Influence of FecGE mutation on the reproductive variables of Pelibuey ewes in the anestrus period

Muñoz-García, Canuto; Vaquera-Huerta, Humberto; Gallegos‐Sánchez, Jaime; Becerril-Pérez, Carlos Miguel; Tarango-Arámbula, Luis A.; Bravo-Vinaja, Ángel; Cortez‐Romero, César

doi:10.1007/s11250-021-02755-7

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Respecto a la influencia del control genético en variables reproductivas por los genes de la fecundidad, Muñoz- García et al (2021) reportaron un efecto significativo en tasa de ovulación y tasa de prolificidad, pero no en las variables de manifestación del estro, retorno al estro, porcentajes de gestación y parición, en un grupo de ovejas Pelibuey portadoras de la variante mutada Embrapa (GG) con respecto al grupo silvestre (AA) y grupo sin gen (sG). Resultados similares se encontraron para la tasa ovulatoria con el grupo mutado o Embrapa (GG) en ovejas Santa Inés (Silva et al, 2011).…”

Section: Discussionunclassified

“…Este gen interviene en la proliferación y organización de las células de la teca que rodean al folículo (Strauss y Williams, 2019), participa en el crecimiento y desarrollo folicular en todas las etapas de la foliculogénesis, promueve la proliferación y diferenciación de las células de la granulosa (Juengel et al, 2013). Además, este gen tiene un efecto relevante en la tasa de ovulación y prolificidad (Silva et al, 2011;Muñoz-García et al, 2021), en el cual se han identificado cinco variantes genéticas o mutaciones (dominante o mutado, heterocigoto y recesivo o silvestre) en algunas razas de lana: alta fertilidad (Hanrahan et al, 2004), Thoka islandesa (Nicol et al, 2009), Vecaria (Souza et al, 2014) y Finnsheep (Våge et al, 2013;Mullen y Hanrahan 2014) y en razas de pelo: Embrapa o Santa Inés (Silva et al, 2011). Por lo tanto, el uso de la presincronización del estro en presencia del gen GDF9, podría mejorar la respuesta en variables reproductivas.…”

Section: Introductionunclassified

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Influencia De La Presincronización Del Estro en Variables Reproductivas De Ovejas De La Raza Katahdin Portadoras Del Gen Gdf9

Hernández-Rubio

Navarro-Maldonado

Muñoz

et al. 2023

Trop Subtrop Agroecosyst

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Background: Genetic improvement in the sheep species focuses on increasing the number of offspring per sheep. Heritable characteristics such as ovulation rate, fertility, and prolificacy are desirable. Objective: To evaluate the influence of estrus pre-synchronization with PGF2α on the manifestation of estrus, onset and return to estrus (1st and 2nd), pregnancy, lambing, prolificacy, and fertility in Katahdin ewes carrying exon 2 of the gene Factor Growth and Differentiation 9 (GDF9). Methodology: Seventy-two ewes were randomized into four treatments (T): T1 (n = 18), ewes without GDF9 gene and without estrus pre-synchronization; T2 (n = 17), ewes without GDF9 gene and with estrus pre-synchronization; T3 (n = 19) ewes with the GDF9 gene and without estrus pre-synchronization, and T4 (n = 18), ewes with the GDF9 gene and with estrus pre-synchronization. Results: The presence of estrus, the onset of estrus, and returns to estrus, pregnancy, and lambing percentages were not different between treatments (p>0.05). The average pregnancy and lambing in both cases were 86.2% and the average general prolificacy was 1.4 lambs per ewe for all four treatments. There were also no significant differences for the prolificacy or fertility rate (p>0.05). Implications: The present study contributes to the understanding of the use of presynchronization with PGF2α and the effect of the presence of exon 2 of the GDF9 gene on reproductive variables. Conclusions: The presynchronization of estrus with PGF2α and the presence of exon 2 of the GDF9 gene in ewes of the Katahdin breed did not have a significant effect on the reproductive variables evaluated.

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Section: Discussionunclassified

Section: Introductionunclassified

Influencia De La Presincronización Del Estro en Variables Reproductivas De Ovejas De La Raza Katahdin Portadoras Del Gen Gdf9

Hernández-Rubio

Navarro-Maldonado

Muñoz

et al. 2023

Trop Subtrop Agroecosyst

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“…Remarkably, the carriers of the G allele (wild type) were in the same branch of the phylogenetic tree with Sudanese Dubasi, Shugor, and Watish sheep breeds, which had the lowest frequencies of G1 mutant genotypes (Abdelgadir et al, 2021). Also, there were other sheep breeds in which the G1 mutation was not identified, such as Brazilian Santa Inês sheep (Silva et al, 2011) and Norwegian white sheep (Våge et al, 2013) (Muñoz-García et al, 2021Bodensteiner et al, 1999), whereas the carriers of the A allele (mutant type) are on a close branch with the carriers of this mutation in Turkish sheep breeds (Kirikçi et al, 2021). Egyptian sheep breeds, in which the G1 mutation was also not found (Saleh, 2020), are on a branch of the phylogenetic tree separate from all other sheep breeds.…”

Section: Sequencing Of Gdf9 and Bmp15 Genesmentioning

confidence: 91%

Detection of genetic variations in the GDF9 and BMP15 genes in Kazakh meat–wool sheep

Amandykova,

Orazymbetova,

Kapassuly

et al. 2023

Arch. Anim. Breed.

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Abstract. Kazakh meat–wool sheep are of great interest because of the intrabreed multifetal type's high productivity of 140 %–160 %. Genes encoding growth differentiation factor-9 (GDF9) and bone morphogenetic protein 15 (BMP15) are promising candidates for studying sheep productivity, as they affect fertility in mammals, including sheep. Thus, the purpose of this study was to assess the fertility of the Kazakh meat–wool sheep breed based on GDF9 and BMP15 candidate genes of fecundity for the selection of animals with valuable genotypes. We selected 300 heads of the Kazakh meat–wool sheep breed from two populations for PCR-RFLP (polymerase chain reaction–restriction fragment length polymorphism) analysis, 15 of which were subsequently used for sequencing of exon regions of the GDF9 and BMP15 genes. The sheep populations were tested for G1 and G8 mutations of the GDF9 gene and B2 and B4 mutations of the BMP15 gene. The PCR-RFLP analysis revealed that 59 (19.7 %) of the 300 Kazakh meat–wool breed sheep were heterozygous carriers of the G1 mutation (genotype AG) of the GDF9 gene, and sequencing analysis supported these results. The comparative phylogenetic analysis showed a clear separation of Kazakh meat–wool sheep wild types and carriers of the G1 mutation. This mutation was reported to have a relationship with the animals' litter size in other sheep breeds. For this reason, similar relationships should be investigated in Kazakh meat–wool sheep. However, G8, B2, and B4 mutations were not detected among the studied animal populations, showing that these mutations are not characteristic of the Kazakh meat–wool sheep breed.

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“…For the FecG E (Embrapa) variant mentioned above, homozygous ewes carrying the FecG E allele show increased ovulation rate (82%) and prolificacy (58%; Silva et al, 2010). In Pelibuey ewes, Muñoz-García et al (2021) agreed that the FecG E gene mutation in homozygous ewes increased ovulation rate, prolificacy rate and fecundity.…”

Section: Introductionmentioning

confidence: 96%

Fec, CA5A and CLSTN2 genes and their function during sheep ovulation: a review.

Delgado-Tiburcio

Cortez‐Romero

Martínez

et al. 2023

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Objective: To describe the function of Fec, CA5A and CLSTN2 genes during ovulation in ewes. Design/methodology/approach: A search and analysis of scientific information related to Fec, CA5A and CLSTN2 genes in sheep was performed. Results: Fec, CA5A and CLSTN2 genes are involved at the ovarian level; ewes carrying the first gene were found to have increased ovulation rate, folliculogenesis and granulosa cell differentiation. CA5A stimulates an increased follicular rate and plays an important role in pre-implantation. While CLSTN2 has activity in ovarian development and growth; it also has the ability to interact with other genes involved in follicular maturation, granulosa cell differentiation and development of the ovarian follicle. Limitations on study/implications: Ewes carrying these genes increase the prolificacy rate in the flock. Findings/conclusions: The expression of these genes acts synergistically in the ovulatory process, enhancing the ovulatory response by contributing to endocrine, paracrine and molecular synchronisation, so that the maturation of the oocyte occurs, leading to ovulation.

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Influence of FecGE mutation on the reproductive variables of Pelibuey ewes in the anestrus period

Cited by 7 publications

References 30 publications

Influencia De La Presincronización Del Estro en Variables Reproductivas De Ovejas De La Raza Katahdin Portadoras Del Gen Gdf9

Influencia De La Presincronización Del Estro en Variables Reproductivas De Ovejas De La Raza Katahdin Portadoras Del Gen Gdf9

Detection of genetic variations in the GDF9 and BMP15 genes in Kazakh meat–wool sheep

Fec, CA5A and CLSTN2 genes and their function during sheep ovulation: a review.

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