Influence of esophageal variceal bleeding on iron status in chronic hepatitis C patients

Abbas, Omaima M; Khalifa, Khaled A; Makhlouf, Manal Mohamed; Osman, Nahla; Abdel-Razek, Waël; Atta, Asmaa Said

doi:10.1097/meg.0000000000001547

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Shan et al study shows a strong relationship amid serum iron levels and HCV infection. Exposure to hidden viruses is related with fluctuations in levels of ferritin formerly and later to treatment 23 . Even if the ferritin level has risen before treatment; however, later to treatment, levels of ferritin may decline.…”

Section: Discussionmentioning

confidence: 99%

Assessing Responsiveness of Elevated Serum Ferritin for Treatment in Chronic Hepatitis C Infected Patients

Iqbal¹,

Baig²,

Ali³

et al. 2021

PJMHS

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Background: Hepatitis C virus (HCV) infection is a foremost community health issue globally. There is anoptimisticrelationamid iron accumulation in hepatocytes and high serum markers counting transferrin and ferritin. The purpose of this analysis was to examine the responsiveness of the treatment with elevated serum ferritin in patients with hepatitis C infection. Methods: The study included 200 HCV-infected patients from the department of Medicine, Divisional Headquarters teaching hospital, Mirpurand Isra Medical University, Karachi for six months duration from 16thJune 2020 to 15thDecember 2020. The clinical feature assesses HCV exposure in all patients, biochemical data, and iron status parameters. The results were quantified using Microsoft Excel 2013. Results: The obtained outcomes indicate that antiviral treatment significantly interferes the iron accumulation in hepatocytes in HCV positive patients. All positive iron values were calculated as 19.93 mol / L; and for all negative PCR, the value was calculated at 24.61 μmol / L prior to drug started. Our patients’ levels of iron were 62.77 μmol / L in patients whose PCR is positive for HCV which is within the normal range. Reduced ferritin levels have negative effects after drug administration. The increase in ALT was observed in 37.62% of cases. Conclusions: Patients with chronic HCV have strong association with serum iron concentration. Keywords: Ferritin levels, Drugs, Iron load, Hepatitis C Virus Infection, Serum and Liver Cells.

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Section: Discussionmentioning

confidence: 99%

Assessing Responsiveness of Elevated Serum Ferritin for Treatment in Chronic Hepatitis C Infected Patients

Iqbal¹,

Baig²,

Ali³

et al. 2021

PJMHS

View full text Add to dashboard Cite

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“…Assessing Hb-ret in the detection of ID was recently proposed in chronic hepatitis C patients [30] and in patients with Helicobacter pylori infection [31].…”

Section: Id Screening In Thalassemia Patientsmentioning

confidence: 99%

Reticulocyte haemoglobin content: 2020 update

Eremina

Magalhaes

2020

I.P. Pavlov Russian Medical Biological Herald

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The hemoglobin content of reticulocytes (Hb-ret) is an effective real-time hemoglobin synthesis status indicator that permits diagnosis and monitoring of iron deficiency and iron deficiency anemia in all age groups with or without underlying diseases, including beta thalassemia. Hb-ret is less invasive than bone iron examination, less expensive than iron biochemical tests and might be available even in local laboratories. This review covers reports published mainly in 2020 and some other studies dedicated to clinical application of Hb-ret measured by Sysmex hematology analyzers.

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Serum hepcidin levels in chronic liver disease: a systematic review and meta-analysis

Sharma

Zhao

Zafar

et al. 2023

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Dysregulation of hepcidin-iron axis is presumed to account for abnormal iron status in patients with chronic liver disease (CLD). Our aim is to determine the effect of specific etiologies of CLD and of cirrhosis on serum hepcidin levels. Methods Pubmed, Embase, Web of Science were searched for studies comparing serum hepcidin levels in patients with CLD to that in controls using enzyme-linked immunosorbent assay. The study was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Guidelines. Statistical analysis was carried out with STATA using random effects model to calculate the mean difference (MD) between two groups. Results Hepcidin levels were significantly lower in subjects with hepatitis C virus (16 studies) [MD −1.6 (95 % CI: −2.66 to −0.54), p<0.01] and alcoholic liver disease (3 studies) [MD −0.84 (95 % CI: −1.6 to −0.07), p=0.03] than controls. Serum hepcidin was significantly higher in subjects with non-alcoholic fatty liver disease (12 studies) [MD 0.62 (95 % CI: 0.21 to 1.03), p<0.01], but did not differ in subjects with hepatitis B and controls (eight studies) [MD −0.65 (95 % CI: −1.47 to 0.16), p=0.12]. Hepcidin levels were significantly lower in patients with cirrhosis of any etiology (four studies) [MD −1.02 (CI: −1.59 to −0.45), p<0.01] vs. controls (CI: confidence interval). Conclusions Serum hepcidin levels are altered in common forms of CLD albeit not in a consistent direction. Additional study is needed to determine how changes in hepcidin levels are related to dysregulation of iron metabolism in CLD.

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Influence of esophageal variceal bleeding on iron status in chronic hepatitis C patients

Cited by 3 publications

References 35 publications

Assessing Responsiveness of Elevated Serum Ferritin for Treatment in Chronic Hepatitis C Infected Patients

Assessing Responsiveness of Elevated Serum Ferritin for Treatment in Chronic Hepatitis C Infected Patients

Reticulocyte haemoglobin content: 2020 update

Serum hepcidin levels in chronic liver disease: a systematic review and meta-analysis

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