2020
DOI: 10.1111/trf.15680
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Influence of enteral feeding and anemia on tissue oxygen extraction after red blood cell transfusion in preterm infants

Abstract: BACKGROUND Understanding factors that impact tissue oxygen extraction may guide red blood cell (RBC) transfusion decision making in preterm infants. Our objective was to assess the influence of enteral feeding and anemia on cerebral and mesenteric oxygen saturation (Csat and Msat) and fractional tissue oxygen extraction (cFTOE and mFTOE) over the entire time course of RBC transfusion. STUDY DESIGN AND METHODS Preterm, very low‐birth‐weight infants receiving RBC transfusions at a single center were enrolled. Ne… Show more

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Cited by 6 publications
(11 citation statements)
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“…In preterm infants receiving RBC transfusions according to local protocols, anemia was associated with lower r c SO 2 in most cases (30,39,40,44), but Wardle et al found similar cFTOE between anemic infants and controls (49). In the latter study, however, many babies were transfused based on physician discretion, rather than on the cFTOE cut-off levels mentioned in their study protocol.…”
Section: Anemia Rbc Transfusions and Cerebral Oxygenationmentioning
confidence: 78%
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“…In preterm infants receiving RBC transfusions according to local protocols, anemia was associated with lower r c SO 2 in most cases (30,39,40,44), but Wardle et al found similar cFTOE between anemic infants and controls (49). In the latter study, however, many babies were transfused based on physician discretion, rather than on the cFTOE cut-off levels mentioned in their study protocol.…”
Section: Anemia Rbc Transfusions and Cerebral Oxygenationmentioning
confidence: 78%
“…The majority (83%) of the 18 studies that reported on cerebral oxygenation during and after RBC transfusion found r c SO 2 to be higher during and after RBC transfusion compared to pretransfusion levels in anemic preterm infants (7,15,30,34,35,39,(41)(42)(43)(44)(45)(46)(47)(48)(49). Non-significant changes in cerebral oxygen saturation during and after RBC transfusions were observed in 3 studies (32,33,36).…”
Section: Anemia Rbc Transfusions and Cerebral Oxygenationmentioning
confidence: 98%
See 2 more Smart Citations
“…Approximately, 50-95% of low birth weight (<1500 g) and 95% of extremely low birth weight (<1000 g) infants receive erythrocyte transfusion (ET) at least once during their stay in neonatal intensive care unit (NICU) after birth (8,9). ET administered to 90% of extremely low birth weight and 58% of premature infants with gestational age <32 weeks (10)(11)(12)(13). Tranfusion increases amount of circulating hemoglobin, improves tissue oxygenation, maintains same oxygen level by decreasing cardiac output (10,14).…”
Section: Introductionmentioning
confidence: 99%