Influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with Helicobacter pylori

Araújo, José Carlos Ribeiro de; Carvalho, Jorge José de; Serra, Humberto Oliveira

doi:10.1590/0100-69912016004003

Cited by 5 publications

(3 citation statements)

References 22 publications

(15 reference statements)

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“…This might have occurred because of the possible triggering of inflammatory conditions. It is believed that after the gastrectomy, the region of the anastomosis starts to show chronic proinflammatory characteristics due to the presence of foreign bodies (sutures) and the continuous contact with the duodenogastric contents [ 91 ]. It is known, therefore, that hepcidin production is stimulated in vivo and in vitro by LPS or turpentine, standard inflammatory stimuli.…”

Section: Discussionmentioning

confidence: 99%

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

et al. 2018

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Polydextrose (PDX) ingestion may increase the intestinal absorption of iron. This study evaluated the effects of 7.5% polydextrose supplementation on markers of iron uptake, transport and storage in partially gastrectomized rats. Half of a batch of 40 male Wistar rats (250 g) underwent Billroth II partial gastrectomy with anterior truncal vagotomy (GXT), while the other half underwent sham gastrectomy (SHAM). At 7 postoperative days, the animals were subdivided into four groups (n = 10): Sham Control and GXT Control (no polydextrose); Sham PDX and GXT PDX (with 7.5% PDX). The animals were euthanized after 60 day of PDX treatment. Organ weight, cecal pH, the characterization and quantification of short-chain fatty acids (SCFA), hematological parameters, hepatic iron content and the expression of ferroportin (FPT) in the jejunum, cecum, colon and liver were evaluated. PDX caused changes in the cecum of the supplemented animals, where there was a decrease in pH, increase in cecal wall and marked production of SCFA, especially acetic and propionic acids (p < 0.05). Hepatic iron levels were lower in GXT animals. PDX increased hemoglobin (HGB) values by 29.2% and hematocrit (HCT) by 55.8% in the GXT PDX group compared to the GXT Control group. The GXT PDX group had lower hepatic FPT expression (p < 0.05). PDX led to increased SCFA concentration in the supplemented animals. Considering that SCFAs play a central role in the increasing nutrients uptake, this mechanism may be involved in altering the hematology profile observed in these animals but not enough to reverse iron deficiency anemia in post-gastrectomy rats.

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Section: Discussionmentioning

confidence: 99%

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

et al. 2018

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“…At the end of the study hearts from all groups were isolated through a midline thoracotomy under pentobarbital (150mg/kg i.p.) anesthesia [13] . Hearts were rapidly excised and immediately placed in ice cold Kreb-Henseleit heparinized solution.…”

Section: Ex-vivo Cardiac Contractility Assessmentmentioning

confidence: 99%

Resveratrol Improves Cardiac Functions of the Diabetic Cardiomyopathy Rats Via Modulation of AMP-Activated Protein Kinase and the Phosphorylated Glycogen Synthase Kinase-3(3

Shamseldeen¹,

Rashed²,

Elsayed³

et al. 2019

The Medical Journal of Cairo University

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Background: Resveratrol (RSV) has a wide range of diabetic cardioprotective effects. It is currently recognized as a dietary supplement. Aim of Study:To investigate the impact of RSV on the molecular expression pattern of AMP-activated protein kinase (AMPK) and the glycogen synthase kinase-3 (3 serine 9 (GSK-3 (3 S9) in diabetic cardiomyopathy. Methods:We investigated this point using three groups of Wistar albino rats; control group, diabetic cardiomyopathy rats (DCM) and diabetics treated with RSV (DM-RSV) for 20 weeks. Echocardiography was performed at base line, and every 4 weeks. At the end of the study, Ex-vivo assessment of myocardial contractility was performed. The molecular changes in the cardiac tissues were evaluated in all groups for assessment of the silent information regulator (SIRT1), GSK-3 (3 S9 and the AMPK levels. Histological assessment was done for all cardiac tissues. Apoptosis was assessed by measuring the modulation in the Bax/Bcl2 ratio and poly (ADP-ribose) polymerase-1 (PARP1) levels, trying to explore the RSV underlying mechanism of action.Results: Marked deterioration in the cardiac functions was detected in the diabetic non treated group. The decreased levels of SIRT1, AMPK and GSK-3 (3 S9 that was associated with increased apoptotic markers, may be the cause of deteriorated cardiac functions. Assessment of the myocardial functions showed improvement in the diabetic RSV treated group. RSV aimed to normalize the hyperglycemic state and the disturbed molecular pattern associated with diabetes.Conclusion: Prolonged RSV administration protects the diabetic hearts. This could be explained by the interplay between SIRT1, AMPK and the GSK-3(3 S9 levels.

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“…Furthermore, clinical and experimental studies have been carried out to investigate whether surgical techniques that promote duodenogastric reflux may be involved in the development of gastric cancer 11,12 . The intensity of glandular atrophy and intestinal metaplasia is directly related to the reflux of duodenal secretions to the gastric mucosa 13,14 .…”

Section: ■ Introductionmentioning

confidence: 99%

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?

Monteiro¹,

Rodrigues

Araújo

et al. 2020

Acta Cir. Bras.

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Influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with Helicobacter pylori

Cited by 5 publications

References 22 publications

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats

Resveratrol Improves Cardiac Functions of the Diabetic Cardiomyopathy Rats Via Modulation of AMP-Activated Protein Kinase and the Phosphorylated Glycogen Synthase Kinase-3(3

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect?

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