Multinucleon transfer reactions near the Coulomb barrier have been investigated based on the improved dinuclear system (DNS) model, and the deexcitation process of primary fragments are described by statistical model GEMINI++. The production cross sections of $^{40,48}$Ca+$^{124}$Sn and $^{64}$Ni+$^{130}$Te based on the DNS model+GEMINI++ have been calculated and compared with the experimental data. The calculated results have reproduced the experimental data. The cross sections of fusion-evaporation reaction, fragmentation reaction and multinucleon transfer reaction in the $40 \leq Z \leq 60$ region are also given in this paper. The results show that in the $40 \leq Z \leq 60$ region, fusion-evaporation and fragmentation reactions have good results in the relatively proton-rich region, but in the extreme proton-deficient region, the MNT reaction is still promising to synthesize proton-rich nuclei.