Influence of excessive daily sleeping and sleep quality on BDNF and NGF serum levels in adolescents

Silva, João Ferreira; Éckeli, Alan Luiz; Ribeiro, Cecília Cláudia Costa; Batista, Rosângela Fernandes Lucena; Silva, Antônio Augusto Moura da; Alves, Cláudia Maria Coêlho

doi:10.1016/j.sleep.2021.06.024

Cited by 8 publications

(5 citation statements)

References 70 publications

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“…In patients with T2DM, unlike their nondiabetic counterparts, there are a lot of sleep problems potentially contributing to poor sleep quality 6 , and this may be responsible for the reduction of BDNF. The relationship between the duration of sleep and serum BDNF levels may follow a U-shaped pattern, as reported in adolescents 29 . Hence, the linear models applied to our analysis of the data from this study might have masked possible biological interaction.…”

Section: Discussionmentioning

confidence: 73%

Brain-Derived Neurotrophic Factor is Associated with Self-Reported Quality of Sleep in Type 2 Diabetes Patients in Ghana

Agyekum,

Yeboah

2024

Exp Clin Endocrinol Diabetes

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Objective: Sleep disturbances are common in Type 2 diabetes (T2DM) patients and this exacerbates the severity of disease and results in poor quality of life. Brain-derived neurotrophic factor (BDNF) has been reported to mediate the association between T2DM and poor sleep health. We investigated the burden of self-reported poor sleep quality and duration in T2DM and their association with serum BDNF levels. Methods: In a case-control design, the Pittsburgh Sleep Quality Instrument (PSQI) was used to assess self-reported sleep quality and duration in 100 T2DM patients and 80 nondiabetic controls. Sociodemographic data and medical history were collected from case notes and/or using a structured questionnaire. 5 ml of fasting venous blood samples were collected to measure plasma lipid profile and serum BDNF levels. Results: T2DM patients had low levels of BDNF, poor sleep quality (61.9% vs 27.5%, p<0.001), and shorter sleep duration (6.1±2.2 vs 6.9±1.1 hours, p=0.003). T2DM status was associated with doubling the odds of poor sleep quality [OR (95% CI) = 2.06 (1.07 – 6.43), p=0.039] and 1.6 times the odds of short sleep duration [1.63 (1.03 – 3.79), p=0.028]. There was no association between serum BDNF levels and sleep status in multivariable logistic regression analysis. However, there was a negative biological interaction between T2DM and BDNF levels on poor sleep quality, resulting in 0.28 relative excess risk due to the interaction and a 12% attributable proportion due to the interaction. Conclusion: T2DM patients in our study population had a high burden of self-reported poor quality of sleep and shorter sleep duration compared to the nondiabetic controls. T2DM interacts negatively with serum BDNF levels to affect sleep quality.

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Section: Discussionmentioning

confidence: 73%

Brain-Derived Neurotrophic Factor is Associated with Self-Reported Quality of Sleep in Type 2 Diabetes Patients in Ghana

Agyekum,

Yeboah

2024

Exp Clin Endocrinol Diabetes

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“…On the other hand, previously, we have observed a positive correlation between the severity of insomnia and the BDNF protein concentration [ 27 ]. Sleep quality was found to be negatively correlated with BDNF in female Japanese workers; however, no such differences were observed in a study on Brazilian adolescents [ 11 ]. In another study on subjects with obstructive sleep apnea (OSA), higher serum BDNF was associated with increased ESS score [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…A decrease in BDNF expression resulting from polymorphism Val66Met was related to lower sleep intensity, slow-wave sleep duration, and alterations of slow-wave activity (prolonged onset and dissolution) [ 10 ]. Low BDNF was also associated with a reduction in N3 and rapid eye movement stage [ 11 ]. On the other hand, insomnia decreases BDNF levels, while an acute form of sleep deprivation increases them.…”

Section: Introductionmentioning

confidence: 99%

Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease

et al. 2023

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Inflammatory bowel disease (IBD) patients often have sleep and mood disorders. Brain-derived neurotrophic factor (BDNF) and proBDNF were shown to modulate interactions between the central nervous system and the gastrointestinal tract, possibly contributing to psychological issues. Anti-tumor necrosis factor (TNF) therapy in IBD can alter BDNF expression and further affect the brain–gut axis. Eighty IBD patients and 44 healthy controls (HCs) were enrolled and divided into subsets based on disease activity and condition (ulcerative colitis (UC)/Crohn’s disease (CD)). Questionnaires evaluating sleep parameters and depression as well as venous blood were collected. The IBD group had a lower expression of BDNF mRNA, but higher proBDNF and BDNF protein concentration than HCs. The UC group had a higher BDNF protein concentration than the CD. BDNF protein was positively correlated to sleep efficiency in the IBD group. Depression severity was associated positively with BDNF mRNA and negatively with BDNF protein in the remission group. Anti-TNF therapy enhanced BDNF mRNA expression. The BDNF pathway might be disturbed in IBD, linking it to sleep disorders and depression. Systemic inflammation could be the main cause of this disruption. BDNF mRNA is a more reliable parameter than protein due to numerous post-translational modifications.

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“…A relationship between serum BDNF and poor sleep quality was suggested, and previous studies reported a negative correlation between sleep quality index and BDNF levels. 45,46 As far as we know, this study investigated the association between BDNF levels and sleep quality in cSLE patients for the first time. Observation of no significant difference in terms of sleep quality between cSLE patients and control group might be attributed to the lifestyle changes during the COVID-19 pandemic period.…”

Section: Discussionmentioning

confidence: 99%

Depression, anxiety, and sleep quality in childhood onset systemic lupus erythematosus and relationship with brain-derived neurotrophic factor

Baba

Kısaoğlu

Bilginer

et al. 2022

Lupus

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Background The association between brain-derived neurotrophic factor (BDNF) and systemic lupus erythematosus (SLE) is controversial, and no study investigated the clinical associations of BDNF in patients with childhood onset systemic lupus erythematosus (cSLE). In this study, we aimed to investigate the serum levels of BDNF in patients with cSLE and examine whether a relationship of BDNF exists among depression, anxiety, and sleep quality. Methods Thirty patients and age-sex matched healthy controls were included. Depression, anxiety, sleep quality and quality of life were assessed by relevant questionnaires. Disease activity was assessed according to the SLE disease activity index (SLEDAI) and serum BDNF level was measured by the enzyme-linked immunosorbent assay method. Results Serum BDNF level was significantly lower in cSLE patients than healthy controls (21981 vs 29905 pg/mL, p = 0.001) and significantly decreased level was observed in active cSLE (SLEDAI >0), then those with SLEDAI = 0 (17110 vs 26852 pg/mL, p = 0.005). Although the scores of the depression, anxiety, sleep quality and quality of life questionnaires were strongly correlated with each other, no correlation was observed with serum BDNF levels. Conclusions In patients with cSLE, serum level of BDNF was significantly decreased compared to healthy controls. Our results suggest that serum BDNF levels were not associated with the presence of anxiety, depression and poor sleep quality and might be dictated by the pathophysiological process of SLE rather than mood disorders.

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Influence of excessive daily sleeping and sleep quality on BDNF and NGF serum levels in adolescents

Cited by 8 publications

References 70 publications

Brain-Derived Neurotrophic Factor is Associated with Self-Reported Quality of Sleep in Type 2 Diabetes Patients in Ghana

Brain-Derived Neurotrophic Factor is Associated with Self-Reported Quality of Sleep in Type 2 Diabetes Patients in Ghana

Relation between Selected Sleep Parameters, Depression, Anti-Tumor Necrosis Factor Therapy, and the Brain-Derived Neurotrophic Factor Pathway in Inflammatory Bowel Disease

Depression, anxiety, and sleep quality in childhood onset systemic lupus erythematosus and relationship with brain-derived neurotrophic factor

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