Influence of electrical and thermal properties on RF ablation of breast cancer: is the tumour preferentially heated?

Ekstrand, Vilhelm; Wiksell, Hans; Schultz, Inkeri; Sandstedt, Bengt; Rotstein, Samuel; Eriksson, Anders

doi:10.1186/1475-925x-4-41

Cited by 62 publications

(23 citation statements)

References 31 publications

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“…However, it is important to mention that, despite the temperature differences, the more important is that it was possible to obtain temperatures over 60 • C after 240 s, which means that tissue ablation was achieved in all cases. According to Ekstrand [50], ablation therapy is produced above 60 • C; between 43 and 60 • C, the cell damage is the result of the denaturation of proteins. Over 60 • C, the cell death is considered almost instantaneous.…”

Section: Discussionmentioning

confidence: 99%

Heat Transfer Study in Breast Tumor Phantom during Microwave Ablation: Modeling and Experimental Results for Three Different Antennas

et al. 2020

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It is worldwide known that the most common type of cancer among women is breast cancer. Traditional procedures involve surgery, chemotherapy and radiation therapy; however, these treatments are invasive and have serious side effects. For this reason, minimally invasive thermal treatments like microwave ablation are being considered. In this study, thermal behavior of three types of slot-coaxial antennas for breast cancer microwave ablation is presented. By using finite element method (FEM), all antennas were modeled to estimate the heat transfer in breast tumor tissue surrounded by healthy breast tissue. Experimentation was carried out by using the antennas inserted inside sphere-shaped-tumor phantoms with two different diameters, 1.0 and 1.5 cm. A microwave radiation system was used to apply microwave energy to each designed antenna, which were located into the phantom. A non-interfering thermometry system was used to measure the temperature increase during the experimentation. Temperature increases, recorded by the thermal sensors placed inside the tumor phantom surrounded by healthy breast phantom, were used to validate the FEM models. The results conclude that, in all the cases, after 240 s, the three types of coaxial slot antenna reached the temperature needed produce hyperthermia of the tumor volume considered in this paper.

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Section: Discussionmentioning

confidence: 99%

Heat Transfer Study in Breast Tumor Phantom during Microwave Ablation: Modeling and Experimental Results for Three Different Antennas

et al. 2020

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“…The Valencia Polytechnic University group began their modeling studies on RF heating of the cornea [ 17 , 48 , 49 ], and later developed models for RF cardiac ablation, specifically studying the problem of thermal injury in the esophagus during RF ablation of the left atrium [ 50 - 53 ]. In addition, other notable modeling studies have been developed for RF hepatic ablation [ 54 - 58 ], RF ablation of breast cancer [ 59 ], and RF cardiac ablation, incorporating both the heat convection due to blood circulation and the irrigation of saline on the epicardium [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

Theoretical modeling for radiofrequency ablation: state-of-the-art and challenges for the future

2006

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Radiofrequency ablation is an interventional technique that in recent years has come to be employed in very different medical fields, such as the elimination of cardiac arrhythmias or the destruction of tumors in different locations. In order to investigate and develop new techniques, and also to improve those currently employed, theoretical models and computer simulations are a powerful tool since they provide vital information on the electrical and thermal behavior of ablation rapidly and at low cost. In the future they could even help to plan individual treatment for each patient. This review analyzes the state-of-the-art in theoretical modeling as applied to the study of radiofrequency ablation techniques. Firstly, it describes the most important issues involved in this methodology, including the experimental validation. Secondly, it points out the present limitations, especially those related to the lack of an accurate characterization of the biological tissues. After analyzing the current and future benefits of this technique it finally suggests future lines and trends in the research of this area.

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“…The reflection coefficient calculated for the frequency at 2.45 GHz was -2.82 dB, the maximum temperature was 116.03 ºC, and the ablation zone radius was 53 mm. The isotherm was considered at 60 ºC because ablation is produced above this temperature [35]. Figure 4 shows the temperature distribution in breast cancer tissue.…”

Section: Materials Propertiesmentioning

confidence: 99%

High Temperature Hyperthermia in Breast Cancer Treatment

Rubio¹,

Salas²

2013

Hyperthermia

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Influence of electrical and thermal properties on RF ablation of breast cancer: is the tumour preferentially heated?

Cited by 62 publications

References 31 publications

Heat Transfer Study in Breast Tumor Phantom during Microwave Ablation: Modeling and Experimental Results for Three Different Antennas

Heat Transfer Study in Breast Tumor Phantom during Microwave Ablation: Modeling and Experimental Results for Three Different Antennas

Theoretical modeling for radiofrequency ablation: state-of-the-art and challenges for the future

High Temperature Hyperthermia in Breast Cancer Treatment

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