Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes

Yu, Kai; Andruschak, Paula; Yeh, Han Hung; Grecov, Dana; Kizhakkedathu, Jayachandran N.

doi:10.1016/j.biomaterials.2018.03.009

Cited by 39 publications

(36 citation statements)

References 73 publications

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“…The water contact angle decreased from 100.6 ± 2.6° on the pristine PU catheter to 33.1 ± 5.6° on coated one (Figure S2, Supporting Information), which is close to the water contact angle (35.1 ± 2.2°) on the grafted PDMA coating. [ 28 ] The result indicated the hydrophilic coating was enriched in PDMA on the top of the layer. Figure 2C shows the surface zeta potential of the bare PU and coated PU with PDA or PDA/uhPDMA.…”

Section: Resultsmentioning

confidence: 99%

Self‐Limiting Mussel Inspired Thin Antifouling Coating with Broad‐Spectrum Resistance to Biofilm Formation to Prevent Catheter‐Associated Infection in Mouse and Porcine Models

Alzahrani

Khoddami

et al. 2021

Adv Healthcare Materials

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Catheter‐associated urinary tract infections (CAUTIs) are one of the most commonly occurring hospital‐acquired infections. Current coating strategies to prevent catheter‐associated biofilm formation are limited by their poor long‐term efficiency and limited applicability to diverse materials. Here, the authors report a highly effective non‐fouling coating with long‐term biofilm prevention activity and is applicable to diverse catheters. The thin coating is lubricous, stable, highly uniform, and shows broad spectrum prevention of biofilm formation of nine different bacterial strains and prevents the migration of bacteria on catheter surface. The coating method is adapted to human‐sized catheters (both intraluminal and extraluminal) and demonstrates long‐term biofilm prevention activity over 30 days in challenging conditions. The coated catheters are tested in a mouse CAUTI model and demonstrate high efficiency in preventing bacterial colonization of both Gram‐positive and Gram‐negative bacteria. Furthermore, the coated human‐sized Foley catheters are evaluated in a porcine CAUTI model and show consistent efficiency in reducing biofilm formation by Escherichia coli (E. coli) over 95%. The simplicity of the coating method, the ability to apply this coating on diverse materials, and the high efficiency in preventing bacterial adhesion increase the potential of this method for the development of next generation infection resistant medical devices.

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Section: Resultsmentioning

confidence: 99%

Self‐Limiting Mussel Inspired Thin Antifouling Coating with Broad‐Spectrum Resistance to Biofilm Formation to Prevent Catheter‐Associated Infection in Mouse and Porcine Models

Alzahrani

Khoddami

et al. 2021

Adv Healthcare Materials

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“…16,23 Tightly controlled polymers pre-formed with a surface anchor group may also be grafted to a surface, but these brushes may be limited in molecular weight to enable efficient surface anchoring and hence require relatively high grafting densities to be effective. 18 Although recent work has continued to expand the potential applications of zwitterionic surface brushes from biomedical to membrane filtration and marine antifouling, [24][25][26][27][28] a clear advantage compared to other polymer designs is not always observed. 24,[29][30][31] The excellent antifouling properties of zwitterionic polymer brushes are frequently attributed to their high hydration by charge groups.…”

Section: Introductionmentioning

confidence: 99%

“…18 Although recent work has continued to expand the potential applications of zwitterionic surface brushes from biomedical to membrane filtration and marine antifouling, [24][25][26][27][28] a clear advantage compared to other polymer designs is not always observed. 24,[29][30][31] The excellent antifouling properties of zwitterionic polymer brushes are frequently attributed to their high hydration by charge groups. 2,7,13,[32][33][34] The water layer around highly hydrated phosphobetaine polymers has also been observed to display different dynamics from that around comparably hydrophilic polymers, 35 which is hypothesized to be related to improved biomedical performance.…”

Section: Introductionmentioning

confidence: 99%

Atomistic Study of Zwitterionic Peptoid Antifouling Brushes

Cheung

Lau

2018

Langmuir

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Using molecular dynamics (MD) simulations, we study the molecular behavior and hydration properties of a set of zwitterionic "peptoid" brushes, grafted on a rutile surface, that has been previously reported to exhibit excellent resistance against protein adsorption and cell attachment. Peptoids are novel poly( N-substituted glycine) peptide mimics with the side chains attached to amide nitrogens. They constitute a unique model polymer system because hundreds of side chains have been demonstrated, and the exact chain length and sequence order of the residues/monomers may be specified in experiments. In this report, we vary the brush grafting density as well as the side chain/polymer molecular volume. We include in our study polysarcosine as an uncharged comparison with a small polymer chain cross-section. Sarcosine is the simplest peptoid residue with only a nominally hydrophobic methyl group as side chain, but is also reported to exhibit high antifouling performance. Overall, we show in detail how molecular volume and hydration effects are intertwined in a zwitterionic polymer brush. For example, the zwitterionic design significantly promotes extended chain conformations and could actually lower the overall electrostatic potential. Some properties promoted by the balanced charges, such as chain flexibility and hydration, increase more prominently at "low" to "intermediate" chain densities. These and other observations should provide insight on the molecular behavior of peptoids and inform the design of zwitterionic antifouling polymer brushes.

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“…According to these results, Mirshafiee et al clarified that NPs incubated in human plasma bind larger amounts of proteins and may trigger more adverse immune response than those exposed to human serum. We now know that the protein corona is also shaped by several environmental factors such as protein concentration (Caracciolo et al, ; Monopoli et al, ), temperature (Mahmoudi, Abdelmonem, et al, ; Mahmoudi, Lohse, et al, ), local heating (Mahmoudi, Abdelmonem, et al, ; Mahmoudi, Lohse, et al, ), incubation time (Barrán‐Berdón et al, ; Tenzer et al, ), and shear stress (Digiacomo et al, ; Palchetti et al, ; Pozzi, Caracciolo, Capriotti, et al, ; Pozzi, Caracciolo, Digiacomo, et al, ; Yu, Andruschak, Yeh, Grecov, & Kizhakkedathu, ).…”

Section: Nanomaterials In Physiological Environments: Challenges and mentioning

confidence: 99%

Impact of the protein corona on nanomaterial immune response and targeting ability

Digiacomo

Pozzi

Palchetti

et al. 2020

WIREs Nanomed Nanobiotechnol

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Over the last decade nanomaterials have had a major impact on human health for the early detection and treatment of many diseases. The future success of clinically translatable nanomaterials lies in the combination of several functionalities to realize a personalized medical experience for patients. To maintain promises, concerns arising from toxic potential and off‐target accumulation of nanomaterials must be addressed first. Upon introduction to a complex biological system (e.g., following systemic administration), nanomaterials interact with all the encountered biomolecules and form the protein corona, a complex coating of plasma proteins that provides them with a totally new biological identity. As the protein corona controls the nanomaterial behavior in vivo, a precise knowledge of the relationship between biological identity and physiological response is needed but not yet achieved. Based on impressive progress made thus far, this review critically discusses how the protein corona activates immune response and influences the targeted delivery of nanomaterials. Furthermore, we comment on emerging strategies to manipulate protein binding in order to promote formation of designer artificial coronas and achieve a desired therapeutic outcome. We conclude by debating challenges that must be overcome to obtain widespread clinical adoption of nanomaterials. This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes

Cited by 39 publications

References 73 publications

Self‐Limiting Mussel Inspired Thin Antifouling Coating with Broad‐Spectrum Resistance to Biofilm Formation to Prevent Catheter‐Associated Infection in Mouse and Porcine Models

Self‐Limiting Mussel Inspired Thin Antifouling Coating with Broad‐Spectrum Resistance to Biofilm Formation to Prevent Catheter‐Associated Infection in Mouse and Porcine Models

Atomistic Study of Zwitterionic Peptoid Antifouling Brushes

Impact of the protein corona on nanomaterial immune response and targeting ability

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