Influence of Donor and Recipient Sex Matching in Simultaneous Pancreas-Kidney Transplantation Outcomes

Influence of donor and recipient sex on outcomes following simultaneous pancreas–kidney transplantation in the new millennium: Single‐center experience and review of the literature

“…Their results indicated that sex matching did not have any significant impact on perioperative outcomes as well as patient and GSRs at 5, 10, and 15‐year follow‐up compared to unmatched donor‐recipient pairs. In contrast to the SRTR study by Li, both Sanchez Hidalgo and Messner recommended that factors other than sex matching between donor and recipients of SPKTs be employed to optimize outcomes since transplanting sex‐mismatched organs is a safe practice 18 . This strategy is particularly true in light of superior outcomes in the new millennium because of improvements in donor and recipient selection and management, advances in preservation and immunosuppression, refinements in surgical techniques, and better posttransplant management and monitoring 1–5 …”

“…In addition, there is an unequal distribution of donor and recipient sex in SPKT. In most studies, 65%–70% of donors and 55%–60% of recipients are male 10–12,14–18 . Consequently, the donor male/recipient male category represents about 40% of cases whereas the donor female/recipient female category accounts for only about 13% of cases.…”

“…In 2021, Sánchez Hidalgo et al. performed a single center retrospective review of 199 patients who underwent SPKT from February 1989 to June 2019 at the Reina Sofia University Hospital in Spain 18 . The study focused on the impact of donor‐recipient sex matching on patient, pancreas, and kidney survival outcomes.…”

“…The potential benefits of donor‐recipient sex matching compared to mismatching have been attributed to a number of factors that include (1) Technical – avoiding mismatches in graft size, functional mass, or vessel diameter; (2) Hormonal – avoiding variable effects of estrogen and testosterone levels on ischemia‐reperfusion injury; (3) Immunologic – eliminating the potential role of the H‐Y antigen, differences in sex steroid secretion, and drug metabolism; and (4) Behavioral – minimizing differences in smoking and medication compliance. The importance of donor and recipient sex on outcomes following SPKT remains uncertain with only a few recent reports in the literature to date 10–18 . The purpose of this study was to analyze retrospectively our single‐center experience in 255 SPKT recipients in the modern era (new millennium) to determine the effects, if any, that donor and recipient sex have on short and long‐term outcomes.…”

“…The importance of donor and recipient sex on outcomes following SPKT remains uncertain with only a few recent reports in the literature to date. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 The purpose of this study was to analyze retrospectively our single‐center experience in 255 SPKT recipients in the modern era (new millennium) to determine the effects, if any, that donor and recipient sex have on short and long‐term outcomes.…”