Influence of endurance training and marathon running on red cell deformability in HIV patients

Ahmad, Basit; Glufke, Katharina; Grau, Marijke; Sandig, Dennis; Rockstroh, Jürgen K.; Vogel, Martin; Wasmuth, Jan‐Christian; Bloch, Wilhelm; Brixius, Klara

doi:10.3233/ch-131767

Cited by 5 publications

(2 citation statements)

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“…Published data on the effect of exercise on RBC deformability are inconsistent and explained by variation in exercise intensity and volume, study population tested and/or deformability measuring devices applied (Connes et al, 2013). More recent data suggest a beneficial effect of both, acute exercise and chronic training on RBC deformability in healthy and diseased participants (Gürcan et al, 1998; Smith et al, 1999; Suhr et al, 2012; Ahmad et al, 2013, 2014; Koliamitra et al, 2017; Tomschi et al, 2018a). The data presented herein are thus in line with the cited literature indicating that even moderate training might positively affect RBC function.…”

Section: Discussionmentioning

confidence: 99%

“…Increased deformability levels have been shown for endurance athletes (Smith et al, 1999; Tomschi et al, 2018a) and associated to improved performance capacity (Koliamitra et al, 2017; Tomschi et al, 2018b). Exercise was thus described to positively affect RBC function in both, health and disease (Mairbäurl, 2013; Ahmad et al, 2014; Brinkmann et al, 2016; Koliamitra et al, 2017). In fact, endurance exercise increases shear stresses applied to the RBC which increases RBC-NOS dependent NO production (Suhr et al, 2012) and this was related to increased performance parameters.…”

Section: Introductionmentioning

confidence: 99%

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Comparisons of Blood Parameters, Red Blood Cell Deformability and Circulating Nitric Oxide Between Males and Females Considering Hormonal Contraception: A Longitudinal Gender Study

et al. 2018

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Red blood cell (RBC) deformability is an important determinant of the microcirculation. It is influenced by various hematological parameters but also by nitric oxide (NO) which is produced in RBC from L-arginine by RBC-NO synthase. Longitudinal studies on blood profile, deformability at rest and NO levels but also differences between males and females (±hormonal contraception; HC) are less known so far. The study thus aimed to investigate RBC deformability, RBC NO species (nitrite, RxNO), RBC L-arginine concentration and basal blood parameters in males and females (±HC) as a function of time. RBC deformability was measured at rest once per week and the remaining parameters were measured once per month, respectively. A second experiment aimed to daily measure RBC deformability and 17β-estradiol in Female ± HC during a whole menstruation cycle to investigate a possible relation of the two parameters. Measured parameters showed low week-to-week variation and remained constant during study period. However, RBC deformability increased in Female + HC during study period possibly because of increasing training volume of the participants. Overall, results indicate gender differences in hematological parameters with higher RBC parameters (RBC count, hematocrit, hemoglobin concentration) in males compared to females. Differences were also observed between the female groups with Females - HC showing lower number of RBC but higher MCV and hematocrit compared to Females + HC. RBC deformability was highest in Females - HC which might be related to permanent higher estradiol levels and/or higher RBC NO levels because RBC nitrite and RBC RxNO concentrations were also highest in Females-HC. Results of the second experiment also suggest higher RBC deformability in Female - HC because of higher estradiol concentrations. L-arginine levels known to be related to RBC NO production were comparable in all groups. In conclusion, hematological, hemorheological and NO related parameters show gender differences. In particular, RBC deformability is affected by training volume and RBC estradiol concentrations. The results add new information on the complex regulation of RBC function which might help to better understand the role of RBC in the microcirculation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparisons of Blood Parameters, Red Blood Cell Deformability and Circulating Nitric Oxide Between Males and Females Considering Hormonal Contraception: A Longitudinal Gender Study

et al. 2018

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Sport und HIV-Erkrankung

Mooren¹,

Fink²

2016

Therapie Und Prävention Durch Sport, Band 3

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Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

Grau

Jerke

Nader

et al. 2019

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Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subjects reached the first ventilatory threshold (VT 1). Blood was sampled at rest and at VT 1. At rest, free haemoglobin level was higher and RBC count, haemoglobin and haematocrit were lower in SCA compared to AA. RBC deformability was lower in SCA. Exercise had no effect on the tested parameters. RBC NO level was higher in SCA compared to AA at rest and significantly decreased after exercise in SCA. This might be related to a reduction in RBC-NO synthase (RBC-NOS) activation which was only observed in SCA after exercise. Free radical levels were higher in SCA at rest but concentration was not affected by exercise. Marker for lipid peroxidation and antioxidative capacity were similar in SCA and AA and not affected by exercise. In conclusion, a single acute submaximal bout of exercise has no deleterious effects on RBC deformability or oxidative stress markers in SCA, and seems to modulate RBC-NOS signalling pathway.

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Influence of endurance training and marathon running on red cell deformability in HIV patients

Cited by 5 publications

References 45 publications

Comparisons of Blood Parameters, Red Blood Cell Deformability and Circulating Nitric Oxide Between Males and Females Considering Hormonal Contraception: A Longitudinal Gender Study

Comparisons of Blood Parameters, Red Blood Cell Deformability and Circulating Nitric Oxide Between Males and Females Considering Hormonal Contraception: A Longitudinal Gender Study

Sport und HIV-Erkrankung

Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

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