Influence of Exposure Rate on Lung Cancer Induction in Rats Exposed to Radon Progeny

Monchaux, G.; Morlier, J.P.; Altmeyer, Sandrine; Debroche, M.; Morin, M.

doi:10.2307/3580132

Cited by 28 publications

(18 citation statements)

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“…However, at 360 mJW hWm -3 (100 WLM), a greater response is observed at 3.15 mJ W m -3 (150 WL), than that observed at the same time with the higher dose rate of 21 mJWm -3 (1,000 WL) or lower rate of 0.31 mJWm -3 (15 WL). This phenomenon is also observed for the induction of tumours in rats [13]. For binucleated cells, an increase is observed as a function of the dose for cumulative exposures up to 3.6 JWh W m -3 (1,000 WLM).…”

Section: Animal Studiesmentioning

confidence: 53%

“…These results also indicate that the risk of tumour induction in the rat is a maximum for cumulative exposures going from 0.09 mJ W hWm -3 (25 WLM) to 720 mJ W hWm -3 (200 WLM), and a PAEC going from 1.05 mJW m -3 (50 WL) to 3.15 mJW m -3 (150 WL). The results suggest that the induction of lung cancer results from a complex interaction between the cumulative exposure and the dose rate, with an optimum of tumour induction for an optimal combination of cumulative exposure and dose rate [13].…”

Section: Animal Studiesmentioning

confidence: 99%

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Evaluation of the Risk of Exposure to Radon

Monchaux

2001

Indoor Built Environ

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The aim of this project was to assess the risk due to inhalation of radon and its decay products using a horizontal approach across a large-scale research programme. The central objective was the assessment of human risk, a task that required a combination of several programmes and involved a multidisciplinary approach. Five main topics were addressed: radioactive aerosol studies, modelling, human studies, animal studies and retrospective assessment of radon exposure. The five studies were distributed between working groups. The rationale of this project was to pool the expertise from laboratories working in different fields of radiation protection. This paper summarises the main achievements made through this multidisciplinary research programme and the synergies that occurred between the different groups.

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Section: Animal Studiesmentioning

confidence: 53%

Section: Animal Studiesmentioning

confidence: 99%

Evaluation of the Risk of Exposure to Radon

Monchaux

2001

Indoor Built Environ

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“…On peut en outre rappeler ici quelques données expérimentales mettant en évidence l'extrême complexité de la relation dose-effet. Chez le rat de laboratoire très sensible à l'effet cancérogène du radon pour des expositions cumulées à fort débit, une relation complexe lie l'efficacité du radon à la dose et au débit (Monchaux et al, 1999 ;Monchaux, 2004). Aux doses cumulées les plus faibles (équivalentes à moins de 100 mSv en dose efficace chez l'homme) seuls les forts débits (liés aux concentrations de plusieurs milliers de Bq/m 3 de radon dans l'air inhalé) sont associés au cancer.…”

Section: Discussionunclassified

La controverse sur les effets des faibles doses de rayonnements ionisants et la relation linéaire sans seuil

et al. 2007

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RÉSUMÉSi la publication defence against IR involves the cell microenvironment and the immunologic system. The defence mechanisms against low doses are different and comparatively more effective than for high doses. Cell death is predominant against low doses. DNA repairing is activated against high doses, in order to preserve tissue functions. These mechanisms provide for multicellular organisms an effective and low cost defence system. The differences between low and high doses defence mechanisms are obvious for alpha emitters which show several greys threshold effects. These differences result in an impairment of epidemiological studies which, for statistical power purpose, amalgamate high and low doses exposure data, since it would imply that cancer IR induction and defence mechanisms are similar in both cases. Low IR dose risk estimates should rely on specific epidemiological studies restricted to low dose exposures and taking precisely into account potential confounding factors. The preliminary synthesis of cohort studies for which low dose data (< 100 mSv) were available show no significant risk excess, neither for solid cancer nor for leukemias.

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“…There have been various in vitro and in vivo animal studies on rats and dogs exposed to radon, small particles and smoking to investigate the cancer risks associated with such exposures (Monchaux et al, 1994(Monchaux et al, , 1999Hofmann et al, 2006). If biological samples are still available and appropriately stored from such studies, they would offer one possibility to develop and validate biomarkers before testing their applicability in human miner cohorts.…”

Section: Biological Issuesmentioning

confidence: 99%

DoReMi workshop on multidisciplinary approaches to evaluating cancer risks associated with low-dose internal contamination

et al. 2012

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A workshop dedicated to cancer risks associated with low-dose internal contamination was organised in March 2011, in Paris, in the framework of the DoReMi (Low Dose Research towards Multidisciplinary Integration) EuropeanNetwork of Excellence. The aim was to identify the best epidemiological studies that provide an opportunity to develop a multidisciplinary approach to improve the evaluation of the cancer risk associated with internal contamination. This workshop provided an opportunity for in-depth discussions between researchers working in different fields including (but not limited to) epidemiology, dosimetry, biology and toxicology. Discussions confirmed the importance of research on the health effects of internal contamination. Several existing epidemiological studies provide a real possibility to improve the quantification of cancer risk associated with internal emitters. Areas for future multidisciplinary collaborations were identified, that should allow feasibility studies to be carried out in the near future. The goal of this paper is to present an overview of the presentations and discussions that took place during this workshop.Keywords: Cancer / contamination / internal / epidemiology / dosimetry / radiobiology / toxicity / radiological RÉSUMÉ Approches multidisciplinaires pour l'évaluation du risque de cancer associé aux contaminations internes aux faibles doses : synthèse du séminaire scientifique organisé dans le cadre du projet européen DoReMi. Context Current issues for research in radiation protectionIonising radiation is used for many beneficial purposes in medicine and industry. However, it is recognised that there are health risks associated with exposure to ionising radiation. There is clear evidence that radiation increases the risk of cancer in irradiated populations such as the Japanese atomic bombing survivors when doses are in excess of around 100 mSv. Direct evidence of risk below these levels is ambiguous and extrapolation from risk information available from the higher dose studies is used to estimate low dose risk. However, the exposures of concern for human populations are in the vast majority of cases in this low-dose region (<100 mSv) and generally at low dose rates (<1 mSv min -1 ). It is therefore the health risks in this low dose/dose-rate region that radiation protection standards and policy address. The risk estimates for cancer used in radiation protection derive mainly from epidemiological studies of the Japanese A-bomb survivors (UNSCEAR, 2008). This population was exposed at a high dose rate to external gamma and neutron irradiation, with a wide range of individual doses (from 0 to 4 Sv, with a mean at about 200 mSv). Many situations of radiation exposure, however, concern internal contamination with radionuclides; not least is the exposure of the public to background radiation, the major source of which is inhaled radon gas. Internal contamination is also encountered in medical diagnostics and in occupational settings. A wide range of radionuclides are potent...

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Influence of Exposure Rate on Lung Cancer Induction in Rats Exposed to Radon Progeny

Cited by 28 publications

References 11 publications

Evaluation of the Risk of Exposure to Radon

Evaluation of the Risk of Exposure to Radon

La controverse sur les effets des faibles doses de rayonnements ionisants et la relation linéaire sans seuil

DoReMi workshop on multidisciplinary approaches to evaluating cancer risks associated with low-dose internal contamination

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