Influence of embryo sex on development to the blastocyst stage and euploidy

Eaton, Jennifer L.; Hacker, Michele R.; Barrett, C.B.; Thornton, Kim L.; Penzias, Alan S.

doi:10.1016/j.fertnstert.2010.06.063

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…Another study also reported similar euploidy rates for males and females, but found that there was a trend towards females developing faster during the cleavage-stage embryos and males developing faster as blastocysts, although these differences were not significant [2]. A study of cleavagestage embryos also reported no ploidy differences by embryo sex, though not all chromosomes were tested [10].…”

Section: Introductionmentioning

confidence: 89%

“…Fragouli et al studied a cohort of 1213 mixed cleavage-stage and blastocyst embryos and reported no correlation between euploidy and embryo sex. Eaton et al reported that in a study of 758 cleavage-stage embryos which were tested for sex chromosomes and a subset of autosomal chromosomes, male and female embryos were equally likely to be euploid (for tested chromosomes) and achieve blastocyst stage [10].…”

Section: Embryo Sexmentioning

confidence: 99%

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Euploidy in relation to blastocyst sex and morphology

Wang

Kort

Behr

et al. 2018

J Assist Reprod Genet

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This is the largest study to date to investigate PGS-tested embryo sex and ploidy status. While maternal age and some morphological parameters (expansion, trophectoderm grade) are associated with euploidy in our cohort, other parameters such as embryo sex, biopsy day, and cohort size are not. Though embryo sex was not associated with euploidy, male embryos were found to be associated with higher trophectoderm grades. Additional investigation in larger studies is warranted.

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Section: Introductionmentioning

confidence: 89%

Section: Embryo Sexmentioning

confidence: 99%

Euploidy in relation to blastocyst sex and morphology

Wang

Kort

Behr

et al. 2018

J Assist Reprod Genet

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“…In the study by Eaton et al (2011), while no difference in development of day-3-biopsied embryos was seen among male and female embryos, male embryos were found to cleave significantly faster among day-5-biopsied embryos. However, a significant effect of embryo biopsy during early cleavage on the embryo development rate has been recently documented by morphokinetic analysis (Kirkegaard et al, 2012b), implying that the timing and the degree of interventions/ disturbances during early cleavage can also influence the sex ratios and embryo development.…”

Section: Discussionmentioning

confidence: 77%

“…They concluded that intrinsic characteristics of insemination procedures do affect embryo kinetics of development if insemination time is used as the starting point, but when pronuclear fading rather than time of insemination was established as t 0, the differences between the two procedures disappeared, implying that experimental settings in fact can change the outcome. Investigation of embryo development among biopsied embryos in preimplantation genetic diagnosis cycles has also been recently analysed to assess gender-specific characteristics (Alfarawati et al, 2011;Eaton et al, 2011). In the study by Alfarawati et al (2011), although similar and insignificant sex ratio was observed among blastocyst-stage embryos, sex-specific differences in the developmental rates (i.e.…”

Section: Discussionmentioning

confidence: 99%

Comparison of gender-specific human embryo development characteristics by time-lapse technology

Serdaroğullari¹,

Fındıklı²,

Göktaş³

et al. 2014

Reproductive BioMedicine Online

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Numerous studies indicate that there might be differences in embryo growth dynamics between male and female embryos. However, current data in humans are scarce and the results are inconclusive or conflicting. This study asks whether there exist gender-specific embryo development kinetics or parameters between human male and female embryos that can be observed by time-lapse technology. Study included data from 139 consecutive cycles (177 embryos transferred, 179 sacs analysed) with positive pregnancy that resulted in 100% implantation. Single- or double-embryo transfers were performed. Cases were analysed for parameters including cleavage time points and duration in each cleavage from two cells to hatching blastocyst stages and time interval between cleavages. Morphokinetic parameters of 78 female and 60 male embryos from a total of 119 cycles (139 sacs were examined after transfer of 138 embryos) were processed for data analysis according to the gender group. A detailed analysis of the data regarding each time point or interval between consecutive events according to these groups showed them to be similar in cell division kinetics, from the early cleavage through their development to blastocyst stage. However, female embryos showed earlier cavitation than male embryos, but the results did not reach statistical significance.

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“…Eventually, their study showed faster development and a high blastocyst score in male embryos. Nevertheless, Eaton et al found no significant difference in blastocyst formation rate between male and female embryos after they used FISH to analyze the chromosomal complement of 143 day-3 embryos [ 18 ].Our results showed that in the group of embryos with balanced molecular karyotype, male embryos had a higher blastocyst formation rate (59.3%) than female embryos (54.0%) although there was no significant difference ( P = 0.172), suggesting that embryonic gender had no significant influence on blastocyst formation rate.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Single Nucleotide Polymorphism Microarray-Based Molecular Karyotype on Preimplantation Embryonic Development Potential

Jin

et al. 2015

PLoS ONE

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In order to investigate the influence of the molecular karyotype based on single nucleotide polymorphism (SNP) microarray on embryonic development potential in preimplantation genetic diagnosis (PGD), we retrospectively analyzed the clinical data generated by PGD using embryos retrieved from parents with chromosome rearrangements in our center. In total, 929 embryos from 119 couples had exact diagnosis and development status. The blastocyst formation rate of balanced molecular karyotype embryos was 56.6% (276/488), which was significantly higher than that of genetic imbalanced embryos 24.5% (108/441) (P<0.001). No significant difference was detected in blastocyst formation rates in the groups of maternal age<30, 30–35 and >35 respectively. Blastocyst formation rates of male and female embryos were 44.5% (183/411) and 38.8% (201/518) respectively, with no significant difference between them (P>0.05). The rates of balanced molecular karyotype embryos vary from groups of embryos with different cell numbers at 68 hours after insemination. The blastocyst formation rate of embryos with 6–8 cells (48.1%) was significantly higher than that of embryos with <6 cells (23.9%) and with >8 cells (42.9%) (P<0.05). As for the unbalanced embryos, there was no significant difference of the distribution of abnormal molecular karyotypes in the subgroup of the arrest, morula and blastocyst. Thus, we conclude that embryos with balanced molecular karyotype have significant higher development potential than those with imbalanced molecular karyotype whilst maternal age, embryo gender and types of abnormal molecular karyotype have no significant influence on blastocyst formation. Compared with embryos with <6 and >8 cells, embryos with 6–8 blastomeres have higher rate of balanced molecular karyotype and blastocyst formation.

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Influence of embryo sex on development to the blastocyst stage and euploidy

Cited by 12 publications

References 47 publications

Euploidy in relation to blastocyst sex and morphology

Euploidy in relation to blastocyst sex and morphology

Comparison of gender-specific human embryo development characteristics by time-lapse technology

The Influence of Single Nucleotide Polymorphism Microarray-Based Molecular Karyotype on Preimplantation Embryonic Development Potential

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