Influence of Experimental Conditions on Electronic Tongue Results—Case of Valsartan Minitablets Dissolution

Wesoły, Małgorzata; Kluk, Anna; Sznitowska, Małgorzata; Ciosek, Patrycja; Wróblewski, Wojciech

doi:10.3390/s16091353

Cited by 15 publications

(8 citation statements)

References 33 publications

(37 reference statements)

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“…Drug dissolution tests were also used as a reference method in our studies on modified-release pharmaceutical formulations conducted with the electronic tongue [71,73]. High correlation (R 2 = 0.889) of electronic tongue results with reference dissolution studies was obtained testing minitablets containing valsartan (although it should be emphasized that similar conditions of both experiments were essential for good accordance of the outcomes).…”

Section: Reference Methodsmentioning

confidence: 99%

“…Therefore, we examined various experimental factors, such as temperature, pH, and composition of the medium, in order to determine their influence on electronic tongue dissolution studies of pharmaceutical formulations. Moreover, the performance of the electronic tongues working in various hydrodynamic conditions was compared testing two systems with different architecture of the sensor array (but similar composition of the ion-selective membranes used in the electrodes) [71]. Minitablets containing valsartan were used as model pharmaceutical samples.…”

Section: Experimental Conditions and Measurements Protocolsmentioning

confidence: 99%

“…(A) Dissolution profiles of valsartan minitablets, (B) PCA plot during the release process carried out at 37 • C, and correlation coefficients calculated between the amount of API released during classical dissolution studies conducted at various temperature and distance in PC1-PC2 space. Adapted from[71].…”

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confidence: 99%

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Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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Electronic tongue systems equipped with cross-sensitive potentiometric sensors have been applied to pharmaceutical analysis, due to the possibility of various applications and developing new formulations. Many studies already proved the complementarity between the electronic tongue and classical analysis such as dissolution tests indicated by Pharmacopeias. However, as a new approach to study pharmaceuticals, electronic tongues lack strict testing protocols and specification limits; therefore, their results can be improperly interpreted and inconsistent with the reference studies. Therefore, all aspects of the development, measurement conditions, data analysis, and interpretation of electronic tongue results were discussed in this overview. The critical evaluation of the effectiveness and reliability of constructed devices may be helpful for a better understanding of electronic tongue systems development and for providing strict testing protocols.

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Section: Reference Methodsmentioning

confidence: 99%

Section: Experimental Conditions and Measurements Protocolsmentioning

confidence: 99%

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Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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“…All calculations and data analysis was performed in MatLab (The MathWorks, Inc., Natick, MA, USA) and Origin (Microcal Software, Inc., Northampton, MA, USA) software. Measurements were conducted at 37 °C (Wesoły et al, 2016). The release of CET from the formulations was observed as the difference in sensor signals in time.…”

Section: Methodsmentioning

confidence: 99%

Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles

Amelian

Wasilewska

Wesoły

et al. 2017

Saudi Pharmaceutical Journal

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Orally disintegrating tablets and oral lyophilisates are novel attractive dosage forms that disintegrate or dissolve in the buccal cavity within seconds without necessity of drinking. The major limitation in designing of these dosage forms is unpleasant taste of the drug substance. Cetirizine dihydrochloride is a H-antihistamine substance indicated for the treatment of allergy. It is characterized by extremely bitter taste, therefore in order to deliver cetirizine dihydrochloride using orodispersible formulations, effective taste-masking is required. The aim of this study was to investigate whether microparticles containing cetirizine dihydrochloride could be successfully used to formulate orally disintegrating tablets by direct compression method and oral lyophilisates by freeze-drying process. Taste masking of cetirizine dihydrochloride was achieved by the spray-drying technique using Eudragit E PO as the drug agent carrier. Based on the preliminary studies, optimal compositions of microparticles, tablets and lyophilisates were chosen. Obtained dosage forms were characterized for drug content, disintegration time and mechanical properties. In order to determine whether the microparticles subjected to direct compression and freeze-drying process effectively mask the bitter taste of cetirizine dihydrochloride, the and evaluation was performed. The results showed that designed formulates with microparticles containing cetirizine dihydrochloride were characterized by appropriate mechanical properties, uniformity of weight and thickness, short disintegration time, and the uniform content of the drug substance. Taste-masking assessment performed by three independent methods (e-tongue evaluation, human test panel and the drug release) revealed that microparticles with Eudragit E PO are effective taste - masking carriers of cetirizine dihydrochloride and might be used to formulate orally disintegrating tablets and oral lyophilisates.

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“…The benefits of SODF such as microparticulate or oro-dispersible dosage forms include dose flexibility and titration, ease of ingestion and enhanced patient adherence [ 6 , 7 ]. Efforts have been put into the development of multiparticulate dosage forms such as minitablets and microparticles [ 8 , 9 ]. Microparticles are solid dosage forms in which an active pharmaceutical ingredient (API) is incorporated into a polymeric matrix formed into spherical or irregular shaped particles between 1–1000 μm in size.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

2020

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Cardiovascular diseases such as hypertension and cardiac failure in South African children and adolescents are effectively managed long term, using a combination treatment of captopril and hydrochlorothiazide. The majority of commercially available pharmaceutical products are designed for adult patients and require extemporaneous manipulation, prior to administration to paediatric patients. There is a need to develop an age appropriate microparticulate dosing technology that is easy to swallow, dose and alter doses whilst overcoming the pharmacokinetic challenges of short half-life and biphasic pharmacokinetic disposition exhibited by hydrochlorothiazide and captopril. An emulsion solvent evaporation approach using different combinations of polymers was used to manufacture captopril and hydrochlorothiazide microparticles. Design of experiments was used to develop and analyse experimental data, and identifyoptimum formulation and process conditions for the preparation of the microparticles. Characterisation studies to establish encapsulation efficiency, in vitro release, shape, size and morphology of the microparticles were undertaken. The microparticles produced were in the micrometre size range, with an encapsulation efficiency >75% for both hydrochlorothiazide and captopril. The microparticulate technology is able to offer potential resolution to the half-life mediated dosing frequency of captopril as sustained release of the molecule was observed over a 12-h period. The release of hydrochlorothiazide of >80% suggests an improvement in solubility limited dissolution.

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Influence of Experimental Conditions on Electronic Tongue Results—Case of Valsartan Minitablets Dissolution

Cited by 15 publications

References 33 publications

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles

Formulation and Characterisation of a Combination Captopril and Hydrochlorothiazide Microparticulate Dosage Form

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