Influence of Endodontic Procedure on the Adherence of Enterococcus faecalis

Xu, Jialei; He, Jinzhi; Shen, Ya; Zhou, Xuedong; Huang, Dingming; Gao, Yuan; Haapasalo, Markus

doi:10.1016/j.joen.2019.04.006

Cited by 28 publications

(22 citation statements)

References 31 publications

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“…CC-BY-NC-ND 4.0 International license made available under a (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is The copyright holder for this preprint this version posted August 10, 2020. ; https://doi.org/10.1101/2020.08.09.243485 doi: bioRxiv preprint to treated dentine surfaces [14], and its ability to tolerate nutrient-deprived environments encountered inside root canals [15]. That said, there is a critical need to develop alternative antimicrobials to improve root canal disinfection and prevent reinfection.…”

Section: Introductionmentioning

confidence: 99%

Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery

Ali

Cheung

Matinlinna

et al. 2020

Microbial Pathogenesis

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Enterococcus faecalis is a biofilm-forming, nosocomial pathogen that is frequently isolated from failed root canal treatments. Contemporary root canal disinfectants are ineffective in eliminating these biofilms and preventing reinfection. As a result, there is a pressing need to identify novel and safe antibiofilm molecules. The effect of short-term (5 and 15 min) and long-term (24 h) treatments of TC on the viability of E. faecalis biofilms was compared with currently used root canal disinfectants. Treatment for 15 min with TC reduced biofilm metabolic activity as effective as 1% sodium hypochlorite and 2% chlorhexidine. Treatment with TC for 24 h was significantly more effective than 2% chlorhexidine in reducing the viable cell counts of biofilms. This serendipitous effect of TC was sustained for 10 days under growthfavoring conditions. For the first time, our study highlights the strong antibacterial activity of TC against E. faecalis biofilms, and notably, its ability to prevent biofilm recovery after treatment.

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Section: Introductionmentioning

confidence: 99%

Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery

Ali

Cheung

Matinlinna

et al. 2020

Microbial Pathogenesis

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“…Extrusion might not only cause an in ammatory response but also provide a substrate for bacterial adhesion [20,21]. Although lling sealers have antibacterial activities, some bacteria, such as E. faecalis, still adhere to the surface of the materials [16,22]. Our studies also indicated that E. faecalis may survive on the surface of Apexit Plus, AH-Plus, tricalcium silicate-containing sealer, and gutta-percha.…”

Section: Discussionmentioning

confidence: 74%

The Effect of Serum Protein on Enterococcus Faecalis Adhesion to Three types of Root Sealers and Gutta-Percha

Lin¹,

Chi²,

Gong³

et al. 2021

Preprint

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The aim of this study was to evaluate the effect of serum protein on Enterococcus faecalis adhesion and survival on the surface of Apexit Plus (AP), AH-Plus (AH), a tricalcium silicate–containing sealer (Iroot SP) and gutta-percha (GP). AP, AH or Iroot SP was evenly coated on GP. After root sealers setting, the amount of E. faecalis adhering to the sealers was evaluated in fetal bovine serum (FBS) or TSBG medium by viable cell plate counts. The morphology of the sealers coated on GP and 7-day-old E. faecalis biofilm was observed by scanning electron microscopy (SEM). Furthermore, the ratios of viable and dead cells in biofilm were calculated by a Carl Zeiss confocal laser scanning microscope (CLSM) and ZEN software. In 1 and 7 days of assays, the amount of E. faecalis adhering to the surface of sealers or GP in FBS was significantly less than in TSBG (P < .05). FBS more significantly reduced the bacterial amount on the SP and GP than on the AP and AH. E. faecalis biofilm on the AP and SP were more typical in the TSBG than in the FBS. The ratio of viable cell in the E. faecalis biofilm was the lowest on the SP by CLSM. It can be stated that Apexit Plus, AH-Plus and Iroot SP sealers may provide the substrate for E. faecalis adhesion, and the serum proteins significantly influenced bacterial adhesion to the surface of Apexit Plus, AH-Plus, Iroot SP and gutta-percha.

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“…When a new chemical is being evaluated as a smear layer removal agent, it is important to consider its effect on the chemical and physical characteristics of dentine by measurement of dentinal roughness and microhardness. The changes in roughness reflect altered topography and wettability of dentine, which might have an effect on the microbial and dental materials adhesion to dentine (Eick et al, 1972;Attal et al, 1994;Hu et al, 2010;Xu et al, 2019). A change in microhardness denotes an effect on the mineral content of dentine represented mainly by the calcium:phosphorus ratio (Hennequin et al, 1994;Dogan and Çalt, 2001).…”

Section: Chelating Agentmentioning

confidence: 99%

Phytic Acid: Properties and Potential Applications in Dentistry

Nassar

Maki

et al. 2021

Front. Mater.

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Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with an immense chelating ability and valuable antioxidant properties. IP6 is also simple and cost-effective to produce. These features have attracted researchers and entrepreneurs to further study IP6 for a wide variety of applications in areas such as pharmaceutical, food and chemical industries, medicine, pharmacy, nutrition, and dentistry. The interest in IP6 in the dental field unfolded many decades ago following identification of a cariostatic ability and a positive impact on reducing enamel dissolution. Subsequently, IP6’s anti-plaque, anti-calculus and cement-forming properties have been investigated. Despite encouraging findings, there was a phase of decreased attention to IP6 which slowed down research progress. However, the potential use of IP6 has recently been revisited through several publications that provided deeper understanding into its mechanisms of action in the aforementioned applications. Studies have also explored new applications in endodontics, adhesive, preventive and regenerative dentistry, and IP6’s role in improving the characteristics and performance of dental materials. Evidence of the merits of IP6 in dentistry is now substantial, and this narrative review presents and discusses the different applications proposed in the literature and gives insights of future use of IP6 in the fields of orthodontics, implant and pediatric dentistry.

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Influence of Endodontic Procedure on the Adherence of Enterococcus faecalis

Cited by 28 publications

References 31 publications

Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery

Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery

The Effect of Serum Protein on Enterococcus Faecalis Adhesion to Three types of Root Sealers and Gutta-Percha

Phytic Acid: Properties and Potential Applications in Dentistry

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