Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy

Şenol, Vesile; Soyuer, Ferhan; Arman, Fehim; Öztürk, Ahmet

doi:10.1016/j.yebeh.2006.08.006

Cited by 82 publications

(69 citation statements)

References 28 publications

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“…We observed that only depression and sleep quality were independently related to fatigue. According to several authors, in patients both with and without epilepsy, fatigue may be associated with depression 3,[5][6][7] and is related to lower quality of life in some domains 3,7 . In the present study, we did not observe any significant relationships between fatigue, frequency of seizures and number of epileptic drugs, in contrast to the study by Hernandez-Ronquillo et al 1 , but in agreement with the report by Hamelin, Kahane and Vercueil 7 .…”

Section: Discussionmentioning

confidence: 99%

Fatigue in patients with epilepsy and its association with depression and sleep quality

Neves

Gomes²

2013

Arq. Neuro-Psiquiatr.

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OBJECTIVE: It was to evaluate the relationships between fatigue and excessive daytime sleepiness, sleep quality, depression and anxiety. METHODS: This was a cross-sectional study on 98 unselected adult patients with epilepsy (PWE) at a tertiary center. It used clinical-sociodemographic characteristics, fatigue measured by the SF-36 vitality subscale (VsSF-36) and the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index and Beck Depression and Anxiety Inventories. RESULTS: We observed that our patients presented vitality or fatigue similar to drivers with chronic headaches evaluated in the same city. Fatigue was related to depression, anxiety and sleep quality, but not to daytime sleepiness. A multiple linear regression analysis was conducted and we observed that fatigue was independently correlated with depression and quality of sleep. However, no significant difference was observed regarding seizure frequency or number of antiepileptic drugs. CONCLUSION: Fatigue needs to be studied more in PWE, and its risk factors need to be controlled, along with sleep quality and psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Fatigue in patients with epilepsy and its association with depression and sleep quality

Neves

Gomes²

2013

Arq. Neuro-Psiquiatr.

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“…These findings include mild executive function deficits [20], and an increased prevalence of depression [29], anxiety [15], substance abuse [29] and social phobia [23]. Research from other neurological disorders, including Parkinson's disease [5], epilepsy [21], and stroke [11] has consistently demonstrated that non-motor symptoms, and in particular alterations of mood, are primary determinants of patient's self-reported QOL. Dystonia seems to be in line with these other neurological disorders.…”

Section: Discussionmentioning

confidence: 99%

Mood and energy determinants of quality of life in dystonia

et al. 2009

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Prior research has demonstrated that dystonia patients may have reductions in numerous measures of quality of life (QOL) when compared to healthy age-matched controls. However, the determinants of QOL in this patient population have not been fully specified. To address this issue, we administered the Medical Outcomes Study Short Form 36 (SF-36) questionnaire along with the Visual Analogue Mood Scale (VAMS), the Beck Depression Inventory (BDI), the Unified Dystonia Rating Scale (UDRS), and the State and Trait Anxiety Index (STAI) to 73 patients diagnosed with primary dystonia. Dystonia patients demonstrated lower QOL on all subscales of the SF-36 compared to normative healthy age-matched data. While the UDRS, a predominantly motor scale, was not significantly correlated with QOL (r = -0.19, P = 0.11), the BDI (r = -0.79, P < 0.0001), the STAI (r = -0.63, P < 0.0001) and multiple subscales of the VAMS revealed significant correlations. The tired subscale was the item most strongly correlated with overall QOL (r = -0.52, P < 0.0001), and particularly QOL related to physical function. The association of tiredness with QOL remained significant even when adjusting for the BDI and STAI scores (P < 0.0001). This study highlights the importance of mood and energy in QOL among a cohort of patients with dystonia. Further studies will be needed to determine the effect of treatment on these associations and whether disturbances in energy are related to sleep disturbances or to primary fatigue issues.

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“…A growing literature is addressing the contribution of psychiatric status (particularly mood, anxiety, depression) to the perceived QoL in patients with epilepsy [18,29,31,33,35,38,47,53,56,68]. Epilepsy carries a risk of unpredictable alteration and loss of consciousness and a complex pattern of wider consequences.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Alterations in Consciousness on Quality of Life (QoL) in Epilepsy: Searching for Evidence

Charidimou

Selai

2011

Behavioural Neurology

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Abstract. The impact of epilepsy on Quality of Life (QoL) is well-documented. The ability of epileptic seizures to alter the conscious states of patients is also well established. Although there is much research on the QoL of people with epilepsy, few researchers have looked specifically at the effect of sudden, unanticipated alterations of consciousness on QoL. This lack of systematic studies of consciousness alterations and QoL in epilepsy limits our ability to shed light on this interrelation. In this article, with these limitations in mind, we focus on studies of newer AEDs. We review the evidence as to whether a significant reduction (typically more than 50%) in seizures that induce alterations of consciousness, as a result of switching to one of the newer AEDs, leads to improvements in QoL. We draw on this literature to speculate on the relationship between ictal consciousness alterations and poor QoL in epilepsy, to identify contributory and confounding factors and to highlight implications for future research. We suggest that an understanding of how factors associated with consciousness impairment affect QoL could help the treatment and management of these patients.

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Influence of fatigue, depression, and demographic, socioeconomic, and clinical variables on quality of life of patients with epilepsy

Cited by 82 publications

References 28 publications

Fatigue in patients with epilepsy and its association with depression and sleep quality

Fatigue in patients with epilepsy and its association with depression and sleep quality

Mood and energy determinants of quality of life in dystonia

The Effect of Alterations in Consciousness on Quality of Life (QoL) in Epilepsy: Searching for Evidence

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