Influence of Ergot Alkaloids on Growth of<i>Streptomyces purpurascens</i>and Production of its Secondary Metabolites

Schwarz, Gerhard; Eich, Eckart

doi:10.1055/s-2007-969988

Cited by 27 publications

(11 citation statements)

References 2 publications

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“…Based on limited laboratory research, ergopeptines appear to be particularly active against insects and nematodes, whereas clavine alkaloids are less active against these invertebrate eukaryotes [6,7]. Conversely, clavine alkaloids have been shown to have antibacterial and cytostatic activity that is superior to that of ergopeptines or simple amides of lysergic acid [9,10,36].…”

Section: Evidence For Functional Differences Among Structurally Divementioning

confidence: 99%

“…Ergot alkaloids exhibit clear differences in their antimicrobial and cytostatic properties. Clavine alkaloids (particularly agroclavine and festuclavine) were shown to be effective antimicrobial compounds, whereas ergotamine (an ergopeptine) and ergonovine (a simple amide of lysergic acid) were not [9,10]. Similarly, agroclavine and festuclavine (and their synthetic derivatives) had significant cytostatic activity to a mouse lymphoma cell line, whereas four lysergic acid derivatives (including ergine and LSD) did not[36].…”

Section: Evidence For Functional Differences Among Structurally Divementioning

confidence: 99%

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Origins and significance of ergot alkaloid diversity in fungi

Panaccione

2005

FEMS Microbiology Letters

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Ergot alkaloids are a diverse family of indole-derived mycotoxins that collectively have activities against a variety of organisms including bacteria, nematodes, insects, and mammals. Different fungi accumulate different, often characteristic, profiles of ergot alkaloids rather than a single pathway end product. These ergot alkaloid profiles result from inefficiency in the pathway leading to accumulation of certain intermediates or diversion of intermediates into shunts along the pathway. The inefficiency generating these ergot alkaloid profiles may have been selected for as a means of accumulating a diversity of ergot alkaloids, potentially contributing in different ways to benefit the producing fungus.

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Section: Evidence For Functional Differences Among Structurally Divementioning

confidence: 99%

Section: Evidence For Functional Differences Among Structurally Divementioning

confidence: 99%

Origins and significance of ergot alkaloid diversity in fungi

Panaccione

2005

FEMS Microbiology Letters

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“…The ecological roles of ergot alkaloids are poorly understood; however they have activities against mammals, insects, nematodes and bacteria (Schwarz and Eich 1983, Clay and Cheplick 1989, Ball et al 1997, Clay and Schardl 2002. Their effects on humans are thought to be mediated by their agonistic and/or antagonistic interactions with monoamine neurotransmitter receptors (Pertz 1996, Grö ger and Floss 1998, Pertz and Eich 1999.…”

Section: Introductionmentioning

confidence: 99%

Association of ergot alkaloids with conidiation inAspergillus fumigatus

Coyle¹,

Kenaley²,

Rittenour³

et al. 2007

Mycologia

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Ergot alkaloids are mycotoxins that affect the nervous and reproductive systems of exposed individuals through interactions with monoamine receptors. They have been studied more widely in ergot fungi and grass endophytes but also are found in Aspergillus fumigatus, an opportunistic human pathogen that reproduces and disseminates exclusively through conidia. The ergot alkaloids festuclavine and fumigaclavines A, B and C are present in or on conidia of A. fumigatus. Cultures of the fungus that are free of conidia are difficult to obtain, obscuring comparisons of conidia versus vegetative hyphae as sources of the ergot alkaloids. To create conidiation-deficient strains of A. fumigatus we manipulated the bristle A gene (brlA), which controls vesicle formation or budding growth necessary for conidiation in Aspergillus spp. Disruption of brlA in A. fumigatus, via homologous recombination, resulted in a nonconidiating mutant that produced bristle-like structures instead of conidiophores and conidia. Moreover the disrupted strain failed to produce ergot alkaloids as verified by HPLC analyses. Complementation with a wild-type allele restored conidiation and ergot alkaloid production. These results suggest that ergot alkaloids are not produced within the vegetative mycelium of the fungus and are associated directly with conidiation.

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“…Agroclavine interrupted early pregnancy in mice when given orally but not after subcutaneous application (Mantle 1969), and potentiated hippocampal EEG effects of weak combined magnetic field in rats (Vorobyova et al 2009 Fig. 1 Chemical structure of the basic ergoline ring system, some clavines, and some lysergic acid derivatives seem to have antibacterial effects (Schwarz and Eich 1983).…”

Section: Introductionmentioning

confidence: 99%

Production and characterization of antibodies against fumigaclavine A

et al. 2009

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Polyclonal antibodies against fumigaclavine A (FuA) were obtained from rabbits after immunization with a FuA-keyhole limpet hemocyanine conjugate prepared by formaldehyde condensation. Using these antibodies and a FuA-bovine serum albumine conjugate, a competitive indirect enzyme immunoassay (EIA) was established. The antiserum obtained from one rabbit enabled highly sensitive detection of FuA, with an IC50 level and detection limit of the standard curve of 3.3 ng/ml and approx. 1 ng/ml, respectively. The EIA was very specific for FuA, with 1.3% cross-reactivity with FuB. Several other lysergic acid derivatives (ergonovine, ergotamine, alpha-ergocryptine) were tested but did not cross-react in the FuA EIA. This is the first description of antibodies against FuA and the first development of an EIA for FuA.

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Influence of Ergot Alkaloids on Growth ofStreptomyces purpurascensand Production of its Secondary Metabolites

Cited by 27 publications

References 2 publications

Origins and significance of ergot alkaloid diversity in fungi

Origins and significance of ergot alkaloid diversity in fungi

Association of ergot alkaloids with conidiation inAspergillus fumigatus

Production and characterization of antibodies against fumigaclavine A

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