Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

Deepika, R.; Girigoswami, Koyeli; Murugesan, Ramachandran; Girigoswami, Agnishwar

doi:10.2174/1567201814666170825160617

Cited by 30 publications

(8 citation statements)

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“…In the case of NaCl, a comparatively diffuse distribution is seen, with ions acting primarily to screen the charge. This behavior of weak polyelectrolytes depicted here in the presence of divalent salt could be particularly useful for adhesion of polymers in hydrogels and can offer more tuning opportunities for targeted drug delivery [96,98,99,100,101,102].…”

Section: Resultsmentioning

confidence: 99%

Explicit Ion Effects on the Charge and Conformation of Weak Polyelectrolytes

et al. 2019

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The titration behavior of weak polyelectrolytes is of high importance, due to their uses in new technologies including nanofiltration and drug delivery applications. A comprehensive picture of polyelectrolyte titration under relevant conditions is currently lacking, due to the complexity of systems involved in the process. One must contend with the inherent structural and solvation properties of the polymer, the presence of counterions, and local chemical equilibria enforced by background salt concentration and solution acidity. Moreover, for these cases, the systems of interest have locally high concentrations of monomers, induced by polymer connectivity or confinement, and thus deviate from ideal titration behavior. This work furthers knowledge in this limit utilizing hybrid Monte Carlo–Molecular Dynamics simulations to investigate the influence of salt concentration, pK a , pH, and counterion valence in determining the coil-to-globule transition of poorly solvated weak polyelectrolytes. We characterize this transition at a range of experimentally relevant salt concentrations and explicitly examine the role multivalent salts play in determining polyelectrolyte ionization behavior and conformations. These simulations serve as an essential starting point in understanding the complexation between weak polyelectrolytes and ion rejection of self-assembled copolymer membranes.

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Section: Resultsmentioning

confidence: 99%

Explicit Ion Effects on the Charge and Conformation of Weak Polyelectrolytes

et al. 2019

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“…A study by Deepika et al [ 44 ] was about the formation of levofloxacin in chitosan-alginate hybrid gel for controlled release and effect of divalent alkaline ions (Mg 2+ , Ca 2+ , Sr 2+ , and Ba 2+ ) on encapsulation efficiency and drug release kinetics from chitosan-alginate nanostructure was investigated. The particle size increases and encapsulation efficiency decreases with the size of the divalent ions.…”

Section: Introductionmentioning

confidence: 99%

Current Status of Alginate in Drug Delivery

Hariyadi

Islam

2020

Advances in Pharmacological and Pharmaceutical Sciences

131

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Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.

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“…Release medium can also have a significant impact on the rate of therapeutic release. A study by Deepika et al 35 investigated the impacts of divalent ions including Mg 2+ and Ca 2+ on release of anionic levofloxacin from a chitosan‐alginate hybrid gel nanoparticles. Metal ions were shown to have a significant influence on nanoparticle morphology, drug encapsulation efficiency, and release profile from these nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Tunable alginate hydrogels as injectable drug delivery vehicles for optic neuropathy

Maxwell

Soltisz

Rich

et al. 2022

J Biomedical Materials Res

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Many disease pathologies, particularly in the eye, are induced by oxidative stress. In particular, injury to the optic nerve (ON), or optic neuropathy, is one of the most common causes of vision loss. Traumatic optic neuropathy (TON) occurs when the ON is damaged following blunt or penetrating trauma to either the head or eye. Currently, there is no effective treatment for TON, only management options, namely the systematic delivery of corticosteroids and surgical decompression of the optic nerve. Unfortunately, neither option alleviates the generation of reactive oxygen species (ROS) which are responsible for downstream damage to the ON. Additionally, the systemic delivery of corticosteroids can cause fatal off‐target effects in cases with brain involvement. In this study, we developed a tunable injectable hydrogel delivery system for local methylene blue (MB) delivery using an internal method of crosslinking. MB was chosen due to its ROS scavenging ability and neuroprotective properties. Our MB‐loaded polymeric scaffold demonstrated prolonged release of MB as well as in situ gel formation. Additionally, following rheological characterization, these alginate hydrogels demonstrated minimal cytotoxicity to human retinal pigment epithelial cells in vitro and exhibited injection feasibility through small‐gauge needles. Our chosen MB concentrations displayed a high degree of ROS scavenging following release from the alginate hydrogels, suggesting this approach may be successful in reducing ROS levels following ON injury, or could be applied to other ocular injuries.

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Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

Abstract: Therefore, it is concluded that metal ions have significant influence on the morphology and drug encapsulation and release profile of the chitosan-alginate hybrid polymer nanoparticles.

Cited by 30 publications

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Explicit Ion Effects on the Charge and Conformation of Weak Polyelectrolytes

Explicit Ion Effects on the Charge and Conformation of Weak Polyelectrolytes

Current Status of Alginate in Drug Delivery

Tunable alginate hydrogels as injectable drug delivery vehicles for optic neuropathy

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