Influence of extracellular cues of hydrogel biomaterials on stem cell fate

Barnett, Haley; Shevchuk, Mariya; Peppas, Nicholas A.; Caldorera‐Moore, Mary

doi:10.1080/09205063.2022.2054398

Cited by 6 publications

(5 citation statements)

References 140 publications

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“…29 Scaffolds for tissue engineering are designed to mimic the native extracellular matrix, which provides physiochemical cues for cell growth and differentiation in vivo , and must therefore be able to promote cell adhesion, proliferation, and differentiation. 30 These results demonstrate that the developed scaffolds are capable of promoting pre-osteoblast growth and proliferation, showing promise for their use as substrates for bone tissue formation.…”

Section: Resultsmentioning

confidence: 75%

Two-phase matrices for the controlled release of therapeutic proteins

David,

Mohanty,

Peppas

2023

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 75%

Two-phase matrices for the controlled release of therapeutic proteins

David,

Mohanty,

Peppas

2023

J. Mater. Chem. B

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“…Hydrogels are increasingly tailored to modulate cellular behaviors and facilitate the regeneration of specific tissues. This customization is achieved by incorporating bioactive molecules such as bioligands [29], growth factors [42,54], and bioactive peptides [49,55], which trigger specific cellular responses conducive to processes like osteogenesis, angiogenesis [8], and cell differentiation [35,56,57]. Such strategic incorporations are designed to meet the regenerative requirements of targeted tissues.…”

Section: Trends In Hydrogel Research For Regenerative Medicinementioning

confidence: 99%

Advancements and Challenges in Hydrogel Engineering for Regenerative Medicine

Omidian,

Chowdhury,

Wilson

2024

Gels

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This manuscript covers the latest advancements and persisting challenges in the domain of tissue engineering, with a focus on the development and engineering of hydrogel scaffolds. It highlights the critical role of these scaffolds in emulating the native tissue environment, thereby providing a supportive matrix for cell growth, tissue integration, and reducing adverse reactions. Despite significant progress, this manuscript emphasizes the ongoing struggle to achieve an optimal balance between biocompatibility, biodegradability, and mechanical stability, crucial for clinical success. It also explores the integration of cutting-edge technologies like 3D bioprinting and biofabrication in constructing complex tissue structures, alongside innovative materials and techniques aimed at enhancing tissue growth and functionality. Through a detailed examination of these efforts, the manuscript sheds light on the potential of hydrogels in advancing regenerative medicine and the necessity for multidisciplinary collaboration to navigate the challenges ahead.

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“… 97 , 102 , 107 , 783 , 784 Precise control over stem cell differentiation is vital for stem cell therapy, yet the regulatory capabilities of existing hydrogel systems in this regard are inadequate. 785 , 786 Moreover, the accurate conveyance of therapeutic agents—including cells, small molecule drugs, and bioactive drugs—to the target site, while sparing adjacent healthy tissues, is crucial for therapeutic success. 787 – 789 This necessitates the formulation of more precise and targeted therapeutic approaches to improve treatment accuracy and efficiency.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Lu,

Ruan,

Huang

et al. 2024

Sig Transduct Target Ther

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The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

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Influence of extracellular cues of hydrogel biomaterials on stem cell fate

Cited by 6 publications

References 140 publications

Two-phase matrices for the controlled release of therapeutic proteins

Two-phase matrices for the controlled release of therapeutic proteins

Advancements and Challenges in Hydrogel Engineering for Regenerative Medicine

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

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