning of the experiment. The rats were randomly divided into 4 gamma-irradiation groups (25, 50, 75 and 100 Gy) The serum levels of activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT), UREA, creatinine (CREA) and uric acid (UAC) were measured using automated biochemical analyzer. The ALT, GGT, ALP values significantly decreased with the different gamma radiation doses compared with the control. The AST and UREA values significantly decreased after irradiation with 25 and 50 Gy gamma radiation doses compared with the control while it significantly increased with 75 and 100 Gy gamma radiation doses. The levels of CREA values decreased with no significant manner after the irradiation with gamma radiation doses compared with the control. The levels of UAC values significantly increased with 50, 75 and 100 Gy gamma radiation doses. The serum ALT and AST levels are common markers for hepatic toxicity: A lower amount of ALP indicates liver problems. The decreased CREA and the increased UAC levels might indicate development of nephritis and renal dysfunction. The excess UAC might be converted to crystals depositing in the tiny tubes of the kidney and causing acute kidney damage. It is proposed that oxidative stress is linked to the organ damage following exposure to ionizing radiation, and after the onset of oxidative stress, antioxidant treatment should be applied to delay or prevent the progression of damage.

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Section: Resultsmentioning

confidence: 99%

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

Abdelhalim¹,

Moussa²

2013

Afr. J. Pharm. Pharmacol.

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“…Thus, FA may be included among potentially radioprotective molecules (Kanski et al, 2002;Graf, 1992). Srinivasan et al (2006) evaluated the protective effects of FA in hepatocytes isolated from the liver of rats exposed to gamma radiation. Pretreatment of cells with 1, 5 and 10 mg FA/mL significantly decreased DNA damage, the generation of ROS and increased levels of antioxidant enzymes, suggesting that FA has potential for use in radiotherapy as a radioprotective agent.…”

Section: Radioprotective Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

148

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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“…39 Ferulic acid also has a hepatoprotective effect against toxicity induced in vivo by carbon tetrachloride, as reported by Srinivasan et al,. 40 Treatment with the acid significantly decreased the index of lipid peroxidation in the liver and significantly increased the activities of superoxide dismutase, catalase and glutathione peroxidase. 41 Coumaric and ferulic acids also imparted protection to the antioxidant enzyme SOD, CAT, GPx and GR from paracetamol-induced oxidative damage, which has been measured in terms of enzyme activity.…”

Section: Discussionmentioning

confidence: 92%

“…42 It has been proposed that hydroxyl and hydroperoxyl radicals initiate H + abstraction from a free phenolic substrate to form phenoxyl radical that can rearrange to quinonemethide radical intermediate, 43 which is excreted via bile. Srinivasan et al, 40 have also been reported phenolic acids as a natural protector against carbon tetrachloride induced toxicity.…”

Section: Discussionmentioning

confidence: 98%

Isolation, Structure Elucidation of Ferulic and Coumaric acids from Fortunella japonica Swingle leaves and their Structure Antioxidant activity relationship

El-gizawy

Hussein

2016

FRA

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Influence of ferulic acid on γ-radiation induced DNA damage, lipid peroxidation and antioxidant status in primary culture of isolated rat hepatocytes

Cited by 112 publications

References 31 publications

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

The biochemical changes in rats blood serum levels exposed to different gamma radiation doses

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Isolation, Structure Elucidation of Ferulic and Coumaric acids from Fortunella japonica Swingle leaves and their Structure Antioxidant activity relationship

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