Influence of Estrogen Plus Testosterone Supplementation on Breast Cancer

Abstract

Although our results have less strength than an initial report linking E + T to breast cancer, we found a modest, albeit nonsignificant, elevation in breast cancer risk associated with E + T use.

Testosterone and risk of breast cancer: appraisal of existing evidence

“…When treated for duration longer than 5 years, no significant associations were observed. This finding casts serious doubts on the outcome of this study and does not support the conclusions made by the authors that an association exits between increased breast cancer risk and T. These findings are also contrary to the conclusion made by several authors (32,(63)(64)(65)(66)(67)(68)(69). Thus, it is possible that these data are a result of confounding recruitment bias similar to that noted in the UK Million Women Study.…”

“…Non-significant associations were found between estrogen plus testosterone treatment and invasive breast cancer utilizing the WHI cohort (65). However, an increased risk for Estratest, a preparation of esterified estrogens and methyltestosterone was noted.…”

Automated and sensitive determination of four anabolic androgenic steroids in urine by online turbulent flow solid-phase extraction coupled with liquid chromatography–tandem mass spectrometry: A novel approach for clinical monitoring and doping control

“…However, long term usage of anabolic steroids can cause many adverse effects such as gynecomastia, elevated blood pressure, liver damage, cardiovascular disease or coronary artery disease. Serum concentrations of AAS are of particular importance and often monitored for diagnosis, treatment or research on the relationship between their concentrations and diseases [8][9][10][11]. Urinary concentrations are also received great attention because of its noninvasive detection [12][13][14].…”

Androgeny u kobiet pomenopauzalnych

“…W opublikowanym badaniu Nurses Health Study wykazano wzrost ryzyka raka piersi u kobiet po menopauzie stosujących terapię estrogenową łączoną z preparatami testosteronu w porównaniu z kobietami stosującymi same estrogeny lub estrogeny z gestagenami [20]. Podobnie w badaniu WHI (Women's Health Initiative) badacze ustalili dodatnią, choć nieistotną statystycznie, korelację między stosowaniem estrogenów i testosteronu a rakiem piersi [21]. Istnieją jednak doniesienia, w których autorzy bardzo jednoznacznie wypowiadają się o bezpieczeństwie terapii androgenami i podkreślają brak związku takiej terapii z ryzykiem rozwoju raka piersi i raka endometrium [20,22].…”