Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats

Zanoli, Paola; Zavatti, Manuela; Montanari, C.; Baraldi, Mario

doi:10.1016/j.jep.2009.08.021

Cited by 77 publications

(56 citation statements)

References 31 publications

(31 reference statements)

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“…In another study, acute (500 and 1000 mg/kg) and subacute (500 mg/kg) treatment of EL extracts to sexually sluggish male rats was shown to reduce ejaculation latencies and increase the percentage of mounting and ejaculation [33]. The reduced post-ejaculatory interval was also found with subacute EL administration.…”

Section: Effects Of El On Sexual Behaviour In Animal Studymentioning

confidence: 87%

“…Zanoli, Zavatti [33] have investigated the effect of acute and subacute administration of EL in sexually sluggish and impotent male rats. Ejaculation latencies and post-ejaculatory interval were decreased while the percentage of mounting and ejaculating was increased with EL supplementation in sexually sluggish rats.…”

Section: Discussionmentioning

confidence: 99%

“…Zanoli, Zavatti [33] assessed mounting, intromission and ejaculation latency in copulatory behavior test while partner preference test was used to assess sexual motivation in sexually sluggish and impotent male rats. Ang and Sim [35] measured copulation activities, successful crossover and subsequent mountings in sexually naïve male rats.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Effect of Eurycoma Longifolia on Sexual Behavior in Sexually Dysfunctional Male: A Systematic Review

Jayusman

Mohamed

Thu

et al. 2017

Int J Pharm Pharm Sci

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Objective: This systematic review was conducted to summarize and evaluate the effect of Eurycoma longifolia (EL) on sexual behavior in the sexually dysfunctional male.Methods: Ovid Medline, Wiley Online Library, Scopus, BioMed Central, Hindawi and Google Scholar databases were searched for relevant studies published from 1995 to 2016 and search was limited to relevant studies published in English. Studies assessing aphrodisiac properties of EL on male sexual behavior in sexually dysfunctional animal models or human were included. Results:Among the 155 studies identified in the literature search, a total of 6 eligible articles (5 animal studies and one human study) were selected and reviewed. All studies reported positive aphrodisiac activities and supported the use of the plant as an aphrodisiac. Conclusion:This systematic review highlighted the effect of EL extract as an aphrodisiac agent to improve sexual behavior in the sexually dysfunctional male. Further studies are required to determine the specific mechanisms of action and identification of the bioactive components of EL responsible for its potential efficacy.

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Section: Effects Of El On Sexual Behaviour In Animal Studymentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Eurycoma Longifolia on Sexual Behavior in Sexually Dysfunctional Male: A Systematic Review

Jayusman

Mohamed

Thu

et al. 2017

Int J Pharm Pharm Sci

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“…This was in fact found to be true as the outcomes of recent investigations disclosed its strong steroidogenesis and spermatogenesis in rodents. [28] Elsewhere, its standardized methanol extract reversed the infertility induced by Andrographis paniculata through significant boost in testosterone synthesis both in plasma and testes. The resultant testosterone then stimulated spermatogenesis by binding to Androgen Binding Protein (ABP).…”

Section: Introductionmentioning

confidence: 99%

Eurycoma longifolia Jack (Simarubaceae); Advances in Its Medicinal Potentials

Wizneh¹,

Asmawi²

2014

Phcog J.

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Eurycoma longifolia Jack is a tall slender shrub-tree which is well-reputed among the natives of South East Asia for its potent aphrodisiac effect. Its root extracts have shown important biological activities such as antitumor, antimalarial, antibacterial, anti-diabetic, anti-hypertensive, Osteoprotective, and ergogenic which are mainly attributed to quassinoids. Commercially it is available in the form of drinks (along with other herbs), capsules, or loose powders. Based on available online databases it was realized that in spite of numerous reports on medicinal properties of E. longifolia, a review of recent developments regarding phytopharmacology, safety and toxicology, pharmacokinetics, and clinical applications was lacking. Therefore, this concise yet informative piece of work was prepared by pulling together trustworthy information from all the accessible published and unpublished scientific resources to serve as a reliable source of reference for future investigations.

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“…Known popularly as "Tongkat Ali", the tree from which Longjack root is harvested reaches a height of around 10 meters, is slender and often unbranched, and contains reddish brown petioles. Currently, Longjack products are available as a raw crude powder of the root, a capsule, mixed in proprietary blends, and as an additive mixed with coffee.Studies have provided evidence in support of the claim that a particular compound called eurycomanone, extracted from Longjack root, can increase testosterone levels in rats [102,[115][116][117]. A recent study in humans involved supplementation of 76 of 320 patients suffering from late-onset hypogonadism with a 200 mg serving of a standardized water-soluble extract of Tongkat ali for 1 month [39].…”

mentioning

confidence: 99%

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

Gunnels¹

2014

J Plant Biochem Physiol

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Low circulating testosterone levels can present numerous problems related to the overall health and well-being of individuals, men in particular. This finding is well-documented in the literature and low testosterone appears more prevalent in older men, in particular those who are physically inactive and who present with elevated levels of body fat. Multiple botanical (herbal) products have been claimed to elevate circulating testosterone in men; however, data pertaining to the use of such herbal preparations obtained from human clinical trials are limited. This review examines the research to date pertaining to the use of herbal ingredients with regards to their ability to elevate blood testosterone levels. A collective summary of the findings indicate that certain herbal supplements may actually yield an increase in testosterone (e.g., Longjack root), while most others have little to no evidence in support of their use in human subjects. Additional, well-controlled clinical trials are needed to generate data relative to the use of herbal dietary supplements to increase circulating testosterone. Testosterone is generally measured as either "free" (unbound) or "total" (unbound and chemically bound). Men who have a morning serum testosterone level < 300 ng/dL are considered to be "low" and may be a candidate for testosterone replacement therapy-which has become more common in recent years due to the increased diagnosis of andropause [55]. Insufficient levels of testosterone due to either impaired production or uptake can present serious health consequences due to the wide array of applications of testosterone within the human body. Areas including skeletal muscle health, muscular strength, and overall well-being/vitality seem to be significantly affected by testosterone status. Increasing Circulating Testosterone: Impact of Herbal Dietary SupplementsTrintThe role of testosterone in muscle growth has been investigated extensively in both humans and animals [56][57][58][59][60][61][62]. One study in men concluded that the testosterone-induced increase in muscle volume is due to muscle fiber hypertrophy [63]. A follow-up study conducted a year later noted muscle hypertrophy in men over a period of 20 weeks of treatment with a gonadotropin-releasing hormone agonist and a 125-, 300-, or 600-mg weekly dose of testosterone enanthate. The main findings from this study indicated that testosterone administration was associated with a significant increase in myonuclear number in men receiving the 300-and 600-mg doses.Muscular strength is another important factor that has been shown to be affected by testosterone levels in the body [56,61,62,[64][65][66]. A recent investigation utilized 267 men with stages 2-4 of Chronic Kidney Disease to assess the impact of testosterone level on a variety of variables [64]. This study found that testosterone was significantly and independently associated with handgrip strength, muscle mass, and nutritional status as the disease progressed. Another study explored short-term testoste...

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Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male rats

Cited by 77 publications

References 31 publications

Effect of Eurycoma Longifolia on Sexual Behavior in Sexually Dysfunctional Male: A Systematic Review

Effect of Eurycoma Longifolia on Sexual Behavior in Sexually Dysfunctional Male: A Systematic Review

Eurycoma longifolia Jack (Simarubaceae); Advances in Its Medicinal Potentials

Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements

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