Influence of elevated content of cadmium and arsenic in diet containing feeding yeast on organisms of rats

Abstract

The influence of elevated cadmium content in diet on the content of this element in liver, kidney and testes of 68 male rats was studied in dependence on the chemical form of applied cadmium (as inorganic salt – CdCl<sub>2</sub> and organically bound in yeast cells); the influence of elevated arsenic content (as NaAsO<sub>2</sub>) in diet on its content in the same organs was also investigated. The interactions between arsenic and cadmium in the above-mentioned organs were studied. The addition of cadmium to the diet of rats significantly (<I>P</I> < 0.05) increased cadmium content in several organs. The addition of yeast containing the natural level of Cd increased the content of cadmium in liver and kidney of experimental animals significantly (<I>P</I> < 0.05). A significantly (<I>P</I> < 0.05) increased cadmium accumulation in organs was observed after the addition of Cd as CdCl<sub>2</sub>, compared with the addition of Cd as organically bound Cd in yeast cells. At the same time, the addition of yeasts containing the natural level of Cd decreased the Cd accumulation applied as CdCl2 in the examined organs. The addition of sodium arsenite to the diet of rats led to a significantly (<I>P</I> < 0.05) increased arsenic content in all the analyzed organs. The addition of yeasts to the diet increased arsenic content in liver and at the same time suppressed its content in kidneys of experimental animals. The interaction between arsenic and cadmium applied simultaneously was evident. The addition of As to the diet decreased the accumulation of Cd in kidney and increased its accumulation in testes. The addition of Cd to the diet increased arsenic content in liver and kidney and decreased its content in testes.

Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model

“…Moreover, the form and/or compound of applied element should be taken into account. Szakova et al (2009) In their experiment, higher Cd contents were found in kidney and liver of the rats fed organic form of Cd compared to CdCl 2 (but without any difference in the case of MT contents) because of high soluble Cd-MT fraction in snails bioavailable to rats. In our case, the significant difference was observed between oral exposure of CdCl 2 in water and in the diet where lower bioavailability was observed for the Cd application in the diet, as expectable.…”

“…A common model used in toxicology to estimate the potential hazard of contaminants for human health is rat, where after exposition to Cd, induction of MT in several tissues, especially in liver, has been well documented (Chan et al 1992a, Szakova et al 2009). Comparing to liver, Cd induces MT to a lesser extent in the testes indicating the higher susceptibility of testis to Cd toxicity.…”

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

“…As already published, the interaction between arsenic and cadmium applied simultaneously is evident. The addition of Cd to the diet can significantly increase arsenic contents in liver and kidney of rats fed the diet containing Cd-enriched yeasts (Szakova et al 2009). Similarly, rats treated with As + Cd had more As in heart tissue than rats treated only with arsenic (Yanez et al, 1991).…”

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“…This supports the observations reported 28,29 both As and Cd decreased body weight gain and food utilization and that these effects were more pronounced for the mixture. Available reports 30,31,32 also indicate that long term exposure to arsenic and cadmium could lead to significant reduction in body weights.…”