Influence of electron beam irradiation on physicochemical properties of poly(trimethylene carbonate)

Jozwiakowska, Joanna; Wach, Radosław A.; Rokita, Bożena; Ulański, Piotr; Nalawade, Sameer P.; Grijpma, Dirk W.; Feijén, Jan; Rosiak, Janusz M.

doi:10.1016/j.polymdegradstab.2011.05.010

Cited by 15 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, PTMC does not undergo instant degradation but EB irradiation causes both degradation and intermolecular cross‐linking occurring simultaneously. Irradiation of PTMC with doses sufficient enough results in an increase in its molecular weight and eventually in formation of insoluble fraction – gel 21. In the present investigations, reduction of molecular weight of PLLA and nearly unaffected molecular weight of PTMC were observed for polymers irradiated separately by EB with a standard sterilization dose of 25 kGy – Table I.…”

Section: Resultssupporting

confidence: 58%

“…Therefore, we can assume that, in spite of the degradation or crosslinking reactions that is related to molecular mass change, the chemical composition of macromolecules was retained or at least the changes are minor. Indeed, chemical structures of PTMC21 and PLLA40, 41 subjected to 25 kGy, and evaluated by other physicochemical methods, were reported to be nearly unaffected.…”

Section: Resultsmentioning

confidence: 99%

“…To effectively increase the molecular weight and therefore to modify the properties of PTMC, ionizing radiation by means of electron beam (EB) can be applied. Linear chains of PTMC undergo radiation‐induced cross‐linking, which in turn may result in improved mechanical properties of this polycarbonate 21. PTMC has been investigated for biomedical applications in soft tisse engineering,22, 23 drug delivery systems24 and scaffolds for nerve regeneration 25.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nerve guidance channels based on PLLA–PTMC biomaterial

Wach

Adamus

Olejnik

et al. 2012

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Biodegradable polymers of poly(lactic acid) (PLLA) and synthesized in-house poly(trimethylene carbonate) (PTMC) with admixture of water-soluble methyl cellulose (MC) were used for development of nerve guidance tubes for peripheral nervous system regeneration after injury. Fabrication method involved phase separation of viscous dixane solution of polymers mixture seat on a rod in a proper nonsolvent, which resulted in tubular structure of large porosity. Influence of electron beam sterilization on molecular weight, thermal properties of the polymers, and mechanical performance of the tubes was evaluated. Admixture of hydrophilic MC to synthetic polymers resulted in modification of mechanical properties of the channels. Extraction of MC showed potential of the tubes for releasing water-soluble bioactive molecules, such as for instance growth factors. Basic in vitro MTT and LDH assays showed no cytotoxic effect of manufactured tubes, therefore, animal experimentations may be considered.

show abstract

Section: Resultssupporting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nerve guidance channels based on PLLA–PTMC biomaterial

Wach

Adamus

Olejnik

et al. 2012

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, biodegradable porous materials or those with voids of specific characteristics should not be sterilized by surface sterilization methods, rather by penetrating techniques. Since thermal methods are not applicable to polymers with low T g and T m or to biodegradable polymers, radiation may be the required solution . While the radiation method is used for polymeric biomaterials, one should consider potential changes of properties at either molecular and macroscopic level.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Mechanical Properties of FDM‐PLA Parts via Thermal Annealing

Wach

Wolszczak

Adamus-Włodarczyk

2018

Macro Materials & Eng

Self Cite

162

View full text Add to dashboard Cite

The objective of this study is to investigate the possibility of enhancing mechanical properties of poly(lactic acid) (PLA) samples processed by a rapid manufacturing (RM) technique by increasing PLA crystallinity degree via thermal annealing. The samples are manufactured by fused deposition modeling (FDM) at different temperatures and subsequently evaluated by three‐point bending flexural and tensile tests. The polymer processed at 215 °C is thermally annealed over its glass transition temperature in order to increase the degree of crystallinity to the maximum attainable level as measured by the differential scanning calorimetry and confirmed by X‐ray diffraction. The increase in the degree of crystallinity of FDM‐PLA enhances flexural stress of the samples by 11–17%. The study also demonstrates applicability of radiation sterilization for FDM‐PLA parts. Therefore, thermal annealing might be introduced into a standard RM technology of PLA, particularly for sterilizable customized implants, to efficiently improve their mechanical properties.

show abstract

“…Studies on the influence of irradiation on these polymers, used here as a sterilisation tool for the neurotube implants, were described previously [ 21 ]. It is known that PTMC processed separately and in the blend tends to increase in molecular weight during irradiation by ionizing radiation [ 29 ]. Oppositely, polylactides degrade readily, so the important factor is their initial molecular weight that would determine the end product mechanical properties after radiation sterilisation [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Experimental research In vivo evaluation of nerve guidance channels of PTMC/PLLA porous biomaterial

Wach¹,

Adamus²,

Ludwicka³

et al. 2015

aoms

Self Cite

View full text Add to dashboard Cite

IntroductionPeripheral nerve disruptions, frequently occurring during limb injuries, give rise to serious complications of patients recovery resulting from limitations in neural tissue regeneration capabilities. To overcome this problem bridging techniques utilizing guidance channels gain their importance. Biodegradable polymeric tubes seem to be more prospective then non-degradable materials – no necessity of implant removal and possibilities of release of incorporated drugs or biologically active agents that may support nerve regeneration process are the main advantages.Material and methodsPolymer blend of commercial poly(L-lactic acid) (PLLA) and in-house synthesized poly(trimethylene carbonate) (PTMC) were processed in an organic solvent – phase inversion process on a supporting rod – to form a guidance porous tube of 1.1 mm inner diameter. In vivo experiments on rat's cut femoral nerve by using either the tubes or end-to-end suturing (control group) involved 22 and 19 rats, respectively. Motor recovery of operated limbs, neuroma occurrence and histopathology of explanted nerves were evaluated after 30, 60 and 90 days of implantation.ResultsMotor recovery of the limbs was of similar rate for the two animal groups. The neuroma formation was evident in over 90% control specimens, while for the bridging group it was less than 40% of all evaluable samples (p = 0.0022). Biocompatibility of applied materials was affirmed by moderate tissue response.ConclusionsApplication of the biodegradable PLLA/PTMC polymeric tubes effectively supports regeneration of discontinued nerves. The applied material prevents neuroma formation, by reducing the scar tissue formation time and, thus, accelerating the process of neural tissue restoration.

show abstract

Influence of electron beam irradiation on physicochemical properties of poly(trimethylene carbonate)

Cited by 15 publications

References 21 publications

Nerve guidance channels based on PLLA–PTMC biomaterial

Nerve guidance channels based on PLLA–PTMC biomaterial

Enhancement of Mechanical Properties of FDM‐PLA Parts via Thermal Annealing

Experimental research In vivo evaluation of nerve guidance channels of PTMC/PLLA porous biomaterial

Contact Info

Product

Resources

About