Influence of epileptogenic region on brain structural changes in Rolandic epilepsy

Progressive structural damage in sleep‐related hypermotor epilepsy

“…We speculate that this is the main reason why its structural alterations are easily affected by other regions. In addition, we found GC values from brain regions to the supramarginal gyrus were all negative, which may be due to the asynchronous developmental effect of epilepsy and the compensatory effect of the brain (Xu et al, 2022; Zhang et al, 2017). Taken together, our study applies GCA to cross‐sectional structural data to construct CaSCN that can endow them with temporal properties, revealing the progressive changes in brain structure in patients with SHE as the disease progresses.…”

“…We speculate that this is the main reason why its structural alterations are easily affected by other regions. In addition, we found GC values from brain regions to the supramarginal gyrus were all negative, which may be due to the asynchronous developmental effect of epilepsy and the compensatory effect of the brain (Xu et al, 2022;Zhang et al, 2017).…”

“…As a result, the seizures become more severe, and the epileptic brain networks are further expanded. When the frontal lobe as a common transitional area is involved (Xu et al, 2022), its GMV was reduced. Repeated epileptic seizures also have a cumulative effect on the cerebellar GMV (Crooks et al, 2000; Salcman et al, 1978); hence, with the progression of epilepsy, the cerebellar GMV becomes smaller.…”

“…Neuroimaging techniques have been widely used in research on epilepsy in recent years. In other types of epilepsy (such as temporal lobe epilepsy and idiopathic generalized epilepsy), a variety of brain structural alterations can be observed using magnetic resonance imaging (MRI) (Xu et al, 2022; Zhang et al, 2017), including microstructure damage of gray matter or white matter. These structural brain alterations suggest that epileptic seizures involve multiple regions and provide morphological evidence for clinical symptoms, complex behaviors, and psychological complications, as well as potential information for clinical surgery and subsequent treatment.…”