This article discusses the fundamental basis of high strength Al alloy design and describes the role of alloying elements, mechanical processing parameters and heat treatments toward the evolution of microstructure that controls the desired properties i.e. strength, fracture toughness, stress corrosion cracking (SCC) resistance, fatigue crack initiation and propagation resistance, and weldability in 7xxx series Al alloys. The beneficial effects of suitable micro/trace alloying elements, and deleterious effects of certain impurity elements on a variety of properties are further discussed within the present context.