Influence of ellagic acid on prostate cancer cell proliferation: A caspase–dependent pathway

Malik, Arshi; Afaq, Sarah; Shahid, Mohammad; Akhtar, Kafil; Assiri, Abdullah

doi:10.1016/s1995-7645(11)60144-2

Cited by 66 publications

(50 citation statements)

References 17 publications

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“…Moreover, the increase in apoptosis upon incubation with urolithins was correlated with a decrease in the expression of Bcl-2, a critical regulator of the apoptotic pathway, and a potent suppressor of apoptosis. 62 Human tumors usually express high levels of Bcl-2 protein and in prostate cancer its levels correlate with high levels of PSA. 36 Thus, the decrease in Bcl-2 and the apoptotic activity induced upon incubation with urolithins could be linked to the inhibition of PSA by these compounds.…”

Section: Discussionmentioning

confidence: 99%

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

et al. 2014

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Walnuts have been gathering attention for their health-promoting properties. They are rich in polyphenols, mainly ellagitannins (ETs) that after consumption are hydrolyzed to release ellagic acid (EA). EA is further metabolized by microbiota to form urolithins, such as A and B, which are absorbed. ETs, EA and urolithins have shown to slow the proliferation and growth of different types of cancer cells but the mechanisms remain unclear. We investigate the role of urolithins in the regulatory mechanisms in prostate cancer, specifically those related to the androgen receptor (AR), which have been linked to the development of this type of cancer. In our study, urolithins down-regulated the mRNA and protein levels of both prostate specific antigen (PSA) and AR in LNCaP cells. The luciferase assay performed with a construct containing three androgen response elements (AREs) showed that urolithins inhibit AR-mediated PSA expression at the transcriptional level. Electrophoretic mobility shift assays revealed that urolithins decreased AR binding to its consensus response element. Additionally, urolithins induced apoptosis in LNCaP cells, and this effect correlated with a decrease in Bcl-2 protein levels. In summary, urolithins attenuate the function of the AR by repressing its expression, causing a down-regulation of PSA levels and inducing apoptosis. Our results suggest that a diet rich in ET-containing foods, such as walnuts, could contribute to the prevention of prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

et al. 2014

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“…Programmed cell death or apoptosis performs an essential role for balancing cell proliferation and cell death and contributes to an effective cancer therapy [17][18][19][20][21][22][23][24] . Several anticancer activity studies have defined apoptosis as the pharmaco-dynamic endpoint for anti-cancer treatment [25] .…”

Section: Discussionmentioning

confidence: 99%

Anticancer effect of the extracts from Polyalthia evecta against human hepatoma cell line (HepG2)

Machana

Weerapreeyakul

Barusrux

2012

Asian Pacific Journal of Tropical Biomedicine

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“…Pomegranate extracts has been shown to inhibit both androgen-dependent and androgen-independent prostate cancer cell growth. Since androgen and AR play central roles throughout prostate cancer development Hong et al (2008) Since the anticarcinogenic activity of ellagic acid, the main polyphenol in the pomegranate, has been shown on several cancer types Malik et al (2011) evaluated the effect of ellagic acid treatment on the cell viability of human prostate cancer cells. They observed that ellagic acid (10-100 mol/L) treatment (48 h) of human prostate carcinoma PC3 cells resulted in a dose dependent inhibition of cell growth/cell viability.…”

Section: Prevention Of Prostate Cancermentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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Influence of ellagic acid on prostate cancer cell proliferation: A caspase–dependent pathway

Abstract: It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer.

Cited by 66 publications

References 17 publications

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

Anticancer effect of the extracts from Polyalthia evecta against human hepatoma cell line (HepG2)

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

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