Influence of ethanol on aluminum-induced alterations in oxidative stress of rat thalamic area

Nayak, Prasunpriya; Sharma, Shiv Bhushan; Chowdary, N V S

doi:10.4103/2277-8632.191837

Cited by 1 publication

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, thalamic GSH content was maintained even with exposure to a moderate dose of Et exposure for 4 weeks even without T3 supplementation (Figure 2B) and along with an increase in thalamic GSSG content (Figure 3B). Alterations in GSH content in the thalamic area of experimental animals with low-to-moderate doses of Et exposure were reported earlier (16,17). Additionally, the highest baseline GSH concentration and potentially higher GSH recycle rate in the thalamus of F344 rats have also been reported.…”

Section: Discussionsupporting

confidence: 65%

“…15 The thalamic area is reported to be susceptible to neurodegenerative diseases 16 and oxidative stress. 17 While, the thalamus could maintain the level of lipid peroxidation during normal aging, enhanced lipid peroxidation was reported in response to degenerative threats like aluminum exposure. 18 Oxidative stress can suggestively damage the specific nuclei in the thalamus leading to failure in suppression of distracting information and attention deficit in individuals.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tocotrienol supplementations ameliorate oxidative stress in thalamus of rats exposed to low-to-moderate doses of ethanol

Dasari,

Kaushik Raghavendra,

P. Nayak

2023

Ind. J. Physiol. Allied Sci.

View full text Add to dashboard Cite

Background: Functional deterioration of thalamic structures has been reported in many occasions of ethanol-induced neurodegeneration. Neuroprotective role of Tocotrienol (T3) is well established along with its antioxidant property. Interaction of oral T3 supplementation modalities with the thalamic oxidative stress parameters were studied in low-to-moderate doses of ethanol (Et) exposures. Materials and Methods: Four phase of experiments were carried out with nil (Et-0) and three doses of Et exposures (Et-I, Et-II and Et-III) for 4 weeks. In each phase, 4 groups of Wistar rats were maintained with sham supplementation (NT3), prior supplementation (PT3), simultaneous supplementation (ST3) and total supplementation (TT3) with T3 for 6 weeks. Thalamic levels of reduced glutathione (GSH) and lipid peroxidation (LPO) were estimated. Results: Two-way ANOVA demonstrated that all the thalamic GSH and LPO were significantly influenced by the modalities of T3 supplementation. However, low-to-moderate doses of Et exposures contributed significantly in alterations of only LPO level of thalamus. Conclusion: Out of the tested modalities, best protection in terms of oxidative stress was observed when prior and simultaneous supplementation modalities were combined (TT3).

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%