Influence of drying processes on the structures, morphology and <i>in vitro</i> release profiles of risperidone-loaded PLGA microspheres

Wu, Zhaoying; Zhao, Mengqing; Zhang, Wei; Zhao, Yang; Xu, Shuxin; Shang, Qianqian

doi:10.1080/02652048.2019.1582723

Cited by 13 publications

(5 citation statements)

References 42 publications

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“…The drying process has also been shown to affect PLGA microsphere properties (Deshmukh et al, 2016;Wu et al, 2019). After solidification, PVA and other non-volatile organic solvents must be removed from the microspheres.…”

Section: The Drying Phasementioning

confidence: 99%

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Hua¹,

Su²,

Zhang³

et al. 2021

Drug Delivery

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Poly(lactic-co-glycolic acid) (PLGA) has garnered increasing attention as a candidate drug delivery polymer owing to its favorable properties, including its excellent biocompatibility, biodegradability, nontoxicity, non-immunogenicity, and mechanical strength. PLAG are specifically used as microspheres for the sustained/controlled and targeted delivery of hydrophilic or hydrophobic drugs, as well as biological therapeutic macromolecules, including peptide and protein drugs. PLGAs with different molecular weights, lactic acid (LA)/glycolic acid (GA) ratios, and end groups exhibit unique release characteristics, which is beneficial for obtaining diverse therapeutic effects. This review aims to analyze the composition of PLGA microspheres, and understand the manufacturing process involved in their production, from a quality by design perspective. Additionally, the key factors affecting PLGA microsphere development are explored as well as the principles involved in the synthesis and degradation of PLGA and its interaction with active drugs. Further, the effects elicited by microcosmic conditions on PLGA macroscopic properties, are analyzed. These conditions include variations in the organic phase (organic solvent, PLGA, and drug concentration), continuous phase (emulsifying ability), emulsifying stage (organic phase and continuous phase interaction, homogenization parameters), and solidification process (relationship between solvent volatilization rate and curing conditions). The challenges in achieving consistency between batches during manufacturing are addressed, and continuous production is discussed as a potential solution. Finally, potential critical quality attributes are introduced, which may facilitate the optimization of process parameters.

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Section: The Drying Phasementioning

confidence: 99%

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Hua¹,

Su²,

Zhang³

et al. 2021

Drug Delivery

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show abstract

“…Nanomaterials can be effectively modified in morphology and size through ultrasonic treatment. MOF particle size and morphology affect the delivery of drugs in complex biological media by influencing the biodistribution of carriers, releasing drugs, cellular internalization, and drug clearance as well as physicochemical features (adsorption, diffusion and material stability). − …”

Section: Resultsmentioning

confidence: 99%

Computational Simulation of a Three-Dimensional Mg-based Metal–Organic Framework as Nanoporous Anticancer Drug Carrier

Parsaei,

Akhbari,

Tylianakis

et al. 2023

Crystal Growth & Design

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In this research, a 3D Mg-based metal−organic f r a m e w o r k ( M U T -8 ) w i t h t h e f o r m u l a [Mg 5 (DBrTPA) 4 (DMF) 6 (HCOO) 2 ] [DBrTPA = 2,5-dibromoterephthalic acid] was prepared through a solvothermal reaction with and without ultrasonic radiation. Single-crystal X-ray crystallography was used to solve the crystal structure, and several techniques were employed to characterize the structure thoroughly. Moreover, an investigation was carried out to evaluate the solvent stability of MUT-8 across a range of organic solvents. Furthermore, computational simulations were employed to assess the drug-loading capabilities and the capacity of MUT-8. Based on Grand Canonical Monte Carlo simulations (GCMC), MUT-8 was determined to be an effective nanoporous drug carrier for the Quercetin anticancer drug, exhibiting significant uptake even at extremely low fugacity levels and achieving a saturation loading of 300 mg/mg.

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“…The size and morphology of MOF particles have been controlled using different strategies, including change in solvent, modulator, temperature, reaction time, pH, metal to ligand ratio, microwave-assisted, and sonochemical synthetic techniques. Controlled modifications of the morphology and size of MOFs have been achieved through various methods in a wide range of applications including semiconductors, catalysts, gas storage, and separation. − The size and morphology of MOF particles influence physicochemical properties (material stability and adsorption and diffusion processes) and play a vital role in drug delivery by affecting the carrier biodistribution, drug release kinetics, cell internalization, and the clearance of the drug in complex biological media. − …”

Section: Resultsmentioning

confidence: 99%

Computational Study of Two Three-Dimensional Co(II)-Based Metal–Organic Frameworks as Quercetin Anticancer Drug Carriers

Parsaei

Akhbari

Tylianakis

et al. 2022

Crystal Growth & Design

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Two three-dimentional Co-based metal–organic frameworks with the formulae of [Co3(2-BrTPA)3].(DMF)4 (MUT-6) and [Co5(DBrTPA)4(DMF)6(HCOO)2] (MUT-7) [2-BrTPA = 2-bromoterephthalic acid, DBrTPA = 2,5-dibromoterephthalic acid] were synthesized through various synthetic techniques. The structures were fully characterized using a series of techniques, and the crystal structures were solved using single-crystal X-ray crystallography. Furthermore, the solvent stability test was conducted in various organic solvents. Using grand canonical Monte Carlo simulations, MUT-7 was proven to be a good candidate as a drug carrier for the quercetin anticancer drug because it shows remarkable uptake starting to adsorb at very low fugacity values and reaching a saturation loading as high as 200 mg/g.

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Influence of drying processes on the structures, morphology and in vitro release profiles of risperidone-loaded PLGA microspheres

Cited by 13 publications

References 42 publications

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Computational Simulation of a Three-Dimensional Mg-based Metal–Organic Framework as Nanoporous Anticancer Drug Carrier

Computational Study of Two Three-Dimensional Co(II)-Based Metal–Organic Frameworks as Quercetin Anticancer Drug Carriers

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