Influence of Dopamine and Noradrenaline on Isolated Cerebral Arteries of the Dog

Toda, Noboru

doi:10.1111/j.1476-5381.1976.tb07700.x

Cited by 77 publications

(26 citation statements)

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“…Dopaminergic agonists (such as apomor phine) interact with specific dopaminergic receptors that have been identified on cerebrovascular smooth muscle in vitro and in situ (Toda, 1976;Ed vinsson et ai., 197&l,b), and this direct action upon the cerebral vasculature has been proposed to ac count for the changes in CBF that have been re ported following the administration of dopamine and apomorphine (von Essen, 1974;von Essen and Roos, 1974). However, the administration of dopaminergic agonists (such as amphetamine, apomorphine, and piribedil) results in an increase in cerebral oxygen consumption, and the concomitant increases in CBF that are observed with these agents have been suggested to be a consequence of the increased metabolic demand (McCulloch and Harper, 1977a,b;McCulloch and Edvinsson, 1980).…”

mentioning

confidence: 99%

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

McCulloch

Kelly

Ford

1982

J Cereb Blood Flow Metab

124

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Summary:The alterations in local glucose utilization and local blood flow in 36 discrete regions of the central nervous system (CNS) that occur following the intravenous administration of the putative dopaminergic agonist, apomor phine (0,5 mg/kg), have been measured using the quantitative autoradiographic 14C-2-deoxyglucose and 14C-iodoantipyrine techniques, In eight of the regions examined (frontal and sensory-motor cortices, ventral thalamus, caudate nu cleus, globus pallidus, substantia nigra, subthalamic nucleus, and posterior cerebellar hemisphere), significant elevations of local cerebral blood flow (CBF) were observed following apomorphine administration. In these eight regions, proportionately similar, significant elevations in local glucose utiliza tion were observed following apomorphine. In two of the regions investigated (anterior cingulate cortex and lateral habenular nucleus), significant reductions in both local blood flow and glucose utilization were observed following apomorphine administration. In the majority of regions examined (26 of the total 36), apomorphine did not alter significantly either blood flow or glucose use. Using a statistical approach, described in detail in an appendix, the re lationship between local rates of glucose utilization and local levels of tissue blood flow was analyzed. A relationship between local CBF and local glucose utilization was found following apomorphine, and the nature of this relation ship was indistinguishable from that observed in control animals. In no region of the CNS was a significant deviation from the normal CBF -glucose use relationship demonstrated following apomorphine administration. These re sults point to the greater importance of the effects of apomorphine upon tissue metabolic activity, rather than its direct vascular action, as being the major mechanism underlying the observed alterations in local CBF. The statistical methods provide a rigorous analytical approach to the analysis of alterations in the relationship, both locally and globally, of blood supply to glucose utiliza tion.

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confidence: 99%

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

McCulloch

Kelly

Ford

1982

J Cereb Blood Flow Metab

124

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“…6). (11)(12)(13)(14)(15)(16). Hence, it is not likely that nigral-induced decrease in striatal blood flow in the present experiment is due to a direct effect of dopamine because phentolamine did not affect this decrease.…”

Section: Methodsmentioning

confidence: 63%

Nigral-Induced Decrease in Striatal Blood Flow and the Influence on This Decrease of Several Drugs in Reserpinized and Non-Reserpinized Cats

Yanagihashi

1986

Japanese Journal of Pharmacology

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Abstract-The effect of nigral electrical stimulation on regional blood flow in the caudate nucleus and the cerebral cortex, and the influence of several drugs on these effects were examined in reserpinized or non-reserpinized cats. A double thermistor element was inserted into the left caudate nucleus, and a plate-type thermocouple element was put on the left cerebral cortex. The left substantia nigra was electrically stimulated for 10 sec through a concentric bipolar electrode with a diameter of 0.3 mm (30 Hz, 1 msec, 10-30 V). In non-reserpinized cats, the nigral stimulation caused a decrease in striatal blood flow, increase in cortical blood flow and rise in mean blood pressure. Hexamethonium (3 mg/kg, i.v.) blocked completely the rise in mean blood pressure following nigral stimulation, but did not affect a decrease in striatal blood flow, indicating that a decrease in striatal blood flow following nigral stimulation was not due to the activation of the peripheral sympathetic nervous system. Nigral-induced decrease in striatal blood flow in non-reserpinized cats was blocked by haloperidol (0.1 mg/kg, i.v.), methysergide (1 mg/kg, i.v.) and reserpine (2 mg/kg, i.v.), but not by phentolamine (7 mg/kg, i.v.). In reserpinized cats, nigral stimulation caused an increase in striatal blood flow in contrast to a decrease in non-reserpinized cats. After administration of 5-HTP (50 mg/kg, i.v.) in reserpinized cats, nigral stimulation decreased the striatal blood flow. On the other hand, after administration of L-DOPA (30 mg/kg, i.v.) in reserpinized cats, nigral stimulation increased striatal blood flow. These results suggest that a decrease in striatal blood flow following nigral stimulation is due to the activation of a serotonergic mechanism mediated by dopaminergic neurons.

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“…It is concluded that electrical and chenmical (nicotine-induced) stimulation liberates unknown vasodilator substance(s) possibly from the same site in the arterial wall. Since adenosine 5'-triphosphate (ATP) produces a transient contraction followed by a sustained relaxation (Hayashi, Okunishi, Konishi & Toda, 1979) and the relaxation is suppressed by treatment with aminophylline in cerebral arteries (Toda, 1976b), it seems unlikely that the cerebro-arterial relaxation is mediated by ATP. These results are in agreement with the findings by Lee, Hume, Su & Bevan (1978).…”

Section: Discussionmentioning

confidence: 99%

Non‐adrenergic, Non‐cholinergic Innervation in Monkey and Human Cerebral Arteries

Toda

1981

British J Pharmacology

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1Transmural electrical stimulation (0.5 to 20 Hz) and nicotine (10' M) produced relaxations of helically-cut strips of monkey and human cerebral arteries, contracted with prostaglandin F22. 2 The relaxation induced by electrical stimulation was suppressed or abolished by tetrodotoxin, while the nicotine-induced relaxation was abolished by hexamethonium but was unaffected by tetrodotoxin. Both relaxations were not attenuated by ,B-adrenoceptor antagonists and atropine. 3 These findings may indicate that large cerebral arteries of the monkey and man are innervated by non-adrenergic, non-cholinergic nerves, excitation of which liberates unknown vasodilator substance(s).

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Influence of Dopamine and Noradrenaline on Isolated Cerebral Arteries of the Dog

Cited by 77 publications

References 10 publications

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

Effect of Apomorphine on the Relationship between Local Cerebral Glucose Utilization and Local Cerebral Blood Flow (with an Appendix on its Statistical Analysis)

Nigral-Induced Decrease in Striatal Blood Flow and the Influence on This Decrease of Several Drugs in Reserpinized and Non-Reserpinized Cats

Non‐adrenergic, Non‐cholinergic Innervation in Monkey and Human Cerebral Arteries

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