Influence of experimental hyperthyroidism on insulin action in growing sheep

Weekes, T. E. C.

doi:10.1016/0026-0495(92)90266-d

Cited by 15 publications

(9 citation statements)

References 36 publications

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“…In the glucose clamp procedure, blood GTR increased with increased insulin infusion rates in a dose-dependent manner as reported previously [15,33,34]. This reflected enhanced glucose utilization in insulin dependent tissues such as skeletal muscle and adipose tissue [35].…”

Section: Discussionsupporting

confidence: 63%

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Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Sano

Fujita

2006

Reprod. Nutr. Dev.

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-An experiment combining a hyperinsulinemic euglycemic clamp procedure of four sequential 2-h periods and an isotope dilution method of [U-13 C]glucose determined the effect of supplemental calcium propionate on blood glucose metabolism during insulin and glucose infusions in adult sheep. They were fed lucerne hay cubes and commercial concentrate with and without supplementary calcium propionate (Prop and Cont diets, respectively) in a crossover design for each 21-day period. At the preinfusion period, blood glucose turnover rate (GTR) was greater (P < 0.05) for the Prop diet than for the Cont diet. Blood GTR, endogenous glucose production rate (EGPR) and the ratio of EGPR to blood GTR were greater (P < 0.01, P < 0.05 and P < 0.05, respectively) for the Prop diet than for the Cont diet. Blood GTR and glucose infusion rate (GIR) increased (P < 0.001) and the ratio of EGPR to blood GTR was reduced (P < 0.01) with increased insulin infusion rates. The maximal GIR tended to be (P < 0.10) greater for the Prop diet than for the Cont diet but plasma insulin concentration at half maximal GIR did not differ between diets. It is suggested that in adult sheep, dietary propionate supplementation enhances insulin action on glucose metabolism, however, changes in measures of tissue responsiveness and sensitivity were not significant. calcium propionate / glucose clamp technique / glucose metabolism / insulin / isotope dilution method / sheep

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Section: Discussionsupporting

confidence: 63%

“…The GIR max and ED 50 were somewhat higher than those reported previously [12,33,34], because the step numbers and rates of insulin infusion and the regression equations differed. However, they were comparable between the Cont and Prop diets.…”

Section: Discussioncontrasting

confidence: 62%

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Sano

Fujita

2006

Reprod. Nutr. Dev.

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“…Similarities in the effects of insulin on whole-body glucose disposal and on proteolysis have already been noted : hypothyroidism impaired the antiproteolytic effect of insulin [22], whereas hyperthyroidism increased this effect [23]. Moreover, insulininduced hypoaminoacidaemia was more significant in the hyperthyroid than in the euthyroid state [14,33].…”

Section: Discussionmentioning

confidence: 70%

Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism

Rochon

Tauveron²,

Dejax

et al. 2002

Clinical Science

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We have examined insulin action on glucose metabolism in six hypothyroid patients before and after regular thyroid hormone treatment, and in six healthy volunteers before and after transient induction of moderate hyperthyroidism. Insulin was infused under euglycaemic and eukalaemic clamps. An appropriate amino acid infusion was used to blunt insulin-induced decreases in amino acid levels. Glucose kinetics were assessed using a primed continuous infusion of [6,6-(2)H(2)]glucose. The results showed that basal plasma insulin and glucose levels (i.e. before infusion) were similar in each case. Despite similar insulin infusion rates, the plateau value of insulin was lower after thyroid treatment in both hypothyroid patients and healthy volunteers. The rate of exogenous glucose needed to maintain plasma glucose at a steady-state level was increased by thyroid hormone in hypothyroid patients (P <0.05), but not in healthy volunteers. Thyroid treatment resulted in a significant increase in basal glucose disposal in both groups (P <0.05). Insulin, in conjunction with glucose and amino acids, significantly stimulated glucose disposal (P <0.05) under all conditions. The incremental increase in glucose disposal after infusion tended to be higher following thyroid hormone treatment, but this was not statistically significant. However, the ratio of the incremental increase in glucose disposal to the increase in plasma insulin was significantly improved after thyroid hormone treatment in hypothyroid patients (P <0.05). It was also increased in healthy volunteers, but not significantly. We conclude that thyroid hormones improve the ability of insulin to stimulate glucose disposal related to insulinaemia. This phenomenon may be highly sensitive, because it was only apparent at low thyroid hormone levels.

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“…Severe hyperthyroidism worsens glycemic control in diabetic patients through several mechanisms, such as an increase of intestinal glucose absorption, insulin degradation, and enhancement of basal hepatic glucose production, a decrease in both insulin secretion and peripheral use of glucose due to insulin resistance [4][5]. Therefore, the presence of diabetes mellitus or even diabetic ketoacidosis should be sought in patients with hyperthyroidism, and vice versa, particularly in young women.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Presentation of Thyrotoxicosis and Diabetic Ketoacidosis Resulted in Sudden Cardiac Arrest

et al. 2007

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Abstract. Although many cases of simultaneous presentation of thyrotoxicosis (thyroid storm) and diabetic ketoacidosis have been reported, it is a clinically unusual situation and remains a diagnostic and management challenge in clinical practice. The diagnosis of diabetic ketoacidosis or thyrotoxicosis may be masked leading to serious complications. We report two patients with simultaneous thyrotoxicosis and diabetic ketoacidosis resulted in sudden cardiac arrest, emphasizing early recognition and prompt treatment when these two disease are presented concomitantly.

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Influence of experimental hyperthyroidism on insulin action in growing sheep

Cited by 15 publications

References 36 publications

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep

Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism

Simultaneous Presentation of Thyrotoxicosis and Diabetic Ketoacidosis Resulted in Sudden Cardiac Arrest

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