Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study

Arbeiter, Daniela; Reske, Thomas; Teske, Michael; Bajer, D.; Senz, Volkmar; Schmitz, Klaus‐Peter; Grabow, Niels; Oschatz, Stefan

doi:10.3390/polym13020292

Cited by 17 publications

(11 citation statements)

References 74 publications

(74 reference statements)

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“…The tensile strain value also decreased with 30 mg of J addition (20.67 ± 4.90%), however, it still had a higher value compared to the PLA ( w / v ) strain value. These results are in agreement with the literature data [ 24 , 25 ]. It can be concluded that the J addition induced an increase in the tensile strength, making the scaffold more elastic.…”

Section: Resultssupporting

confidence: 94%

Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material

et al. 2022

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Juglone (5-hydroxy-1,4-naphthoquinone) (J) is a naphthoquinone structured allelochemical that is mostly found in the roots, leaves, nut-hulls, bark, and wood of walnut (Juglans regia). In this study, the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the poly(lactic acid) (PLA) (w/v)/J (10, 20, 30 mg) electrospun scaffolds were investigated. Based on the results of the study, it was shown that juglone addition increased the antimicrobial properties of the scaffolds against the Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), compared to the neat PLA film after 24 h of contact time. According to the tensile test results, the addition of J made the scaffolds more flexible but decreased the mechanical strength. The cytotoxicity properties of the J-added scaffolds demonstrated a toxic behavior on the first day of incubation. However, with an increase in the J ratio, the fibroblast cell metabolic activity increased for all incubation periods.

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Section: Resultssupporting

confidence: 94%

Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material

et al. 2022

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“…The T g values are similar in bulk and empty particles but increase with drug loading due to the incorporation of dexamethasone that has a high T g (117 °C). The observed increase in T g of the drug-loaded particles was expected with incorporating a high T g drug . A single T g value was observed during the second heat, indicating polymer–drug miscibility for all formulations prepared after temperature processing.…”

Section: Resultsmentioning

confidence: 69%

Control of Drug Release from Microparticles by Tuning Their Crystalline Textures: A Structure–Activity Study

Miles

Bernstein

Popp

et al. 2021

ACS Appl. Polym. Mater.

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Predicting drug release profiles from polymer microparticles has proven challenging due to the numerous environmental and chemical factors that affect the device and influence the rate of drug release. By measuring the various polymer properties that can influence drug release, a predictive approach can be used to select polymers with specific properties that will lead to the desired release profile for the application. To illustrate this, a library of tyrosol-derived poly(ester-arylate)s, poly(amide)s, and poly(carbonate)s were used to evaluate the effects of physical (crystallinity, water accessibility, thermal, and hydrophobicity) and chemical (polymer−drug interactions) polymer properties on the release of a highly crystalline drug dexamethasone, which was loaded at a high weight percent (wt %) in microparticles. Nuclear magnetic resonance (NMR) experiments showed that the polymer and drug were not chemically interacting and instead exist as a physical mixture even after exposure to physiological conditions. Polymer crystallinity data revealed that crystallite size was strongly correlated with faster drug release, suggesting that larger crystallites reduce the tortuosity for dexamethasone to diffuse out of the particle matrix. This correlation observed in particles with and without the drug was reproduced with bulk polymers, indicating that crystallinity data from bulk polymers can be used to predict release profiles without having to prepare drug-loaded particles. Consistent with the crystallinity data, particle pore sizes of representative formulations showed that particles with larger pores resulted in faster dexamethasone release. Interestingly, thermal properties (glass transition temperature and melting temperature), polymer hydrophobicity, and molecular weight retention at the end of the 119-day release study did not show any correlation with drug release.

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“…The used micro-stent coating material PLLA is a well-known and established coating material for cardiovascular devices and controlled drug release systems [11] including direct mixing or adsorption of antibiotics or drug encapsulation in microspheres or coreshell porous nanofibers to avoid burst-release. [12][13][14] Therefore, this material is an ideal candidate for the validation of our in vivo model for testing antimicrobial materials in the bloodstream for cardiovascular devices.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Murine Model for Testing Antimicrobial Implant Materials in the Blood Circulation System

et al. 2021

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Medical device-related infections are becoming a steadily increasing challenge for the health care system regarding the difficulties in the clinical treatment. In particular, cardiovascular implant infections, catheter-related infections, as well as infective endocarditis are associated with high morbidity and mortality risks for the patients. Antimicrobial materials may help to prevent medical device-associated infections and supplement the currently available therapies. In this study, we present an easy-to-handle and simplified in vivo model to test antimicrobial materials in the bloodstream of mice. The model system is composed of the implantation of a bacteria-laden micro-stent scaffold into the murine tail vein. Our model enables the simulation of catheter-related infections as well as the development of infective endocarditis specific pathologies in combination with material testing. Furthermore, this in vivo model can cover two phases of the biofilm formation, including both the local tissue response to the bacterial biofilm and the systemic inflammatory response against circulating bacteria in the bloodstream that detached from a mature biofilm.

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Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study

Cited by 17 publications

References 74 publications

Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material

Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material

Control of Drug Release from Microparticles by Tuning Their Crystalline Textures: A Structure–Activity Study

Evaluation of a Murine Model for Testing Antimicrobial Implant Materials in the Blood Circulation System

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